Gokhan Gundogdu, Jay Budrewicz, Jodie Giordano, Raffaele Melidone, Chris Searcy, Vikas Agarwal, Carlos R Estrada, Joshua R Mauney. “Evaluation of bi-layer silk fibroin grafts for onlay urethroplasty in a rabbit model of urethral stricture disease.” Background: Autologous tissues such as buccal mucosa (BM) are widely used for reconstruction of urethral strictures; however, limitations such as […]
Category Archives: Publications
Journal of Pharmacological and Toxicological Methods: Maximizing insights from nonclinical safety studies in the context of rising costs and changing regulations
Donald Hodges, Michael Stonerook, Dany Salvail, Sandrine Lemouton. Maximizing insights from nonclinical safety studies in the context of rising costs and changing regulations. Abstract: The traditional paradigm of non-rodent safety assessment studies, primarily reliant on non-human primates (NHPs) and dogs, is undergoing a transformation. During the 2023 Safety Pharmacology Society Annual Meeting, scientists from leading […]
Advanced Materials: Sprayable Hydrogel Sealant for Gastrointestinal Wound Shielding
Gonzalo Muñoz Taboada, Daniel Dahis, Pere Dosta, Elazer Edelman, Natalie Artzi. Sprayable Hydrogel Sealant for Gastrointestinal Wound Shielding. Abstract: Naturally occurring internal bleeding, such as in stomach ulcers, and complications following interventions, such as polyp resection post-colonoscopy, may result in delayed (5–7 days) post-operative adverse events—such as bleeding, intestinal wall perforation, and leakage. Current solutions […]
BJU International: A novel technique for measurement of fluid absorption during ureteroscopy
Juliana Villanueva-Congote, David Hinojosa-Gonzalez, Michal Segall, Jennifer Saunders, Jay Budrewicz, Brian H. Eisner. Evaluation of fluid absorption during flexible ureteroscopy in an in vivo porcine model. Objective: To evaluate the relationship between renal pelvis pressure and fluid absorption during ureteroscopy (URS) in a live porcine model. Materials and Methods: Flexible URS (fURS) was performed in anaesthetised […]
Frontiers in Molecular Neuroscience: Ototoxicity: a high risk to auditory function that needs to be monitored in drug development
Marie-Pierre Pasdelou, Lise Byelyayeva, Susanna Malmström, Sylvie Pucheu, Marie Peytavy, Hugo Laullier, Donald B. Hodges, Abraham R. Tzafriri, Gaëlle Naert. Ototoxicity: a high risk to auditory function that needs to be monitored in drug development. The aim of this publication is to raise awareness of drug-induced ototoxicity and to formulate some recommendations based on available […]
ASAIO Journal: Steady Flow Left Ventricle Unloading Is Superior to Pulsatile Pressure Augmentation Venting During Venoarterial Extracorporeal Membrane Oxygenation Support
Goffer, Efrat M.; Lamberti, Kimberly K.; Spognardi, Anna-Maria; Edelman, Elazer R.; Keller, Steven P. Steady Flow Left Ventricle Unloading Is Superior to Pulsatile Pressure Augmentation Venting During Venoarterial Extracorporeal Membrane Oxygenation Support Abstract Venoarterial extracorporeal membrane oxygenation (VA-ECMO) shunts venous blood to the systemic arterial circulation to provide end-organ perfusion while increasing afterload that may […]
Science Translational Medicine: Dynamic load modulation predicts right heart tolerance of left ventricular cardiovascular assist in a porcine model of cardiogenic shock
Kimberly K. Lamberti, Steven P. Keller, Elazer R. Edelman. Dynamic load modulation predicts right heart tolerance of left ventricular cardiovascular assist in a porcine model of cardiogenic shock. Ventricular assist devices (VADs) offer mechanical support for patients with cardiogenic shock by unloading the impaired ventricle and increasing cardiac outflow and subsequent tissue perfusion. Their ability […]
American Journal of Physiology: Decreased LPS-induced lung injury in pigs treated with a lung surfactant protein A-derived nonapeptide that inhibits peroxiredoxin 6 activity
Aron B. Fisher, Brett Zani, Thomas Han, Chandra Dodia, Raffaele Melidone, Steven Keller. Decreased LPS-induced lung injury in pigs treated with a lung surfactant protein A-derived nonapeptide that inhibits peroxiredoxin 6 activity. This study addressed the efficacy of a liposome-encapsulated 9 amino acid peptide (PIP-2) for the prevention or treatment of acute lung injury (ALI) […]
Bioengineering: Cardiovascular Tissue Engineering Models for Atherosclerosis Treatment Development
Linnea Tscheuschner, Abraham R. Tzafriri. Cardiovascular Tissue Engineering Models for Atherosclerosis Treatment Development. In the early years of tissue engineering, scientists focused on the generation of healthy-like tissues and organs to replace diseased tissue areas with the aim of filling the gap between organ demands and actual organ donations. Over time, the realization has set […]
Annals of Biomedical Engineering: Investigating Balloon-Vessel Contact Pressure Patterns in Angioplasty: In Silico Insights for Drug-Coated Balloons
Stratakos E, Antonini L, Poletti G, Berti F, Tzafriri AR, Petrini L, Pennati G. Investigating Balloon-Vessel Contact Pressure Patterns in Angioplasty: In Silico Insights for Drug-Coated Balloons. Drug-coated balloons have shown promising results as a minimally invasive approach to treat stenotic arteries, but recent animal studies have revealed limited, non-uniform coating transfer onto the arterial […]