J Heart Lung Transplant: T-helper 2 cells are essential for modulation of vascular repair by allogeneic endothelial cells

Methe H, Nanasato M, Spognardi AM, Groothuis A, Edelman ER. . T-helper 2 cells are essential for modulation of vascular repair by allogeneic endothelial cells.

Summary: Endothelial cells (EC) embedded within three-dimensional matrices (MEEC) when placed in the vascular adventitia control lumenal inflammation and intimal hyperplasia. Matrix-embedding alters endothelial immunogenicity in vitro. T helper (Th) driven host immunity is a major impediment for of allogeneic grafts. We therefore aimed to identify if modulation of T helper balance would affect immune compatibility and endothelial regulation of vascular repair in vivo.

J Heart Lung Transplant. 2010 Apr; 29(4):479-86.