Journal of Invasive Cardiology: Serial Evaluation of Vascular Response After Implantation of a New Sirolimus-Eluting Stent With Bioabsorbable Polymer (MISTENT): an optical coherence tomography and histopathological study.

Attizzani GF, Bezerra HG, Chamié D, Fujino Y, Spognardi AM, Stanley JR, Yamamoto H, Mehanna E, Wang W, Carlyle WC, McClain JB, Costa MA. Serial Evaluation of Vascular Response After Implantation of a New Sirolimus-Eluting Stent With Bioabsorbable Polymer (MISTENT): an optical coherence tomography and histopathological study. Summary: Novel vascular scaffolds aim at equipoise between safety […]

Langmuir: Natural Tissue Microenvironmental Conditions Modulate Adhesive Material Performance

Nuria Oliva, Sagi Shitreet, Eytan Abraham, Butch Stanley, Elazer R. Edelman, and Natalie Artzi. Natural Tissue Microenvironmental Conditions Modulate Adhesive Material Performance. Summary: We designed and optimized tissue-responsive adhesive materials by matching material and tissue properties. A two-component material based on dextran aldehyde and dendrimer amine provides a cohesive gel through aldehyde–amine cross-linking and an adhesive […]

Journal of Controlled Release: Enhanced Drug Delivery Capabilities from Stents Coated with Absorbable Polymer and Crystalline Drug

Carlyle WC, McClain JB, Tzafriri AR, Bailey L, Zani BG, Markham PM, Stanley JR, Edelman ER. Enhanced Drug Delivery Capabilities from Stents Coated with Absorbable Polymer and Crystalline Drug. Summary: Current drug eluting stent (DES) technology is not optimized with regard to the pharmacokinetics of drug delivery. A novel, absorbable-coating sirolimus-eluting stent (AC-SES) was evaluated for […]

Journal of Controlled Release: Stent elution rate determines drug deposition and receptor-mediated effects

Tzafriri AR, Groothuis A, Price GS, Edelman ER. Stent elution rate determines drug deposition and receptor-mediated effects. Summary: Drug eluting stent designs abound and yet the dependence of efficacy on drug dose and elution duration remains unclear. We examined these issues within a mathematical framework of arterial drug distribution and receptor binding following stent elution. […]

EuroIntervention: Angiographic and Histological Results Following Implantation of a Novel Stent-On-A-Wire in the Animal Model

Diletti R, Garcia-Garcia HM, van Geuns RJ, Farooq V, Bailey L, Rousselle S, Kopia G, Easterbrook W, Pomeranz M, Serruys P. Angiographic and Histological Results Following Implantation of a Novel Stent-On-A-Wire in the Animal Model. Summary: The Svelte Stent-On-A-Wire (SOAW) is a thin strut novel device consisting of a balloon-expandable cobalt-chromium stent premounted onto a single […]

Ann NY Acad Sci: Engineered arterial models to correlate blood flow to tissue biological response

Martorell J, Santoma P, Molins JJ, Garcia-Granada AA, Bea JA, Edelman ER, and Balcells M. Engineered arterial models to correlate blood flow to tissue biological response. Summary: This paper reviews how biomedical engineers, in collaboration with physicians, biologists, chemists, physicists, and mathematicians, have developed models to explain how the impact of vascular interventions on blood flow […]

Circulation: Stent thrombogenicity early in high-risk interventional settings is driven by stent design and deployment and protected by polymer-drug coatings.

Kolandaivelu, K., et al. Stent thrombogenicity early in high-risk interventional settings is driven by stent design and deployment and protected by polymer-drug coatings. Summary: Contrary to popular perception, drug/polymer coatings do not inherently increase acute stent clotting; they reduce thrombosis. However, strut dimensions and positioning relative to the vessel wall are critical factors in modulating stent […]