CBSET Publications
2024
BJUI: Relationship between renal pelvis pressure and post-ureteroscopy infection in a live swine model
Regenerative Medicine: Evaluation of bi-layer silk fibroin grafts for onlay urethroplasty in a rabbit model of urethral stricture disease
Journal of Pharmacological and Toxicological Methods: Maximizing insights from nonclinical safety studies in the context of rising costs and changing regulations
Advanced Materials: Sprayable Hydrogel Sealant for Gastrointestinal Wound Shielding
BJU International: A novel technique for measurement of fluid absorption during ureteroscopy
Frontiers in Molecular Neuroscience: Ototoxicity: a high risk to auditory function that needs to be monitored in drug development
ASAIO Journal: Steady Flow Left Ventricle Unloading Is Superior to Pulsatile Pressure Augmentation Venting During Venoarterial Extracorporeal Membrane Oxygenation Support
Science Translational Medicine: Dynamic load modulation predicts right heart tolerance of left ventricular cardiovascular assist in a porcine model of cardiogenic shock
American Journal of Physiology: Decreased LPS-induced lung injury in pigs treated with a lung surfactant protein A-derived nonapeptide that inhibits peroxiredoxin 6 activity
2023
Bioengineering: Cardiovascular Tissue Engineering Models for Atherosclerosis Treatment Development
Annals of Biomedical Engineering: Investigating Balloon-Vessel Contact Pressure Patterns in Angioplasty: In Silico Insights for Drug-Coated Balloons
EuroIntervention: Histological examination of renal nerve distribution, density, and function in humans
2022
Journal of Immunology and Regenerative Medicine: Early tissue growth and cell fate determination following segmental esophageal repair using a tissue engineered esophageal implant composed of a polyurethane scaffold seeded with autologous adipose-derived mesenchymal stromal cells
Frontiers in Gastroenterology: Comparison of PuraStat self-assembling peptide hydrogel versus mineral-based Hemospray for endoscopic hemostasis of upper and lower gastrointestinal lesions in pigs
BJU International: Evaluation of fluid absorption during flexible ureteroscopy in an in vivo porcine model
Scientific Reports: Morphometric analysis of the human common hepatic artery (CHA) reveals a rich and accessible target for sympathetic liver denervation
2021
Annual International Conference of the IEEE Engineering in Medicine & Biology Society: An in silico trials platform for the evaluation of effect of the arterial anatomy configuration on stent implantation
Annals of Otology, Rhinology & Laryngology: Safety and Feasibility of a Novel Esophageal Balloon for Circumferential Cytologic Sampling
Clinical Research in Cardiology: Combined renal and common hepatic artery denervation as a novel approach to reduce cardiometabolic risk: technical approach, feasibility and safety in a pre-clinical model
2020
JB & JS: Activation of Bone Remodeling Compartments in BMP-2-Injected Knees Supports a Local Vascular Mechanism for Arthritis-Related Bone Changes
Biomaterials: Balloon-based drug coating delivery to the artery wall is dictated by coating micro-morphology and angioplasty pressure gradients
HEAR THIS! Potential Therapeutics for COVID-19 Should Be Tested for Auditory Safety
Annu Int Conf IEEE Eng Med Biol Soc: Design and implementation of in silico clinical trial for Bioresorbable Vascular Scaffolds
Circulation: Arrhythmia and Electrophysiology: Pulsed Field Ablation Using a Lattice Electrode for Focal Energy Delivery: Biophysical Characterization, Lesion Durability, and Safety Evaluation
Circulation: Mortality and Paclitaxel-Coated Devices: An Individual Patient Data Meta-Analysis
Biomedical Instrumentation & Technology: Analysis: Intravascular Devices with a Higher Risk of Polymer Emboli: The Need for Particulate Generation Testing
Journal of Neuerointerventional Surgery: Preclinical evaluation of the ANCD thrombectomy device: safety and efficacy in a swine clot model
2019
Athrosc Sports Med Rehabil: Suture-Based Debris Behavior in the Draining Lymph Nodes of a Porcine Knee
Journal of Controlled Release: Taking paclitaxel coated balloons to a higher level: Predicting coating dissolution kinetics, tissue retention and dosing dynamics
Lymphat Res Biol: Development of a Porcine Lymph Drainage Model to Study Particle Migration
Translational Research: Splenic artery denervation: target micro-anatomy, feasibility, and early preclinical experience
Hypertension: Procedural and Anatomical Determinants of Multielectrode Renal Denervation Efficacy
EuroIntervention: Pulmonary Artery Denervation Using Catheter based Ultrasonic Energy.
