Catheterization and Cardiovascular Interventions: Fracture in drug-eluting stents increases focal intimal hyperplasia in the atherosclerosed rabbit iliac artery

Conway C, Desany GJ, Bailey LR, Keating JH, Baker BL, Edelman ER. Fracture in drug-eluting stents increases focal intimal hyperplasia in the atherosclerosed rabbit iliac artery. Summary: Controlled release of therapeutic agents, such as sirolimus and its analogs, or paclitaxel, has reduced tissue-based drug-eluting stent failure modes compared to bare metal stents. In the stent, restenosis […]

International Journal of Toxicology: Percutaneous Hepatic Perfusion With Filtered Melphalan for Localized Treatment of Metastatic Hepatic Disease: A Risk Assessment

Pauline E McEwan, Lynn Bailey, David Trost, Christopher Scull, John H Keating, Misty Williams, Robert J Guttendorf. Percutaneous Hepatic Perfusion With Filtered Melphalan for Localized Treatment of Metastatic Hepatic Disease: A Risk Assessment. Summary: Regional therapies for metastatic liver disease have garnered interest in recent years due to technological advances in drug delivery. A percutaneous […]

Biomaterials Forum: Stem cell therapies for peripheral arterial disease: clinical status, promising biomaterials strategies and tips for successful translation

Ngan F. Huang, Michael Naimark, Rami Tzafriri. “Stem cell therapies for peripheral arterial disease: clinical status, promising biomaterials strategies and tips for successful translation” Summary: Cell transplantation into the ischemic tissue is being studied as a therapeutic strategy to re-establish functional collateral networks that supply oxygenated blood and preserve tissue viability. While the clinical picture is evolving, […]

Cardiovascular Revascularization Medicine: Anatomical and procedural determinants of ambulatory blood pressure lowering following catheter-based renal denervation using radiofrequency

Lauder L, Ewen S, Tzafriri AR, Edelman ER, Cremers B, Kulenthiran S, Ukena C, Linz D, Kindermann I, Tsioufis C, Scheller B, Böhm M, Mahfoud F. Anatomical and procedural determinants of ambulatory blood pressure lowering following catheter-based renal denervation using radiofrequency. Summary: Because little is known of the impact of renal anatomy and procedural parameters […]

The International Journal of Cardiology Imaging: Vessel centerline reconstruction from non-isocentric and non-orthogonal paired monoplane angiographic images

Mie Kunio, Caroline C. O’Brien, Augusto C. Lopes Jr., Lynn Bailey, Pedro A. Lemos, Guillermo J. Tearney, Elazer R. Edelman. Vessel centerline reconstruction from non-isocentric and non-orthogonal paired monoplane angiographic images. Summary: Three-dimensional reconstruction of a vessel centerline from paired planar coronary angiographic images is critical to reconstruct the complex three-dimensional structure of the coronary artery lumen […]

Respirology: Pharmacokinetics and safety of paclitaxel delivery into porcine airway walls by a new endobronchial drug delivery catheter

Tsukada H, Entcheva-Dimitrov P, Ernst A, Rafeq S, Keating JH, Seward KP, Yarmus L. Pharmacokinetics and safety of paclitaxel delivery into porcine airway walls by a new endobronchial drug delivery catheter. Background and objective: Intratumoral administration of chemotherapeutic agents is a treatment modality that has proven efficacious in reducing the recurrence of tumours and increases specificity […]

World Pharma Today: Stem Cell and Regenerative Therapies for Hearing Loss

by Michael Naimark, Director of Business Development, CBSET, Inc. and Marie-Pierre Pasdelou, PharmD, founder and the Chief Development Officer, CILcare The year 2018 marks a notable milestone in the history of stem cells and regenerative medicine. In the last 20 years new technologies such as induced pluripotent stem cell lines (iPSCs) and CRISPR/Cas9 editing are […]

Journal of Controlled Release: Defining drug and target protein distributions after stent-based drug release: Durable versus deployable coatings

Tzafriri AR, Garcia-Polite F, Li X, Keating J, Balaguer JM, Zani B, Bailey L, Markham P, Kiorpes TC, Carlyle W, Edelman ER. Defining drug and target protein distributions after stent-based drug release: Durable versus deployable coatings. Summary: Innovations in drug eluting stent designs make it increasingly important to develop models for differentiating performance through spatial […]