by Ellie Khadir, DVM, PhD, Scientist & Study Director, CBSET and Lise Byelyayeva, MSc, Associate Director, Sales, Funding, & New Partnerships, Cilcare Hearing loss is a significant public health issue affecting over 466 million people globally. Hearing aids and cochlear implants fail to address the underlying causes. Gene therapy targets the fundamental genetic causes of […]
QP Pham, JV Groom II, C Sadasivan, DJ Fiorella, DC Madoff, L-J Guo, M Fornaciari, C Guertin, C Wiltsey, L Core, J Merlo, W Wustenberg, R Virmani, AS Arthur, RS Langer, GM Whitesides, U Sharma. An In Situ Curing, Shear-Responsive Biomaterial Designed for Durable Embolization of Microvasculature. Abstract: Endovascular embolization is a minimally-invasive technique whereby […]
DH Gagne, CC Steele, J Keating, K Bradbury, A Badhwar, SF Elahi. Preliminary Study of Yucatan Porcine Breast Morphology: Identifying Basic Differences and Similarities for Surgical Model Applications. Background/Objectives: The porcine mammary anatomy is poorly characterized, and structures are difficult to differentiate macroscopically, unlike human mammary tissue. The objective of this exploratory study was to […]
L Tscheuschner, E Stratakos, M Kostakis, M Gravanis, M Katsimpoulas, G Pennati, F Sigala, AR Tzafriri. Drug Loss at Arterial Bends Can Dominate Off-Target Drug Delivery by Paclitaxel-Coated Balloons. Background: Paclitaxel-coated balloons (PCBs) can deliver efficacious drug concentrations to treated arterial segments but are known to exhibit high tracking losses. We aimed to define the […]
Jessica L. Grimsby, Matthew D. Szkolnicki, Kevin A. Wood. Reevaluation of an Established In Vivo Gastric Vessel Bleed Model for Hemostatic Device Safety and Efficacy Testing This study was overseen by the CBSET Inc. Contract Research Organization’s (Lexington, MA, USA.) Institutional Animal Care and Use Committee (IACUC) and conformed to the “Guide for the Care […]
E Stratakos, L Tscheuschner, L Vincenzi, E Pedrinazzi, F Sigala, L D’Andrea, D Gastaldi, F Berti, A R Tzafriri, G Pennati . A Novel In Silico–Ex Vivo Model for Correlating Coating Transfer to Tissue with Local Drug-Coated Balloon-Vessel Contact Pressures Drug-coated balloons (DCBs) aim to deliver drug-loaded surface coating upon inflation at specific vascular sites, […]
David Hinojosa-Gonzalez, Christina Kottooran, Jennifer Saunders, Erin L. Chaussee, Jay Budrewicz, Brian H. Eisner. “Relationship between renal pelvis pressure and post-ureteroscopy infection in a live swine model.” Objective: To evaluate the relationship between renal pelvis pressure and infection after ureteroscopy, using a live swine model. Materials and Methods: In anaesthetised pigs, a 1-h ureteroscopy […]
Gokhan Gundogdu, Jay Budrewicz, Jodie Giordano, Raffaele Melidone, Chris Searcy, Vikas Agarwal, Carlos R Estrada, Joshua R Mauney. “Evaluation of bi-layer silk fibroin grafts for onlay urethroplasty in a rabbit model of urethral stricture disease.” Background: Autologous tissues such as buccal mucosa (BM) are widely used for reconstruction of urethral strictures; however, limitations such as […]
Donald Hodges, Michael Stonerook, Dany Salvail, Sandrine Lemouton. Maximizing insights from nonclinical safety studies in the context of rising costs and changing regulations. Abstract: The traditional paradigm of non-rodent safety assessment studies, primarily reliant on non-human primates (NHPs) and dogs, is undergoing a transformation. During the 2023 Safety Pharmacology Society Annual Meeting, scientists from leading […]
Gonzalo Muñoz Taboada, Daniel Dahis, Pere Dosta, Elazer Edelman, Natalie Artzi. Sprayable Hydrogel Sealant for Gastrointestinal Wound Shielding. Abstract: Naturally occurring internal bleeding, such as in stomach ulcers, and complications following interventions, such as polyp resection post-colonoscopy, may result in delayed (5–7 days) post-operative adverse events—such as bleeding, intestinal wall perforation, and leakage. Current solutions […]