O’Brien CC, Lopes AC, Kolandaivelu K, Kunio M, Brown J, Kolachalama VB, Conway C, Bailey L, Markham P, Costa M, Ware J, Edelman ER. Vascular Response to Experimental Stent Malapposition and Under-Expansion. Summary: Up to 80% of all endovascular stents have malapposed struts, and while some impose catastrophic events others are inconsequential. Thirteen stents were implanted […]
Category Archives: Publications
Biomaterials: A tunable delivery platform to provide local chemotherapy for pancreatic ductal adenocarcinoma.
Indolfi L, Ligorio M, Ting DT, Xega K, Tzafriri AR, Bersani F, Aceto N, Thapar V, Fuchs BC, Deshpande V, Baker AB, Ferrone CR, Haber DA, Langer R, Clark JW, Edelman ER. A tunable delivery platform to provide local chemotherapy for pancreatic ductal adenocarcinoma. Summary: Pancreatic ductal adenocarcinoma (PDAC) is one of the most devastating and […]
JACC Cardiology Interventions: Ridaforolimus Eluting Stents with Customizable Diffusion Controlled Release Kinetics and Tissue Uptake
Tzafriri AR, Markham PM, LaRochelle AW, Spognardi AM, Bailey L, Cohen I, Elmalak O, Richter Y, Edelman ER. ‘Ridaforolimus Eluting Stents with Customizable Diffusion Controlled Release Kinetics and Tissue Uptake.’ Poster presentation at: Cardiovascular Research Technologies (CRT); 2016 Feb 20-23; Washington, DC. Background Drug release from spray coatings applied to cylindrical stents is difficult to customize […]
Ann Biomed Eng: Sustained Efficacy and Arterial Drug Retention by a Fast Drug Eluting Cross-Linked Fatty Acid Coronary Stent Coating
Artzi N, Tzafriri AR, Faucher KM, Moodie G, Albergo T, Conroy S, Corbeil S, Martakos P, Virmani R, Edelman ER. Sustained Efficacy and Arterial Drug Retention by a Fast Drug Eluting Cross-Linked Fatty Acid Coronary Stent Coating. Summary: The long held assumption that sustained drug elution from stent coatings over weeks to months is imperative for […]
Journal of Biomedical Materials Research: Applied Biomaterials: Evaluation of an intramedullary bone stabilization system using a light-curable monomer in sheep
Zani BG, Baird R, Stanley JR, Markham PM, Wilke M, Zeiter S, Beck A, Nehrbass D, Kopia GA, Edelman ER, Rabiner R. Evaluation of an intramedullary bone stabilization system using a light-curable monomer in sheep. Abstract: Percutaneous intramedullary fixation may provide an ideal method for stabilization of bone fractures, while avoiding the need for large […]
Biomaterials Forum: Embolization of Hydrophilic Coating from Catheters: Can Animal Models Predict Clinical Risk
Tzafriri, AR, Stanley, JR. ‘Embolization of Hydrophilic Coating from Catheters: Can Animal Models Predict Clinical Risk?’ Summary: Medical catheters permit minimally invasive external access for monitoring, imaging, sampling and local delivery of therapeutic agents, and placement of devices like endovascular stents, aneurysm coils and transcatheter valves. To improve ease of manipulation and deliverability the exterior surfaces […]
Advanced Healthcare Materials: Tuning of collagen scaffold properties modulates embedded endothelial cell regulatory phenotype in repair of vascular injuries in vivo
Unterman S, Freiman A, Beckerman M, Abraham E, Stanley JR, Levy E, Artzi N, Edelman E. Tuning of collagen scaffold properties modulates embedded endothelial cell regulatory phenotype in repair of vascular injuries in vivo. Summary: Perivascularly implanted matrix embedded endothelial cells (MEECs) are potent regulators of inflammation and intimal hyperplasia following vascular injuries. Endothelial cells […]
J Trauma Acute Care Surg: Chronic safety assessment of hemostatic self-expanding foam: 90-day survival study and intramuscular biocompatibility
Rago A, Duggan MJ, Hannett P, Brennecke LH, LaRochelle A, Khatri C, Zugate GT, Chang Y, SharmaU, King DR. Chronic safety assessment of hemostatic self-expanding foam: 90-day survival study and intramuscular biocompatibility. Summary: Noncompressible hemorrhage is a significant cause of preventable death in trauma, with no effective presurgical treatments. We previously described the efficacy and 28-day […]
EuroIntervention: Renal sympathetic nerve denervation using intraluminal ultrasound within a cooling balloon preserves the arterial wall and reduces sympathetic nerve activity
Pathak A, Coleman L, Roth A, Stanley J, Bailey L, Markham P, Ewen S, Morel C, Despas F, Honton B, Senard JM, Fajadet J, Mahfoud F. Renal sympathetic nerve denervation using intraluminal ultrasound within a cooling balloon preserves the arterial wall and reduces sympathetic nerve activity. Summary: Catheter-based ultrasound delivered within a cooling balloon is effective […]
J Endovasc Ther: Two Blades-Up Runs Using the JetStream Navitus Atherectomy Device Achieve Optimal Tissue Debulking of Nonocclusive In-Stent Restenosis: Observations From a Porcine Stent/Balloon Injury Model
Shammas NW, Aasen N, Bailey L, Budrewicz J, Farago T, Jarvis G. Two Blades-Up Runs Using the JetStream Navitus Atherectomy Device Achieve Optimal Tissue Debulking of Nonocclusive In-Stent Restenosis: Observations From a Porcine Stent/Balloon Injury Model. Summary: JetStream Navitus achieved optimal tissue debulking after 2 BD and 2 BU runs with no further statistical gain in […]