Science Translational Medicine: Dynamic load modulation predicts right heart tolerance of left ventricular cardiovascular assist in a porcine model of cardiogenic shock

Kimberly K. Lamberti, Steven P. Keller, Elazer R. Edelman. Dynamic load modulation predicts right heart tolerance of left ventricular cardiovascular assist in a porcine model of cardiogenic shock. Ventricular assist devices (VADs) offer mechanical support for patients with cardiogenic shock by unloading the impaired ventricle and increasing cardiac outflow and subsequent tissue perfusion. Their ability […]

American Journal of Physiology: Decreased LPS-induced lung injury in pigs treated with a lung surfactant protein A-derived nonapeptide that inhibits peroxiredoxin 6 activity

Aron B. Fisher, Brett Zani, Thomas Han, Chandra Dodia, Raffaele Melidone, Steven Keller. Decreased LPS-induced lung injury in pigs treated with a lung surfactant protein A-derived nonapeptide that inhibits peroxiredoxin 6 activity. This study addressed the efficacy of a liposome-encapsulated 9 amino acid peptide (PIP-2) for the prevention or treatment of acute lung injury (ALI) […]

Bioengineering: Cardiovascular Tissue Engineering Models for Atherosclerosis Treatment Development

Linnea Tscheuschner, Abraham R. Tzafriri. Cardiovascular Tissue Engineering Models for Atherosclerosis Treatment Development. In the early years of tissue engineering, scientists focused on the generation of healthy-like tissues and organs to replace diseased tissue areas with the aim of filling the gap between organ demands and actual organ donations. Over time, the realization has set […]

Annals of Biomedical Engineering: Investigating Balloon-Vessel Contact Pressure Patterns in Angioplasty: In Silico Insights for Drug-Coated Balloons

Stratakos E, Antonini L, Poletti G, Berti F, Tzafriri AR, Petrini L, Pennati G. Investigating Balloon-Vessel Contact Pressure Patterns in Angioplasty: In Silico Insights for Drug-Coated Balloons. Drug-coated balloons have shown promising results as a minimally invasive approach to treat stenotic arteries, but recent animal studies have revealed limited, non-uniform coating transfer onto the arterial […]

EuroIntervention: Histological examination of renal nerve distribution, density, and function in humans

Helge Struthoff, Lucas Lauder, Mathias Hohl, Alexander Hermens, Abraham Rami Tzafriri, Elazer R Edelman, Michael Kunz, Michael Böhm, Thomas Tschernig, Felix Mahfoud. “Histological examination of renal nerve distribution, density, and function in humans” Background: Renal denervation is optimised when guided by knowledge of nerve distribution. Aims: We aimed to assess sympathetic nerve distribution along the […]

Journal of Immunology and Regenerative Medicine: Early tissue growth and cell fate determination following segmental esophageal repair using a tissue engineered esophageal implant composed of a polyurethane scaffold seeded with autologous adipose-derived mesenchymal stromal cells

Sumati Sundaram, Karissa L. Paquin, Tina Roffidal, Greg Booker, Sherif Soliman, Jeff Bouchard, Elisaveta Todorova, Brett G. Zani, Raffaele Melidone, Saverio La Francesca, and William Fodor. “Early tissue growth and cell fate determination following segmental esophageal repair using a tissue engineered esophageal implant composed of a polyurethane scaffold seeded with autologous adipose-derived mesenchymal stromal cells.” […]

Frontiers in Gastroenterology: Comparison of PuraStat self-assembling peptide hydrogel versus mineral-based Hemospray for endoscopic hemostasis of upper and lower gastrointestinal lesions in pigs

Lisa Spirio, Eun Seok Gil, Kate O’neill, Elton Aleksi, Jay Budrewicz, and Raffaele Melidone. “Comparison of PuraStat self-assembling peptide hydrogel versus mineral-based Hemospray for endoscopic hemostasis of upper and lower gastrointestinal lesions in pigs.” Objective: To compare a RADA16-based self-assembling peptide hydrogel versus an inorganic powder-based spray device for controlling postoperative bleeding in upper and […]

BJU International: Evaluation of fluid absorption during flexible ureteroscopy in an in vivo porcine model

Christina Kottooran, Jeffrey Twum-Ampofo, Jason Lee, Jennifer Saunders, Marle Franco, Jay Budrewicz, Brian H Eisner. “Evaluation of fluid absorption during flexible ureteroscopy in an in vivo porcine model.” Objective: The purpose of this study was to evaluate the relationship between renal pelvis pressure and fluid absorption during ureteroscopy in a live porcine model. Materials and […]

Scientific Reports: Morphometric analysis of the human common hepatic artery (CHA) reveals a rich and accessible target for sympathetic liver denervation

Abraham Rami Tzafriri PhD, Fernando Garcia-Polite PhD, John Keating DVM DACVP, Raffaele Melidone DVM DACVP, Jennifer Knutson BS, Peter Markham MS, Elazer R. Edelman MD PhD, Felix Mahfoud MD. “Morphometric analysis of the human common hepatic artery (CHA) reveals a rich and accessible target for sympathetic liver denervation.” FULL ARTICLE Summary: Treatment of type 2 […]

Annual International Conference of the IEEE Engineering in Medicine & Biology Society: An in silico trials platform for the evaluation of effect of the arterial anatomy configuration on stent implantation

Georgia S Karanasiou, Panagiota I Tsompou, Nikolaos Tachos, Gianna E Karanasiou, Antonis Sakellarios, Savvas Kyriakidis, Luca Antonini, Giancarlo Pennati, Lorenza Petrini, Frank Gijsen, Farhad Rikhtegar Nezami, Rami Tzafriri, Martin Fawdry, Dimitrios I Fotiadis. “An in silico trials platform for the evaluation of effect of the arterial anatomy configuration on stent implantation.” Abstract: The introduction of […]