Toxicologic Pathology: Preclinical Evaluation of Mesh Implants: The Pathologist’s Perspective
Toxicologic Pathology: An Overview on the Considerations for the Planning of Nonclinical Necropsies for Medical Device Studies
Not a Single Drug Is Approved to Treat Hearing Loss, but Now There Is Hope
Catheterization and Cardiovascular Interventions: Fracture in drug-eluting stents increases focal intimal hyperplasia in the atherosclerosed rabbit iliac artery
2018
International Journal of Toxicology: Percutaneous Hepatic Perfusion With Filtered Melphalan for Localized Treatment of Metastatic Hepatic Disease: A Risk Assessment
Biomaterials Forum: Stem cell therapies for peripheral arterial disease: clinical status, promising biomaterials strategies and tips for successful translation
Cardiovascular Revascularization Medicine: Anatomical and procedural determinants of ambulatory blood pressure lowering following catheter-based renal denervation using radiofrequency
Eurointervention: Renal artery anatomy assessed by quantitative analysis of selective renal artery in 1000 patients with hypertension
The International Journal of Cardiology Imaging: Vessel centerline reconstruction from non-isocentric and non-orthogonal paired monoplane angiographic images
Respirology: Pharmacokinetics and safety of paclitaxel delivery into porcine airway walls by a new endobronchial drug delivery catheter
Expert Opinion in Drug Delivery: Intracochlear Drug Delivery Systems: A Novel Approach Whose Time Has Come
World Pharma Today: Stem Cell and Regenerative Therapies for Hearing Loss
Journal of Controlled Release: Defining drug and target protein distributions after stent-based drug release: Durable versus deployable coatings
PLoS One: Sex differences in the outcomes of stent implantation in mini-swine model
2017
EuroIntervention: Lost in translational filters between peers
World Pharma Today: Auditory Therapy, Ototoxicity, and GLP Compliance: Will the promising market for ear disorder treatments follow ophthalmology’s dramatic growth curve?
Circulation: Randomized Comparison of Ridaforolimus- and Zotarolimus-Eluting Coronary Stents in Patients With Coronary Artery Disease: Primary Results From the BIONICS Trial
Journal of Controlled Release: Calcified plaque modification alters local drug delivery in the treatment of peripheral atherosclerosis
Journal of Orthopaedic Research: Biocompatibility, bone healing, and safety evaluation in rabbits with an IlluminOss bone stabilization system
JAVMA: Cystoscopic diagnosis of polypoid cystitis in two pet rabbits
Stem Cell Reports: The Developmental Stage of Adult Human Stem Cell-Derived Retinal Pigment Epithelium Cells Influences Transplant Efficacy for Vision Rescue
EuroIntervention: Ultra-hydrophilic stent platforms promote early vascular healing and minimise late tissue response: a potential alternative to second-generation drug-eluting stents
Interventional Cardiology Clinics: Mechanisms Underlying Drug Delivery to Peripheral Arteries.
Annals of Biomedical Engineering: Stents: Biomechanics, Biomaterials, and Insights from Computational Modeling
World Pharma Today: Cell-based Therapy and FDA Review: Partnering for Success at Your pre-IND Meeting
2016
Cardiovascular Revascularization Medicine: Anatomical and Procedural Determinants of Catheter-based Renal Denervation
Interventional Cardiology Clinics: Pathology of Endovascular Stents
Interventional Cardiology Clinics: Endovascular Drug Delivery and Drug Elution Systems: First Principles
Ann Biomed Eng: Vascular Response to Experimental Stent Malapposition and Under-Expansion
Biomaterials: A tunable delivery platform to provide local chemotherapy for pancreatic ductal adenocarcinoma.
