CBSET's approach to the study of novel CAD therapies
CBSET was founded with a strong core competence in coronary artery disease (CAD) models for the evaluation of interventional endovascular therapies and has continued to support innovation in this field. CBSET's scientists have published on novel models and imaging methods for evaluating CAD treatments, as well as immunohistochemistry and computational models for technology differentiation and optimization.
This excellence was recognized and partially supported by a European Union Horizon 2020 research and innovation program.
Scientific papers/presentations related to CAD therapies:
Fracture in drug-eluting stents increases focal intimal hyperplasia in the atherosclerosed rabbit iliac artery. Conway C, Desany GJ, Bailey LR et al. Catheter Cardiovasc Interv. 2019 Feb 1;93(2):278-285. doi: 10.1002/ccd.27726.
Defining drug and target protein distributions after stent-based drug release: Durable versus deployable coatings. Tzafriri AR, Garcia-Polite F, Li X et al. J Control Release. 2018 Mar 28;274:102-108.
Tracking tissue distribution and retention of Sirolimus and analog delivered from polymer free drug coated stents. Tzafriri AR, Rotllant-Daurella L, Keating JH et al. TCT-508 JACC. 2018, 72 (13, Supplement) Page B204.
Local, regional, and systemic factors in BRS thrombosis in small vessels: understanding the sub-2.5mm barrier. Kolandaivelu K, Maria Balaguer J, Gracia MT et al. EuroPCR; 2018 May 21-24; Paris, France.
Sirolimus analog lipophilicity dictates release kinetics and tissue retention after implantation of polymer free drug coated stents. Tzafriri AR, Bailey L, Keating J, Markham P et al. EuroPCR; 2017 May 16-19; Paris, France.
Vessel centerline reconstruction from non-isocentric and non-orthogonal paired monoplane angiographic images. Mie Kunio, Caroline C. O’Brien, Augusto C. Lopes Jr. et al. Int J Cardiovasc Imaging May 2018, Volume 34, Issue 5, pp 673–682. doi.org/10.1007/s10554-017-1275-z14.
Sex differences in the outcomes of stent implantation in mini-swine model. Kunio M, Wong G, Markham PM, Edelman ER. PLoS One. 2018 Jan 29;13(1):e0192004. doi: 10.1371/journal.pone.0192004. eCollection 2018.
Randomized Comparison of Ridaforolimus- and Zotarolimus-Eluting Coronary Stents in Patients With Coronary Artery Disease: Primary Results From the BIONICS Trial (BioNIR Ridaforolimus-Eluting Coronary Stent System in Coronary Stenosis). Kandzari DE, Smits PC, Love MP et al. Circulation. 2017 Oct 3;136(14):1304-1314. doi: 10.1161/CIRCULATIONAHA.117.028885.
Lost in translational filters between peers. Kolandaivelu K, Tzafriri AR. EuroIntervention. 2017 Dec 8; Volume 13 Number 12.
Ultra-hydrophilic stent platforms promote early vascular healing and minimise late tissue response: a potential alternative to second-generation drug-eluting stents. Kolandaivelu K, Bailey L, Buzzi S et al. EuroIntervention. 2017 Apr 20;12(17):2148-2156.
Stents: Biomechanics, Biomaterials, and Insights from Computational Modeling. Karanasiou GS, Papafaklis MI, Conway C, Michalis LK, Tzafriri R, Edelman ER. Fotiadis DI. Ann Biomed Eng. 2017 Apr;45(4):853-872.
Pathology of Endovascular Stents. K Nakamura, MD; JH Keating, DVM; ER Edelman, MD, PhD. Interv Cardiol Clin. 2016 Jul;5(3):307-320.
Endovascular Drug Delivery and Drug Elution Systems: First Principles. Tzafriri AR, Edelman ER. Interv Cardiol Clin. 2016 Jul;5(3):391-403.
Ridaforolimus Eluting Stents with Customizable Diffusion Controlled Release Kinetics and Tissue Uptake. Tzafriri AR, Markham PM, LaRochelle AW et al. CRT-500.10 JACC Cardiol Intv. 2016;9(4_S):S56. doi:10.1016/j.jcin.2015.12.219.
