FOCUS ON DRUG-COATED BALLOONS

FOCUS ON DRUG-COATED BALLOONS

HIGHLIGHT 
Congratulations to Efstathios Stratakos, PhD the recipient of a 2025 Athanasieu ABME Student and Post-Doc Paper Award from The Annals of Biomedical Engineering (ABME) for the paper:

A Novel In Silico–Ex Vivo Model for Correlating Coating Transfer to Tissue with Local Drug-Coated Balloon-Vessel Contact Pressures. E Stratakos, L Tscheuschner, L Vincenzi, E Pedrinazzi, F Sigala, L D’Andrea, D Gastaldi, F Berti, A R Tzafriri, G Pennati.

Annals of Biomedical Engineering, 12 Dec 2024

 

CBSET, committed to the development of novel experimental and computational models for drug-coated balloon therapies

CBSET has developed novel experimental and computational models that define the barrier effects of tissue components on drugs of interest. CBSET's scientists have published a range of data and analyses on drug-coated balloon therapies.

Scientific papers/presentations on drug-coated balloon therapies:

Mechanistic Kinetic Modeling Of Polymer Bioresorption Can Derisk The Preclinical Safety Evaluation Of Bioresorbable Polymer Coated Stents. AR Tzafriri, A-M Spognardi, P Markham, JH Keating, MW Kayo, S Karamdoust, A Pollit,  A Raval, R Mandal. Presented at Cardiovascular Research Technologies (CRT), 2026 March 7-10, Washington DC.

Stenosis Limited Local Paclitaxel Release and Arterial Delivery From Paclitaxel Coated Balloons in a Porcine Peripheral Instent Restenosis Model. AR Tzafriri, A-M Spognardi, J Budrewicz, B Muraj, P Markham. JACC Int. 2026 Vol. 19 No. 5_Supplement 300.14. Presented at Cardiovascular Research Technologies (CRT), 2026 March 7-10, Washington DC.

Drug Loss at Arterial Bends Can Dominate Off-Target Drug Delivery by Paclitaxel-Coated Balloons. L Tscheuschner, E Stratakos, M Kostakis, M Gravanis, M Katsimpoulas, G Pennati, F Sigala, AR Tzafriri. Pharmaceutics 2025, 17(2), 197.

A Novel In Silico–Ex Vivo Model for Correlating Coating Transfer to Tissue with Local Drug-Coated Balloon-Vessel Contact Pressures. E Stratakos, L Tscheuschner, L Vincenzi, E Pedrinazzi, F Sigala, L D’Andrea, D Gastaldi, F Berti, A R Tzafriri, G Pennati. Ann Biomed Eng (2024). doi: 10.1007/s10439-024-03634-6.

Modeling of drug-coated balloon inflation correlates drug transfer with vessel geometry and balloon design. Efstathios Stratakos, Rami Tzafriri, Benny Muraj, Jay Budrewicz, Anna Maria Spognardi, Linnea Tscheuschner, Fragiska Sigala, Lorenza Petrini, Giancarlo Pennati. Presentation at the 29th Congress of the European Society of Biomechanics, June 30-July 3, 2024, Edinburgh, Scotland.

Visualization and Quantification of Acute Drug Coating Distribution on Porcine Esophagus and Common Bile Duct Surfaces After Drug Coated Balloon Treatments. Budrewicz, B. Muraj, P. Markham, R. Tzafriri. Presentation at Digestive Disease Week (DDW), May 21, 2024.


Investigating Balloon-Vessel Contact Pressure Patterns in Angioplasty: In Silico Insights for Drug-Coated Balloons. Stratakos E, Antonini L, Poletti G, Berti F, Tzafriri AR, Petrini L, Pennati G. Ann Biomed Eng. 2023 Sep 26. doi: 10.1007/s10439-023-03359-y. Epub ahead of print. PMID: 37751027.

Directional atherectomy before paclitaxel coated balloon angioplasty in complex femoropopliteal disease: The VIVA REALITY study. KJ Rocha-Sing, R Sachar, BG DeRubertis, CCA Nolte-Ernsting, JG Winscott, P Krishnan, EC Scott, LA Garcia, J-L Baeriswyl, G Ansel, K Rosenfield, T Zeller. Catheter Cardiovasc Interv. 2021 Sep;98(3):549-558. doi: 10.1002/ccd.29777.

linc 2021 Lesion ModificationLesion Modification with a Micro-Incision Vessel Preparation System Enhances Balloon-Based Drug Delivery in Complex Porcine Restenotic Lesions. Rami Tzafriri, Jay Budrewicz, Lynn Bailey, Peter Markham et al. Presented at LINC 2021, January 25, 2021.

Balloon-based drug coating delivery to the artery wall is dictated by coating micro-morphology and angioplasty pressure gradients Abraham R. Tzafriri, Benny Muraj, Fernando Garcia-Polite et al. Biomaterials. 2020 Nov;260:120337.

Six Month Safety Evaluation Of The Chocolate Touch™ Drug-coated Balloon Catheter In The Swine Peripheral Artery Model. Abraham R. Tzafriri, Anna Maria Spognardi, LynnBailey, John Keating, Peter Markham, Gary Binyamin, Maria Pizarro, Eitan Konstantino, Elazer R. Edelman. JACC: Cardiovascular Interventions Volume 13, Issue 4, Supplement, 24 February 2020, Pages S31-S32.

Taking paclitaxel coated balloons to a higher level: Predicting coating dissolution kinetics, tissue retention and dosing dynamics. Abraham R.Tzafriri, Sahil A. Parikh, Elazer R. Edelman. Journal of Controlled Release. Volume 310, 28 September 2019, Pages 94-102.

charingcrosscoatedballoonsEvaluation of a novel paclitaxel coated intravascular balloon. Abraham R. Tzafriri, PhD. Presented at CX 2017 – The Charing Cross International Symposium, April 25-28, Kensington, London, UK.

Mechanisms Underlying Drug Delivery to Peripheral Arteries. Li J, Tzafriri R, Patel SM, Parikh SA. Interventional Cardiology Clinics. 2017 Apr;6(2):197-216. doi: 10.1016/j.iccl.2016.12.004.

Multiple drug coated balloon exposures increase arterial permeability and drug retention. Rami Tzafriri; Peter Markham; Brett Zani; Steve Alston; Elazer Edelman. Presented at: Innovations in Cardiovascular Interventions (ICI), Dec 4-6, 2016, Tel Aviv, Israel.

Mechanisms of Tissue Uptake and Retention in Zotarolimus-Coated Balloon Therapy. Vijaya B. Kolachalama, Stephen D. Pacetti, Joseph W. Franses et al. Circulation. 2013;127:2047-2055.

Drug-coated Balloon News:

CBSET, training the next generation of researchers:

CBSET is leveraging its expertise in animal computational models and drug-coated balloon therapies to support its medical device industry sponsors and to train the next generation of physicians and scientist working in this field. These missions have been recognized and are partially supported by DECODE, a European Union Horizon 2020 / Marie Curie training grant.

The project leading to this application has received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No 956470.