JACC Cardiology Interventions: Ridaforolimus Eluting Stents with Customizable Diffusion Controlled Release Kinetics and Tissue Uptake
Ann Biomed Eng: Sustained Efficacy and Arterial Drug Retention by a Fast Drug Eluting Cross-Linked Fatty Acid Coronary Stent Coating
Journal of Biomedical Materials Research: Applied Biomaterials: Evaluation of an intramedullary bone stabilization system using a light-curable monomer in sheep
2015
Biomaterials Forum: Embolization of Hydrophilic Coating from Catheters: Can Animal Models Predict Clinical Risk
Advanced Healthcare Materials: Tuning of collagen scaffold properties modulates embedded endothelial cell regulatory phenotype in repair of vascular injuries in vivo
J Trauma Acute Care Surg: Chronic safety assessment of hemostatic self-expanding foam: 90-day survival study and intramuscular biocompatibility
EuroIntervention: Renal sympathetic nerve denervation using intraluminal ultrasound within a cooling balloon preserves the arterial wall and reduces sympathetic nerve activity
J Endovasc Ther: Two Blades-Up Runs Using the JetStream Navitus Atherectomy Device Achieve Optimal Tissue Debulking of Nonocclusive In-Stent Restenosis: Observations From a Porcine Stent/Balloon Injury Model
ALN: A Novel Liquid Diet for Use in Swine
Sci Transl Med: Arterial microanatomy determines the success of energy-based renal denervation in controlling hypertension
EuroIntervention: Particulates from hydrophilic-coated guiding sheaths embolise to the brain
Science Translational Medicine: Regulation of dendrimer/dextran material performance by altered tissue microenvironment in inflammation and neoplasia
2014
Circ Cardiovasc Interv: Comparison of renal artery, soft tissue, and nerve damage after irrigated versus nonirrigated radiofrequency ablation
J Am Coll Cardiol: Innervation patterns may limit response to endovascular renal denervation
JACC Cardiovasc Interv: Methodological Standardization for the Pre-Clinical Evaluation of Renal Sympathetic Denervation
Cardiovascular Research: Extent of flow recirculation governs expression of atherosclerotic and thrombotic biomarkers in arterial bifurcations
J Hypertens: Evaluation of renal nerve morphological changes and norepinephrine levels following treatment with novel bipolar radiofrequency delivery systems in a porcine model.
Vascular: Preclinical evaluation of the InCraft® aortic endograft in a sheep model.
2013
Biomaterials Forum: Computational Modeling of Biomaterial Degradation and Local Drug Release Facilitates Rapid Device Development, Enhanced Performance & Regulatory Evaluation
Circulation: Mechanisms of Tissue Uptake and Retention in Zotarolimus-Coated Balloon Therapy
Journal of Histotechnology: Correlative evaluation of variable pressure-scanning electron microscopy to histology methods for vascular tissues.
2012
Journal of Invasive Cardiology: Serial Evaluation of Vascular Response After Implantation of a New Sirolimus-Eluting Stent With Bioabsorbable Polymer (MISTENT): an optical coherence tomography and histopathological study.
Langmuir: Natural Tissue Microenvironmental Conditions Modulate Adhesive Material Performance
Journal of Controlled Release: Enhanced Drug Delivery Capabilities from Stents Coated with Absorbable Polymer and Crystalline Drug
Journal of Controlled Release: Stent elution rate determines drug deposition and receptor-mediated effects
EuroIntervention: Angiographic and Histological Results Following Implantation of a Novel Stent-On-A-Wire in the Animal Model
Ann NY Acad Sci: Engineered arterial models to correlate blood flow to tissue biological response
2011
2010 and earlier
Atherosclerosis: Regulation of heparanase expression in coronary artery disease in diabetic hyperlipidemic swine
Circulation: Smooth muscle cells orchestrate the endothelial cell response to flow and injury
J Heart Lung Transplant: T-helper 2 cells are essential for modulation of vascular repair by allogeneic endothelial cells
Journal of Controlled Release: Lesion complexity determines arterial drug distribution after local drug delivery
PloS ONE: Luminal flow amplifies stent-based drug deposition in arterial bifurcations
Circulation: Vascular regeneration by local growth factor release is self-limited by microvascular clearance
Journal of Controlled Release: Intramuscular drug transport under mechanical loading: resonance between tissue function and uptake
Cell Proliferation: Diffusion-limited binding explains binary dose response for local arterial and tumor drug delivery
Circulation Research: Heparanase alters arterial structure, mechanics, and repair following endovascular stenting in mice
Journal of Controlled Release: Luminal flow patterns dictate arterial drug deposition in stent-based delivery