Sustained Efficacy and Arterial Drug Retention by a Fast Drug Eluting Cross-Linked Fatty Acid Coronary Stent Coating. Artzi N, Tzafriri AR, Faucher KM et al. Ann Biomed Eng. 2016 Jul;44(7):2251-60. doi: 10.1007/s10439-015-1518-x.
Computational modeling of local stent pharmacokinetics: Replacement, Reduction Refinement, and Return on Investment. Tzafriri AR, Markham P. MDIC Modeling and Simulation Summit, Washington DC, 2014.
Computational Modeling Accurately Predicts In Vivo Arterial Elimination of Sirolimus-Analog Eluting Stents. Tzafriri AR, Markham PM, LaRochelle AW et al. FDA- ASME Frontiers in Medical Devices meeting, University College, MD, 2013.
Serial Evaluation of Vascular Response After Implantation of a New Sirolimus-Eluting Stent With Bioabsorbable Polymer (MISTENT): an optical coherence tomography and histopathological study. Attizzani GF, Bezerra HG, Chamié D et al. Journal of Invasive Cardiology, 2012 Nov;24(11):560-8.
Enhanced Drug Delivery Capabilities from Stents Coated with Absorbable Polymer and Crystalline Drug. Carlyle, WC, McClain, JB, Tzafriri, AR et al. Journal of Controlled Release. 162(3):561-567.
Stent Elution Rate Determines Drug Deposition and Receptor-Mediated Effects. Tzafriri, AR, Groothuis, A, Price, S, Edelman, ER. Journal of Controlled Release. 2012, 161(3):918-926.
Systemic and Local Tissue Pharmacokinetics of Single and Overlapping NEVOTM Sirolimus Eluting Stents in the Porcine Coronary Artery Model. Tzafriri, AR, Sun YP, Price S, Rogers, C. TCT-433 , JACC 2011;58(20s1):B120-B121.
Stent thrombogenicity early in high-risk interventional settings is driven by stent design and deployment and protected by polymer-drug coatings. Kolandaivelu K, Swaminathan R, Gibson WJ et al. Circulation, 2011. 123(13): p. 1400-9.
A Comprehensive Analysis of DES and Bare Metal Stents Using Morphometric SEM Images of Overlapping Stent Pairs in a Rabbit Iliac Model to Assess Overall Healing. Groothius A, Seifert P, Wong G et al. Transcatheter Cardiovascular Therapeutics, Washington, DC, 2010.
Computational Model Predicts Multi-Phasic Drug Elution Kinetics From Bulk Degrading Inlays in Stent Reservoirs. Tzafriri AR, Groothuis A, Edelman ER. FDA/NHLBI/NSF Workshop on Computer Methods for Cardiovascular Devices, Bethesda, MD, 2010.
Scientific papers/presentations related to InSilc:
An in silico trials platform for the evaluation of effect of the arterial anatomy configuration on stent implantation. Georgia S Karanasiou, Panagiota I Tsompou, Nikolaos Tachos et al. Annual International Conference of the IEEE Engineering in Medicine & Biology Society: 2021 Nov;2021:4213-4217. doi: 10.1109/EMBC46164.2021.9629950.
Computational Prediction Of Drug-eluting Stent Performance In Patient-specific Arteries – A Virtual Reality. Tzafriri AR, Rikhtegar Nezami F, Edelman ER. JACC: Cardiovascular Interventions, Volume 13, Issue 4, Supplement, 24 February 2020, Pages S43-S44.
Design and implementation of in silico clinical trial for Bioresorbable Vascular Scaffolds. Karanasiou GS, Tsobou PI, Tachos NS et al. Annu Int Conf IEEE Eng Med Biol Soc. 2020 Jul;2020:2675-2678.
Press Release: Preclinical safety studies demonstrate that drug presence can accentuate pathological responses at stent fracture sites
Press Release: Study Validates New Approach for Optimizing Endovascular Drug Delivery Using Stents with a Deployable Coating That Enhances Sirolimus Distribution Compared to Traditional DES
Press Release: Preclinical safety studies must include equally balanced male/female animal models to shed light on sex-dependent vascular responses in humans
News Advisory: You Need To Know: Endovascular Drug Delivery Is Experiencing a Resurgence in Innovation
Press Release: Data provides new insights into the optimal balance between drug-eluting stent coating material properties and drug elution kinetics
Press Release: CBSET expands capabilities for high-speed, high-resolution 3D image-guided interventions in the preclinical development of cardiovascular therapies