Safety and efficacy of flowable microfibrillar collagen hemostat in an ovine model of lumbar laminectomy and open durotomy compared with the gelatin-thrombin hemostatic matrix and control. Amie Rossi, Kasia Bradbury, Kingsley Abode-Iyamah, Angela Bohnen, Darcy Gagne. Background: Effective hemostasis in spinal surgery is critical, especially near sensitive structures such as the spinal cord and dorsal […]
SA Goraya, AR Tzafriri, CRG Guttmann, FR Nezami. “Current modeling approaches for drug delivery to the central nervous system” Summary: Central nervous system (CNS) disorders pose a major global health challenge, yet therapeutic development is impeded by the difficulty of delivering effective drug concentrations to the brain. Based on a literature search of PubMed, Scopus, […]
RE Zale, ER Edelman. “Cardiorenal Hemodynamic Coupling: Mechanical Circulatory Support Augments Renal Blood Flow via Renal Vasodilation” Summary: Robust cardiorenal hemodynamic coupling influences outcomes in cardiogenic shock (CS), with concomitant renal failure a persistent challenge despite the use of mechanical circulatory support (MCS). The authors investigated cardiorenal hemodynamic coupling during progressive left ventricular failure and […]
JO Marx, J Lofgren, AL Miller, T Martin, D Eshar, T Trumble, M Williams-Fritze, J Smith, BD Pallas, L Krueger, A Blaney, C Pacharinsak. Laboratory Animal Medicine: Chapter 24 – Anesthesia, Analgesia, and Euthanasia Abstract: Anesthesia and analgesia are two of the most important tools in biomedical research. They enable veterinarians and researchers to perform […]
R Tzafriri, SA Parikh, ER Edelman. “Endovascular Drug Delivery from Stents and Balloons in Peripheral Arteries: What Every Interventionalist Must Know” Synopsis: The effective and safe delivery of drugs to arterial targets via endovascular devices is governed by several key principles. These include the concepts of dissolution, diffusion and convection, drug binding (specific and non-specific), […]
Safety and efficacy of flowable microfibrillar collagen hemostat in an ovine model of craniectomy with intraparenchymal defect compared to gelatin-thrombin hemostatic matrix. Darcy Gagne, Kasia Bradbury, Angela Bohnen, Kingsley Abode-Iyamah, Amie Rossi. Background: Flowable hemostatic agents offer advantages in confined surgical spaces, particularly in neurosurgery. However, data on microfibrillar collagen hemostats (MCH) in these applications […]
Hearing loss is a major global health challenge, affecting more than 1.5 billion people worldwide. While many medicines deliver life-changing benefits, more than 200 commonly used drugs can unintentionally cause ototoxicity, damage to the inner ear that may lead to lasting hearing problems. Ototoxicity can manifest in many ways: hearing loss, tinnitus (ringing in the […]
Feasibility and pharmacokinetic evaluation of a needle-free injector for delivering high concentration antibody formulations. A Josowitz, AS Manoj, D Laiacona, M Pelletier, D Molano, S Jennings, C Ng, CAntoni, G Chan, R Mahoney, S Patel, E-M Koehler-Stec, M Retter, J Kantrowitz, B Rayaprolu, E Holowka, AS Bhalla, M Shameem. This research report presents the evaluation […]
In drug development, the journey from bench to bedside is rarely a straight path. Many promising therapies deliver exceptional results in rodents, only to falter in human trials. These failures are costly, not just in terms of R&D budgets, but also in lost time and delayed access to potentially life-changing treatments for patients. The reason […]
by Ellie Khadir, DVM, PhD, Scientist & Study Director, CBSET and Lise Byelyayeva, MSc, Associate Director, Sales, Funding, & New Partnerships, Cilcare Hearing loss is a significant public health issue affecting over 466 million people globally. Hearing aids and cochlear implants fail to address the underlying causes. Gene therapy targets the fundamental genetic causes of […]