Circulation: Arrhythmia and Electrophysiology: Pulsed Field Ablation Using a Lattice Electrode for Focal Energy Delivery: Biophysical Characterization, Lesion Durability, and Safety Evaluation

Hagai Yavin, Ayelet Shapira-Daniels, Michael Barkagan, Jakub Sroubek, David Shim, Raffaele Melidone, Elad Anter. “Pulsed Field Ablation Using a Lattice Electrode for Focal Energy Delivery: Biophysical Characterization, Lesion Durability, and Safety Evaluation.” Summary: Pulsed field ablation (PFA) is a nonthermal energy that may provide safety advantages over radiofrequency ablation (RFA). One-shot PFA catheters have been developed […]

Circulation: Mortality and Paclitaxel-Coated Devices: An Individual Patient Data Meta-Analysis

Krishna J. Rocha-Sing , Sue Duval, Michael R. Jaff, Peter A. Schneider, Gary M. Ansel, Sean P. Lyden, Christopher M. Mullin, John P.A. Ioannidis, Sanjay Misra, Abraham R. Tzafriri, Elazer R. Edelman, Juan F. Granada, Christopher J. White, and Joshua A. Beckman. “Mortality and Paclitaxel-Coated Devices: An Individual Patient Data Meta-Analysis.” Summary: Paclitaxel-containing devices (PTXD) significantly […]

Biomedical Instrumentation & Technology: Analysis: Intravascular Devices with a Higher Risk of Polymer Emboli: The Need for Particulate Generation Testing

Chopra AM, Rapkiewicz A, Daggubati R, Sequeira A, Hu YC, Bhatt DL, Sharma SK, Cruz JP, Tzafriri AR, Edelman ER. “Analysis: Intravascular Devices with a Higher Risk of Polymer Emboli: The Need for Particulate Generation Testing.” Summary: Hydrophilic polymer coatings on intravascular devices lower friction between the device and vasculature, thereby reducing trauma during interventional procedures. […]

Journal of Neuerointerventional Surgery: Preclinical evaluation of the ANCD thrombectomy device: safety and efficacy in a swine clot model

Sanchez S, Bailey L, Ducore R, Andersson T, Nogueira R, Cognard C, Ribo M, Villanova H, Rios A, Galve I. “Preclinical evaluation of the ANCD thrombectomy device: safety and efficacy in a swine clot model” Summary: The Advanced Thrombectomy System (ANCD) provides a new funnel component designed to reduce clot fragmentation and facilitate retrieval in patients […]

Journal of Controlled Release: Taking paclitaxel coated balloons to a higher level: Predicting coating dissolution kinetics, tissue retention and dosing dynamics

Abraham R.Tzafriri, Sahil A.Parikh, Elazer R.Edelman. “Taking paclitaxel coated balloons to a higher level: Predicting coating dissolution kinetics, tissue retention and dosing dynamics.” Summary: Paclitaxel coated balloons (PCBs) are a promising non-implantable alternative to drug-eluting stents, whereby drug is delivered to the arterial wall in solid form as a semi-continuous solid coating or as micro drug […]

Lymphat Res Biol: Development of a Porcine Lymph Drainage Model to Study Particle Migration

Spenciner DB, Barber FA, Zani BG, Melidone R, Muench TR. “Development of a Porcine Lymph Drainage Model to Study Particle Migration.” Summary: Intra-articular wear particulate migration from the knee joint has been studied in various animal models as well as postmortem in patients who received total knee joint replacement. However, there still exists a need […]

Translational Research: Splenic artery denervation: target micro-anatomy, feasibility, and early preclinical experience

Mazen Albaghdadi, Fernando Garcia-Polite, Brett Zani, John Keating, Raffaele Melidone, Anna Spognardi, Peter Markham, Abraham Tzafriri. “Splenic artery denervation: target micro-anatomy, feasibility, and early preclinical experience.” Summary: This study sought to evaluate perisplenic artery nerve distribution and the feasibility of splenic artery denervation (SDN). The NEXION radiofrequency catheter was used to perform SDN in healthy and […]

Hypertension: Procedural and Anatomical Determinants of Multielectrode Renal Denervation Efficacy

Hypertension editors selected this paper for their 2019 Fall Collection of High Impact Papers. Tzafriri AR, Mahfoud F, Keating JH, Spognardi AM, Markham PM, Wong G, Highsmith D, O’Fallon P, Fuimaono K, Edelman ER. Procedural and Anatomical Determinants of Multielectrode Renal Denervation Efficacy. Summary: Radiofrequency renal denervation is under investigation for treatment of hypertension with […]

EuroIntervention: Pulmonary Artery Denervation Using Catheter based Ultrasonic Energy.

Rothman A, Jonas M, Castel D, Tzafriri AR, Traxler H, Shav D, Leon MB, Ben-Yehuda O, Rubin L. “Pulmonary Artery Denervation Using Catheter based Ultrasonic Energy.” Summary: Pulmonary arterial hypertension is a devastating disease characterized by pulmonary vascular remodeling and right heart failure. Radio-frequency pulmonary artery denervation (PDN) improves pulmonary hemodynamics in pre-clinical and early clinical […]