Journal of Controlled Release: Thrombus causes fluctuations in arterial drug delivery from intravascular stents
Cell Prolif: Phospholipase C-delta extends intercellular signalling range and responses to injury-released growth factors in non-excitable cells
Proc Natl Acad Sci U S A: Tissue engineered endothelial and epithelial implants differentially and synergistically regulate airway repair
Journal of Controlled Release: Intravascular drug release kinetics dictate arterial drug deposition, retention, and distribution
Biochem J: Endosomal receptor kinetics determine the stability of intracellular growth factor signalling complexes
Circulation: Differential Response to Vascular Stenting in Control Vs Insulin-Treated Diabetic Pigs: Analysis of Carotid, Renal and Coronary Bare Metal Stents (BMS) and Coronary Sirolimus Eluting Stents (SES)
Circ Res: Vascular neointimal formation and signaling pathway activation in response to stent injury in insulin-resistant and diabetic animals
Journal of Controlled Release: Local and systematic drug competition in drug-eluting stent tissue deposition properties
Circulation: Strut position, blood flow, and drug deposition: implications for single and overlapping drug-eluting stents
Circulation: Thrombosis modulates arterial drug distribution for drug-eluting stents
Clinical Cancer Research: Mathematical modeling and optimization of drug delivery from intratumorally injected microspheres
J Theor Biol: Analysis of compartmental models of ligand-induced endocytosis
PNAS: Specific binding to intracellular proteins determines arterial transport properties for rapamycin and paclitaxel
Circulation: Liposomal Alendronate Inhibits Systemic Innate Immunity and Reduces In-Stent Neointimal Hyperplasia in Rabbits
Medical Physics: Dose model for stent-based delivery of a radioactive compound for the treatment of restenosis in coronary arteries
Circulation: Increased thrombosis after arterial injury in human C-reactive protein-transgenic mice
Vascular Medicine: Leukocyte recruitment and expression of chemokines following different forms of vascular injury
Journal of Vascular Research: Perivascular endothelial implants inhibit intimal hyperplasia in a model of arteriovenous fistulae: a safety and efficacy study in the pig
Biophys J: Reaction diffusion model of the enzymatic erosion of insoluble fibrillar matrices
Circulation Research: Arterial ultrastructure influences transport of locally delivered drugs
J Pharm Sci: Carrier proteins determine local pharmacokinetics and arterial distribution of paclitaxel
Circulation: Physiological transport forces govern drug distribution for stent-based delivery
JACC: Neointimal thickening after stent delivery of paclitaxel: change in composition and arrest of growth over six months
Biomaterials: Correlation of transarterial transport of various dextrans with their physicochemical properties
Journal of Surgical Research: Glucagon-like peptide 2: a new treatment for chemotherapy-induced enteritis
Circulation Research: Arterial paclitaxel distribution and deposition
Circulation: Stent and artery geometry determine intimal thickening independent of arterial injury
Journal of Clinical Investigation. Decreased neointimal formation in Mac-1(-/-) mice reveals a role for inflammation in vascular repair after angioplasty
Journal of Controlled Release: Mathematical modeling of diffusion-mediated release from bulk degrading matrices
J Biomed Mater Res: Mechanisms of heparin transport through expanded poly(tetrafluoroethylene) vascular grafts
Proc Natl Acad Sci U S A: Tissue concentration of heparin, not administered dose, correlates with the biological response of injured arteries in vivo
Am J Physiol: Arterial heparin deposition: role of diffusion, convection, and extravascular space
Am J Physiol: Computational simulations of local vascular heparin deposition and distribution
Circ Res: Mechanisms of transmural heparin transport in the rat abdominal aorta after local vascular delivery
CBSET Presentations and Posters
2024
TCT 2024: Drug-Loss at Arterial Bends Can Dominate Off-Target Drug Delivery by Paclitaxel-Coated Balloons
TCT 2024: Twelve Week Safety and Efficacy of a Novel Extravascular Bi-lateral Renal Denervation Device in a Porcine Model at Nominal Dose
ESB2024: Modeling of drug-coated balloon inflation correlates drug transfer with vessel geometry and balloon design
DDW 2024: Visualization and Quantification of Acute Drug Coating Distribution on Porcine Esophagus and Common Bile Duct Surfaces After Drug Coated Balloon Treatments
EuroPCR 2024: Quantitative differentiation of vessel preparation modalities in a porcine in-stent restenosis model
