Methe H, Nanasato M, Spognardi AM, Groothuis A, Edelman ER. . T-helper 2 cells are essential for modulation of vascular repair by allogeneic endothelial cells. Summary: Endothelial cells (EC) embedded within three-dimensional matrices (MEEC) when placed in the vascular adventitia control lumenal inflammation and intimal hyperplasia. Matrix-embedding alters endothelial immunogenicity in vitro. T helper (Th) driven […]
Category Archives: Publications
Journal of Controlled Release: Lesion complexity determines arterial drug distribution after local drug delivery
Tzafriri A, Vukmirovic N, Kolachalama V, Astafieve I, Edelman ER. Lesion complexity determines arterial drug distribution after local drug delivery. Summary: Though stents are deployed in diseased arteries drug distribution has only been quantified in intact, non-diseased vessels. We correlated steady-state arterial drug distribution with tissue ultrastructure and composition in abdominal aortae from atherosclerotic human autopsy […]
PloS ONE: Luminal flow amplifies stent-based drug deposition in arterial bifurcations
Kolachalama VB, Levine EG, Edelman ER. Luminal flow amplifies stent-based drug deposition in arterial bifurcations. Summary: Treatment of arterial bifurcation lesions using drug-eluting stents (DES) is now common clinical practice and yet the mechanisms governing drug distribution in these complex morphologies are incompletely understood. It is still not evident how to efficiently determine the efficacy of […]
Circulation: Vascular regeneration by local growth factor release is self-limited by microvascular clearance
Le KN, Hwang CW, Tzafriri A, Lovich MA, Hayward A, Edelman ER. Vascular regeneration by local growth factor release is self-limited by microvascular clearance. Summary: The challenge of angiogenesis science is that stable sustained vascular regeneration in humans has not been realized despite promising preclinical findings. We hypothesized that angiogenic therapies powerfully self-regulate by dynamically altering […]
Journal of Controlled Release: Intramuscular drug transport under mechanical loading: resonance between tissue function and uptake
Wu, P.I., S. Minisini, and E.R. Edelman. Intramuscular drug transport under mechanical loading: resonance between tissue function and uptake. Summary: Dynamic architecture and motion in mechanically active target tissues can influence the pharmacokinetics of locally delivered agents. Drug transport in skeletal muscle under controlled mechanical loads was investigated. Static (0-20%) and cyclic (+/-2.5% amplitude, 0-20% mean, […]
Cell Proliferation: Diffusion-limited binding explains binary dose response for local arterial and tumor drug delivery
Tzafriri AR, Levin AD, Edelman ER. Diffusion-limited binding explains binary dose response for local arterial and tumor drug delivery. Summary: Local drug delivery has transformed medicine, yet it remains unclear how drug efficacy depends on physicochemical properties and delivery kinetics. Most therapies seek to prolong release, yet recent studies demonstrate sustained clinical benefit following local bolus […]
Circulation Research: Heparanase alters arterial structure, mechanics, and repair following endovascular stenting in mice
Baker AB, Groothuis A, Jonas M, Ettenson DS, Shazly T, Zcharia E, Vlodavsky I, Seifert P, Edelman ER. Heparanase alters arterial structure, mechanics, and repair following endovascular stenting in mice. Summary: Heparan sulfate proteoglycans (HSPGs) are potent regulators of vascular remodeling and repair. Heparanase is the major enzyme capable of degrading heparan sulfate in mammalian cells. Here […]
Journal of Controlled Release: Luminal flow patterns dictate arterial drug deposition in stent-based delivery
Kolachalama VB, Tzafriri AR, Arifin DY, Edelman ER. Luminal flow patterns dictate arterial drug deposition in stent-based delivery. Summary: Endovascular stents reside in a dynamic flow environment and yet the impact of flow on arterial drug deposition after stent-based delivery is only now emerging. We employed computational fluid dynamic modeling tools to investigate the influence of […]
Journal of Controlled Release: Thrombus causes fluctuations in arterial drug delivery from intravascular stents
Balakrishnan B, Dooley J, Kopia G, Edelman ER. Thrombus causes fluctuations in arterial drug delivery from intravascular stents. Summary: Arterial drug concentrations determine local toxicity. As such the emergent safety concerns surrounding drug-eluting stents mandate an investigation of the factors contributing to fluctuations in arterial drug uptake. Drug-eluting stents were implanted into porcine coronary arteries,arterial drug […]
Cell Prolif: Phospholipase C-delta extends intercellular signalling range and responses to injury-released growth factors in non-excitable cells
Mi, L.Y., D.S. Ettenson, and E.R. Edelman. Phospholipase C-delta extends intercellular signalling range and responses to injury-released growth factors in non-excitable cells. Summary: Intercellular communication in non-excitable cells is restricted to a limited range close to the signal source. Here, we have examined whether modification of the intracellular microenvironment could prolong the spatial proposition of […]