JO Marx, J Lofgren, AL Miller, T Martin, D Eshar, T Trumble, M Williams-Fritze, J Smith, BD Pallas, L Krueger, A Blaney, C Pacharinsak. Laboratory Animal Medicine: Chapter 24 – Anesthesia, Analgesia, and Euthanasia Abstract: Anesthesia and analgesia are two of the most important tools in biomedical research. They enable veterinarians and researchers to perform […]
R Tzafriri, SA Parikh, ER Edelman. “Endovascular Drug Delivery from Stents and Balloons in Peripheral Arteries: What Every Interventionalist Must Know” READ FULL ARTICLE Synopsis: The effective and safe delivery of drugs to arterial targets via endovascular devices is governed by several key principles. These include the concepts of dissolution, diffusion and convection, drug binding […]
Safety and efficacy of flowable microfibrillar collagen hemostat in an ovine model of craniectomy with intraparenchymal defect compared to gelatin-thrombin hemostatic matrix. Darcy Gagne, Kasia Bradbury, Angela Bohnen, Kingsley Abode-Iyamah, Amie Rossi. Background: Flowable hemostatic agents offer advantages in confined surgical spaces, particularly in neurosurgery. However, data on microfibrillar collagen hemostats (MCH) in these applications […]
Hearing loss is a major global health challenge, affecting more than 1.5 billion people worldwide. While many medicines deliver life-changing benefits, more than 200 commonly used drugs can unintentionally cause ototoxicity, damage to the inner ear that may lead to lasting hearing problems. Ototoxicity can manifest in many ways: hearing loss, tinnitus (ringing in the […]
In drug development, the journey from bench to bedside is rarely a straight path. Many promising therapies deliver exceptional results in rodents, only to falter in human trials. These failures are costly, not just in terms of R&D budgets, but also in lost time and delayed access to potentially life-changing treatments for patients. The reason […]
by Ellie Khadir, DVM, PhD, Scientist & Study Director, CBSET and Lise Byelyayeva, MSc, Associate Director, Sales, Funding, & New Partnerships, Cilcare Hearing loss is a significant public health issue affecting over 466 million people globally. Hearing aids and cochlear implants fail to address the underlying causes. Gene therapy targets the fundamental genetic causes of […]
QP Pham, JV Groom II, C Sadasivan, DJ Fiorella, DC Madoff, L-J Guo, M Fornaciari, C Guertin, C Wiltsey, L Core, J Merlo, W Wustenberg, R Virmani, AS Arthur, RS Langer, GM Whitesides, U Sharma. An In Situ Curing, Shear-Responsive Biomaterial Designed for Durable Embolization of Microvasculature. Abstract: Endovascular embolization is a minimally-invasive technique whereby […]
DH Gagne, CC Steele, J Keating, K Bradbury, A Badhwar, SF Elahi. Preliminary Study of Yucatan Porcine Breast Morphology: Identifying Basic Differences and Similarities for Surgical Model Applications. Background/Objectives: The porcine mammary anatomy is poorly characterized, and structures are difficult to differentiate macroscopically, unlike human mammary tissue. The objective of this exploratory study was to […]
L Tscheuschner, E Stratakos, M Kostakis, M Gravanis, M Katsimpoulas, G Pennati, F Sigala, AR Tzafriri. Drug Loss at Arterial Bends Can Dominate Off-Target Drug Delivery by Paclitaxel-Coated Balloons. Background: Paclitaxel-coated balloons (PCBs) can deliver efficacious drug concentrations to treated arterial segments but are known to exhibit high tracking losses. We aimed to define the […]
Jessica L. Grimsby, Matthew D. Szkolnicki, Kevin A. Wood. Reevaluation of an Established In Vivo Gastric Vessel Bleed Model for Hemostatic Device Safety and Efficacy Testing This study was overseen by the CBSET Inc. Contract Research Organization’s (Lexington, MA, USA.) Institutional Animal Care and Use Committee (IACUC) and conformed to the “Guide for the Care […]