ICI 2024: Porcine Model of Catheter Based Treatment of Pulmonary Embolization
2023
2023 ACVP/ASVCP Annual Meeting: Lost in the Labyrinth: A Primer on Basic Cochlear Histology for Anatomic Pathologists.
AALAS 2023: The Chinchilla Consortium: A Chinchilla Clinical Case Report Gold Mine
TCT 2023: Imaging-Based Evaluation and Differentiation of Vessel Preparation Technologies in a Porcine Model of Peripheral Artery Stenosis
TCT 2023: Ultrasound-enhanced clot thrombolysis in a porcine model of pulmonary embolism
SPS 2023: Maximizing Insights from Preclinical Safety Studies in the Context of Rising Costs and NHP Shortages
EuroPCR 2023: Ultrasound-enhanced clot thrombolysis in a porcine model of pulmonary embolism
ISID: Analyzing the effect of radiofrequency catheter ablation on tissue using a novel 3D imaging pipeline
SPS Regional 2023: Swine, the Other Tox Species
SOT: A Novel 3D Imaging Pipeline for Analyzing Radiofrequency Catheter Ablation in Preclinical Animal Models
2022
2021
CRT Online 2021: Atraumatic Endoluminal Microincisions Enhance Balloon-based Drug Delivery In Complex Porcine Restenotic Lesions
ARO 2021: Cochlear Implant: Mini Swine or Sheep? Such a Tricky Choice
LINC 2021: Lesion Modification with a Micro-Incision Vessel Preparation System Enhances Balloon-Based Drug Delivery in Complex Porcine Restenotic Lesions
2020
TCT Connect 2020: 371-Drug-Coated Balloon Contact Pressure Predicts Endoluminal Coating Distribution
Digestive Diseases Week: A novel modified jejunum model for endoscopic ultrasonography-guided biliary drainage procedures
CRT 2020: Computational Prediction Of Drug-eluting Stent Performance In Patient-specific Arteries – A Virtual Reality
CRT 2020: Six Month Safety Evaluation Of The Chocolate Touch™ Drug-coated Balloon Catheter In The Swine Peripheral Artery Model
CRT 2020: Procedural and Anatomical Determinants of Multi-Electrode Renal Denervation: Preclinical Versus Clinical
9th Bio-Fluid Symposium: Transient subject-specific drug delivery in stented arteries: physics-based simulation of controlled release and retention
ARO 2020: Large Animal Models for Auditory Research: Guide to the Perplexed
2019
ICI 2019: Multiyear Tissue Retention of Paclitaxel is Driven by Lesion Complexity: Insights from Experimentally Grounded Computational Modeling
TCT 2019: Identifying Conditions for Very Late Tissue Retention of Paclitaxel: Insights from Mechanistic Computational Modeling
TCT 2019: Quantification of Procedural and Anatomical Determinants of Multi-electrode Renal Denervation
AACR Special Conference on Pancreatic Cancer: Targeted and sustained drug delivery therapy for localized pancreatic cancer: In vivo validation in porcine models
Biointerface 2019: Swine Clot Model for the Evaluation of Mechanical Thrombectomy Devices
Biointerface 2019: Quantitative preclinical insights into procedural and anatomical determinants of multi-electrode renal denervation efficacy
STP: Ototoxicity Related to Cisplatin: Does Gender Matter?
Partnering for FDA Review: Approaches for Preclinical Outsourcing and CRO Evaluation
St. Jude’s: Partnering for FDA Review: Approaches for Preclinical Outsourcing and CRO Evaluation
EuroPCR: Evaluation of splenic artery denervation: rationale, feasibility, and early pre-clinical experience
EuroPCR: Vessel preparation system for enhanced plaque modification – Results in calcified human cadaver peripheral arteries
ATVB|PVD Scientific Sessions: In vivo Imaging Assessment of Arterial Permeability Using Indocyanine Green: Implications for Optimizing Drug-Coated Balloon Treatment of Atherosclerosis
CRT19 Best Innovation Competition: Enhanced Plaque Modification of Cadaveric Human Calcified Peripheral Arteries Treated with a Vessel Preparation System
2018
ICI 2018: Enhanced Plaque Modification of Cadaveric Human Calcified Peripheral Arteries Treated with a Dynamic Scoring Catheter
Biointerface: Immunofluorescence and Computational Methods for Tracking Tissue Distribution of Drugs in Support of Stent Coating Innovations
TCT 2018: Tracking tissue distribution and retention of Sirolimus and analog delivered from polymer free drug coated stents
TCT 2018: Superior and proximal nerves in porcine renal arteries are least accessible to radiofrequency ablation due to shielding by peri-arterial blood vessels and lymph nodes
