Seeherman, Howard J. PhD, VMD; Li, X. Jian MD; Wozney, John M. PhD. “Activation of Bone Remodeling Compartments in BMP-2-Injected Knees Supports a Local Vascular Mechanism for Arthritis-Related Bone Changes.” Summary: Synovial membrane-derived factors are implicated in arthritis-related bone changes. The route that synovial factors use to access subchondral bone and the mechanisms responsible for […]
Category Archives: Publications
Biomaterials: Balloon-based drug coating delivery to the artery wall is dictated by coating micro-morphology and angioplasty pressure gradients
Abraham R. Tzafriri, Benny Muraj, Fernando Garcia-Polite, Antonio G. Salazar-Martín, Peter Markham, Brett Zani, Anna Spognardi, Mazen Albaghdadi, Steve Alston, Elazer R. Edelman. “Balloon-based drug coating delivery to the artery wall is dictated by coating micro-morphology and angioplasty pressure gradients.” Summary: Paclitaxel coated balloon catheters (PCB) were developed as a polymer-free non-implantable alternative to drug […]
HEAR THIS! Potential Therapeutics for COVID-19 Should Be Tested for Auditory Safety
World Pharma Today, August 24, 2020 Authors: Wahid Awad, PhD, Chief Business Officer, CILcare and Michael Naimark, Director of Business Development, CBSET, Inc. As the COVID-19 pandemic continues to spread across the world, clinicians, academic institutions, private organizations, and governments are working tirelessly to find treatments to help patients and at-risk populations threatened by this […]
Annu Int Conf IEEE Eng Med Biol Soc: Design and implementation of in silico clinical trial for Bioresorbable Vascular Scaffolds
Georgia S Karanasiou, Panagiota I Tsobou, Nikolaos S Tachos, Luca Antonini, Lorenza Petrini, Giancarlo Pennati, Frank Gijsen, Farhad Rikhtegar Nezami, Rami Tzafriri, Ted Vaughan, Martin Fawdry, Dimitrios I Fotiadis. “Design and implementation of in silico clinical trial for Bioresorbable Vascular Scaffolds.” Summary: In the recent years, Bioresorbable Vascular Scaffolds (BVS) for the treatment of atherosclerosis […]
Circulation: Arrhythmia and Electrophysiology: Pulsed Field Ablation Using a Lattice Electrode for Focal Energy Delivery: Biophysical Characterization, Lesion Durability, and Safety Evaluation
Hagai Yavin, Ayelet Shapira-Daniels, Michael Barkagan, Jakub Sroubek, David Shim, Raffaele Melidone, Elad Anter. “Pulsed Field Ablation Using a Lattice Electrode for Focal Energy Delivery: Biophysical Characterization, Lesion Durability, and Safety Evaluation.” Summary: Pulsed field ablation (PFA) is a nonthermal energy that may provide safety advantages over radiofrequency ablation (RFA). One-shot PFA catheters have been developed […]
Circulation: Mortality and Paclitaxel-Coated Devices: An Individual Patient Data Meta-Analysis
Krishna J. Rocha-Sing , Sue Duval, Michael R. Jaff, Peter A. Schneider, Gary M. Ansel, Sean P. Lyden, Christopher M. Mullin, John P.A. Ioannidis, Sanjay Misra, Abraham R. Tzafriri, Elazer R. Edelman, Juan F. Granada, Christopher J. White, and Joshua A. Beckman. “Mortality and Paclitaxel-Coated Devices: An Individual Patient Data Meta-Analysis.” Summary: Paclitaxel-containing devices (PTXD) significantly […]
Biomedical Instrumentation & Technology: Analysis: Intravascular Devices with a Higher Risk of Polymer Emboli: The Need for Particulate Generation Testing
Chopra AM, Rapkiewicz A, Daggubati R, Sequeira A, Hu YC, Bhatt DL, Sharma SK, Cruz JP, Tzafriri AR, Edelman ER. “Analysis: Intravascular Devices with a Higher Risk of Polymer Emboli: The Need for Particulate Generation Testing.” Summary: Hydrophilic polymer coatings on intravascular devices lower friction between the device and vasculature, thereby reducing trauma during interventional procedures. […]
Journal of Neuerointerventional Surgery: Preclinical evaluation of the ANCD thrombectomy device: safety and efficacy in a swine clot model
Sanchez S, Bailey L, Ducore R, Andersson T, Nogueira R, Cognard C, Ribo M, Villanova H, Rios A, Galve I. “Preclinical evaluation of the ANCD thrombectomy device: safety and efficacy in a swine clot model” Summary: The Advanced Thrombectomy System (ANCD) provides a new funnel component designed to reduce clot fragmentation and facilitate retrieval in patients […]
Athrosc Sports Med Rehabil: Suture-Based Debris Behavior in the Draining Lymph Nodes of a Porcine Knee
Barber FA, Spenciner DB, Zani BG, Melidone R. “Suture-Based Debris Behavior in the Draining Lymph Nodes of a Porcine Knee: A Study of Silicone, Polyethylene and Carbon.” Purpose/Methods: To determine whether debris from a silicone core suture has an observable intra-articular or extra-articular impact or can be shown to migrate into the lymphatic system. Using […]
Journal of Controlled Release: Taking paclitaxel coated balloons to a higher level: Predicting coating dissolution kinetics, tissue retention and dosing dynamics
Abraham R.Tzafriri, Sahil A.Parikh, Elazer R.Edelman. “Taking paclitaxel coated balloons to a higher level: Predicting coating dissolution kinetics, tissue retention and dosing dynamics.” Summary: Paclitaxel coated balloons (PCBs) are a promising non-implantable alternative to drug-eluting stents, whereby drug is delivered to the arterial wall in solid form as a semi-continuous solid coating or as micro drug […]