Martorell, Santomá, Kolandaivelu, Kolachalama, Melgar-Lesmes, Molins, García, Edelman, Balcells. Extent of flow recirculation governs expression of atherosclerotic and thrombotic biomarkers in arterial bifurcations.

Summary: Atherogenesis, evolution of plaque, and outcomes following endovascular intervention depend heavily on the unique vascular architecture of each individual. Patient-specific, multiscale models able to correlate changes in microscopic cellular responses with relevant macroscopic flow, and structural conditions may help understand the progression of occlusive arterial disease, providing insights into how to mitigate adverse responses in specific settings and individuals.

Cardiovasc Res. 2014 Jul 1;103(1):37-46