TCT 2018: Splenic Artery Denervation: Rationale, Feasibility, and Early Pre-Clinical Experience in a Porcine Model of Inflammatory Arthritis
St. Jude’s: Serving the Gap: Combining GLP Preclinical Standards with Academic Rigor for FDA Review
EuroPCR: Local, regional, and systemic factors in BRS thrombosis in small vessels: understanding the sub-2.5mm barrier
EuroPCR: Visualizing and quantifying differential distribution of balloon-delivered coating to porcine arteries
EuroPCR: Visualizing the tissue distribution and retention of Sirolimus and analog delivered from polymer free drug coated stents
2017
Tufts CTSI Translational Day 2017: Lessons learned from the front lines
TCT 2017: Stent based tissue drug and binding target protein distributions: durable versus deployable coatings
ASR and AALAS: Benecalorie Nutritional Supplement as a Component of Liquid Diet in Swine
Academy of Surgical Research: Novel, Minimally Invasive, Toxin Administration into the Pericardial Space for the Developlment of Heart Failure in Swine
SIB 2017: Particulate embolization from catheter coatings
VIVA2017: Plaxitel-Coated PTA Balloon Catheter: microcrystalline coating for improved delivery and retention
EuroPCR: Sirolimus analog lipophilicity dictates release kinetics and tissue retention after implantation of polymer free drug coated stents
CX 2017: Peripheral Innovation: Evaluation of a novel paclitaxel-coated intravascular balloon
Society for Biomaterials: *BTI* From Benchtop to Clinical Trial: Examples of technology development
2016
ACVP: Assessment of a Novel Rabbit Atheroma Model Utilizing Combined Dietary Modification, Balloon Injury and Administration of Pro-Calcific Agents
ICI 2016: New and Revisited Targets for Autonomic Modulation: the Pathophysiology Behind
ICI 2016: Multiple drug coated balloon exposures increase arterial permeability and drug retention
MDD: Pre-clinical studies of implantable medical devices: Lessons from the front lines
TCT 2016: Multiple drug coated balloon exposures increase arterial permeability and drug retention
SNIS: Preclinical Evaluation of Mechanical Thrombectomy Devices in a Swine Clot Model
EuroPCR: Solubility-controlled sirolimus release from drug-filled stents
EuroPCR: Plaque modification with an orbital atherectomy system enhances drug distribution in calcified peripheral arteries
EuroPCR: ePTFE Balloon with a Paclitaxel-Coating Engineered for Enhanced Arterial Retention
Charing Cross: ePTFE balloon with a paclitaxel coating engineered for enhanced arterial retention: results with porcine peripheral arteries
American College of Cardiologists: Anatomical and Procedural Determinants of Catheter-based Renal Denervation
Society of Toxicology: Safety Assessment of Radiofrequency Renal Denervation in Swine
Society of Toxicology: Safety Assessment of an Intramedullary Bone Stabilization Device Using a Light-Curable Monomer
CRT 2016: Ridaforolimus Eluting Stents with Customizable Diffusion Controlled Release Kinetics and Tissue Uptake
CRT 2016: Is There a Threshold for Tissue NEPI Reduction?
Leipzig Interventional Course (LINC): Lesion modification with an orbital atherectomy system enhances paclitaxel distribution in calcified peripheral arteries
Leipzig Interventional Course (LINC): ePTFE balloon with a paclitaxel coating engineered for enhanced arterial retention: results in porcine peripheral arteries
2015
ICI 2015: Enhanced Circumferential Ablation using a Multi-electrode Bipolar/Unipolar Over-the -Wire Renal Denervation RF Catheter System with Closed Loop Sensing
ICI 2015: Ridaforolimus Eluting Stents with Predictable Diffusion Controlled Release Kinetics and Tissue Uptake
ICI 2015: Efficacy and Histomorphologic Evaluation of the Essential Medical MANTA Large Bore Vascular Closure Device in Swine
ACVP 2015: Microanatomic Determinants of Efficacy of Endovascular Radiofrequency Renal Denervation in Swine
ACVP 2015: Histopathologic Evaluation of a Novel Percutaneous Intramedullary (IM) Photodynamic Balloon Stabilization System (PBSS) in Sheep Tibia
TCT 2015: Enhanced Circumferential Ablation using a Multi-electrode Bipolar/Unipolar Over-the-Wire Renal Denervation RF Catheter System with Closed Loop Sensing
TCT 2015: Lesion preparation with an orbital atherectomy system enhances paclitaxel deposition in calcified peripheral arteries
TCT 2015: Titratable drug delivery from drug filled stents
AVMA 2015: Rabbit Spay Wet Lab
AVMA 2015: Surgical Procedures in Ferrets
AVMA 2015: Ferret Diseases
EuroPCR 2015: Primary lesion treatment with an orbital atherectomy system enhances paclitaxel deposition in calcified peripheral arteries
EuroPCR 2015: Bipolar/unipolar over-the-wire renal denervation without blood occlusion using the ReDy RF catheter system: preclinical experience
EuroPCR 2015: Safety and Biomarker Effects of a Novel Multi-electrode Over-the -Wire Renal Denervation RF Catheter in a Porcine Model
EuroPCR 2015: Mechanisms of Renal Denervation
EuroPCR 2015: The link between preclinical testing and clinical performance and outcome
Biomaterials: Drug Eluting Stents and Beyond
CRT 2015: <em><strong><a rel="noreferrer noopener" href="https://rutherfordmedicine.com/videos/Effects-Of-Orbital-Atherectomy-Treatment-F39AE9FF3" target="_blank">Effects of Orbital Atherectomy Treatment on Drug Absorption in Calcified Peripheral Arteries.</a></strong></em>
CRT 2015: Particulates from Hydrophilic Coated Guiding Sheaths Embolize to the Brain
CRT 2015: Preclinical Safety and Efficacy of a Novel Multielectrode Bipolar/Unipolar Over-the-Wire Renal Denervation RF Catheter
CRT 2015: Minimal Plaque Surface Area and Minimal Luminal Area Needed for Effective Atherectomy using the JetStream Navitus in Treating In-Stent Restenosis of Femoral Artery in a Porcine Model
CRT 2015: Intravascular Ultrasound Assessment of the Optimal Number of Runs Using the JetStream Navitus Device to Achieve Maximum Tissue Debulking in Femoral Artery in-Stent Restenosis Porcine Model
CRT 2015: Optimal Number of Runs Using the JetStream Navitus Device to Achieve Maximum Tissue Debulking of in-Stent Restenosis in a Porcine Stent/Balloon Injury Overstretch Model
CRT 2015: Ultra-Hydrophilic Stents Promote Early Healing and Minimize Late Tissue Response: A Potential Alternative to Second-Generation Drug Eluting Stents
2014
Innovations in Cardiovascular Interventions: Asymmetric Renal Artery Innervation Patterns May Limit the Efficacy of Endovascular Radiofrequency Ablation
ASCVP: Particulates from hydrophilic coated guiding sheaths embolize to the brain
AALAS:Monitoring and Maintenance of an Azotemic Environment in an Acute Renal Failure Model in Swine
AALAS: Chronic Unilateral Ear Droop in a Male Yucatan Miniature Swine
AALAS: Liquid Diet Use in Swine
AALAS: Zoonotis Endoparasites in Research Swine Obtained from Class A Vendors
Academy of Surgical Research: Monitoring and Maintenance of an Azotemic Environment in an Acute Renal Failure Model in Swine
TCT 2014: Renal Norepinephrine Reduction Following Radiofrequency Renal Denervation Correlates with Extent of Nerve Ablation: Roles of Ablation Areas, Anatomy, and Number of Treatments
TCT 2014: Innervation Patterns in the Renal Artery Ostium May Limit the Efficacy of Endovascular Radiofrequency Ablation
TCT 2014: Particulates from hydrophilic coated guiding sheaths embolize to the brain
Swine in Biomedical Research: Liquid Diet Use in Swine
Swine in Biomedical Research: Zoonotis Endoparasites in Research Swine Obtained from Class A Vendors
Swine in Biomedical Research: Monitoring and Maintenance of an Azotemic Environment in an Acute Renal Failure Model in Swine
FDA-MDIC: Computational modeling of local stent pharmacokinetics: Replacement, Reduction Refinement, and Return on Investment
EuroPCR 2014: Particulates from hydrophilic coated guiding sheaths embolize to the brain
EuroPCR 2014: Electrode irrigation protects the artery wall while maintaining injury to renal nerves
EuroPCR 2014: The unique anatomy of renal arterial ostium may limit efficacy of endovascular radiofrequency ablation
Annual Meeting of the Society for Biomaterials: Intramedullary Bone Stabilization Device Using a Light-Curable Monome
Annual Meeting of the Society for Biomaterials: Drug Delivery from Coated Balloons: Drug Loading Density and Transfer Rate Determine Peak Tissue Content, Binding Determines Sustained Tissue Retention
Annual Meeting of the Society for Biomaterials: Computational modeling of local cardiovascular therapies: state of the art and regulatory perspectives
2013
TCT 2013: Electrode irrigation alters RF ablation treatment zone geometry and preserves medial and adventitial tissue while maintaining injury to renal nerves
FDA – ASME Frontiers in Medical Devices: Computational Modeling Accurately Predicts In Vivo Arterial Elimination of Sirolimus-Analog Eluting Stents
Boston AF Symposium: Microbubble and Emboli Production from Left Atrial Ablation with an RF Mesh Ablation System vs. Irrigated Tip Ablation: Outcomes of an Extracorporeal Loop Swine Model
TRENDS: Systematic Optimization of Targeted Renal Denervation Therapies Using the Porcine Model: Integration of quantitative biomarker analysis, computer modeling, and histopathologic techniques
Annual Meeting of the Society for Biomaterials: Understanding the Influence of Stent Design on Arterial Drug Distribution and Effect through Computational Modeling
2012
TCT 2012: Stents with absorbable tissue-deployable coatings can distribute drug more uniformly between struts
TCT 2012: A Novel Bioactive and Coating-Free Stent Surface Exhibits a Reduction in Neointimal Hyperplasia by Decreasing Platelet Aggregation and Promoting Endothelialization
Annual National Society for Histotechnology: Correlative evaluation of variable pressure-scanning electron microscopy to histology methods for vascular tissues
American Society for Artificial Internal Organs: In Vivo Study of a Rotary Blood Pump System to Enhance Arteriovenous Fistula Eligibility
2011
TCT 2011: Systemic and Local Tissue Pharmacokinetics of Single and Overlapping NEVOTM Sirolimus Eluting Stents in the Porcine Coronary Artery Model
TCT 2011: Serial Evaluation of the Vascular Response After Implantation Of a New Sirolimus-Eluting Stent with Bioabsorbable Polymer (MiStent® DES) – an Optical Coherence Tomography and Histopathological Study
1st Modeling Barrier Membranes Research Conference: Local drug delivery to the arterial wall: integrating pharmacology with drug transport
FDA/NHLBI/NSF: Stent Elution Rate Determines Sirolimus Deposition and Binding
Academy of Surgical Research: An Alternative Approach to Venous Access for Large Diameter Catheters and Devices in the Swine Model: Using the Iliac Vein
2010 and earlier
TCT 2010: Multi-scale modeling in local drug delivery: Implications for the evaluation of drug eluting stents and balloon technologies
TCT 2010: A Comprehensive Analysis of DES and Bare Metal Stents Using Morphometric SEM Images of Overlapping Stent Pairs in a Rabbit Iliac Model to Assess Overall Healing
AngioAccess for Hemodialysis: Topical Elastase Increases AVG Outflow Vein Diameter and Lumen Area in a Swine Model
FDA/NHLBI/NSF : Computational Model Predicts Multi-Phasic Drug Elution Kinetics From Bulk Degrading Inlays in Stent Reservoirs
TCT 2009: Effect of Stent Design on Endothelialization in the Rabbit Iliac Model
Vascular Access Society 6th International Congress: Recombinant Human Pancreatic Elastase (PRT-201) Dilates the Arteriovenous Graft (AVG) Outflow Vein and Increases Graft Blood Flow in a Porcine Femoral AVG Model
Saturable Drug Binding Explains the Dose and Tissue Dependence of Stent Delivery.’ FDA/NHLBI/NSF Workshop on Computer Methods for Cardiovascular Devices: Saturable Drug Binding Explains the Dose and Tissue Dependence of Stent Delivery
American Society of Nephrology: Local Application of Recombinant Human Type I Pancreatic Elastase (PRT-201) to an Arteriovenous Fistula (AVF) Increases AVF Blood Flow in a Rabbit Model
TCT 2006 : Dissociating DES safety & efficacy: Endothelial regrowth & drug effect after abluminal or circumferential paclitaxel delivery from bioerodable polymer in porcine coronaries
TCT 2006 : Self-expanding Coronary Stents Entirely Incorporated within an 0.014” Wire: Late Lumen Gain 90 days after Porcine Coronary Artery Implantation
TCT 2005: Total Paclitaxel Dose Optimization With Minimized Abluminal Bioerodable Polymer Stent Coatings Provides Safe Delivery of Paclitaxel in Porcine Coronary Arteries
TCT 2004: Abluminal bioerodable polymer stent coating, applicable at point-of-care, provides safe delivery of paclitaxel in porcine coronary arteries
