Tzafriri AR, Mahfoud F, Keating JH, Markham PM, Spognardi A, Wong G, Fuimaono K, Böhm M, Edelman ER. Innervation patterns may limit response to endovascular renal denervation. Summary: The purpose of this study was to correlate response to endovascular radiofrequency ablation of renal arteries with nerve and ganglia distributions. We examined how renal neural network anatomy affected […]
Category Archives: Publications
JACC Cardiovasc Interv: Methodological Standardization for the Pre-Clinical Evaluation of Renal Sympathetic Denervation
Sakakura K, Ladich E, Edelman ER, Markham P, Stanley JR, Keating J, Kolodgie FD, Virmani R, Joner M..Methodological Standardization for the Pre-Clinical Evaluation of Renal Sympathetic Denervation. Summary: Transcatheter ablation of renal autonomic nerves is a viable option for the treatment of resistant arterial hypertension; however, structured pre-clinical evaluation with standardization of analytical procedures remains a […]
Cardiovascular Research: Extent of flow recirculation governs expression of atherosclerotic and thrombotic biomarkers in arterial bifurcations
Martorell, Santomá, Kolandaivelu, Kolachalama, Melgar-Lesmes, Molins, García, Edelman, Balcells. Extent of flow recirculation governs expression of atherosclerotic and thrombotic biomarkers in arterial bifurcations. Summary: Atherogenesis, evolution of plaque, and outcomes following endovascular intervention depend heavily on the unique vascular architecture of each individual. Patient-specific, multiscale models able to correlate changes in microscopic cellular responses with relevant […]
J Hypertens: Evaluation of renal nerve morphological changes and norepinephrine levels following treatment with novel bipolar radiofrequency delivery systems in a porcine model.
Cohen-Mazor M, Mathur P, Stanley JR, Mendelsohn FO, Lee H, Baird R, Zani BG, Markham PM, Rocha-Singh K. Evaluation of renal nerve morphological changes and norepinephrine levels following treatment with novel bipolar radiofrequency delivery systems in a porcine model. Summary: A porcine model (N = 46) was used to investigate renal norepinephrine levels and changes to renal artery […]
Vascular: Preclinical evaluation of the InCraft® aortic endograft in a sheep model.
Teigen C, Stanley JR, Johnsont P, Gross C. Preclinical evaluation of the InCraft® aortic endograft in a sheep model. Summary: Animal models remain the gold standard for the preclinical evaluation of tissue response, sealing and integrity of aortic endografts. Preclinical testing of the InCraft® device was performed to evaluate these attributes. Through the femoral arteries of eight […]
Biomaterials Forum: Computational Modeling of Biomaterial Degradation and Local Drug Release Facilitates Rapid Device Development, Enhanced Performance & Regulatory Evaluation
Tzafriri, AR, Artzi, N. Computational Modeling of Biomaterial Degradation and Local Drug Release Facilitates Rapid Device Development, Enhanced Performance & Regulatory Evaluation. Summary: Biodegradable materials are popular platforms for biocompatible and tunable local drug release. However, controlling and predicting material degradation dynamics, and the associated drug release kinetics in the complex in vivo environment often proves […]
Circulation: Mechanisms of Tissue Uptake and Retention in Zotarolimus-Coated Balloon Therapy
Vijaya B. Kolachalama, Stephen D. Pacetti, Joseph W. Franses, John J. Stankus, Hugh Q. Zhao, Tarek Shazly, Alexander Nikanorov, Lewis B. Schwartz, Abraham R. Tzafriri, Elazer R. Edelman. Mechanisms of Tissue Uptake and Retention in Zotarolimus-Coated Balloon Therapy Summary:Drug-coated balloons are increasingly used for peripheral vascular disease, and, yet, mechanisms of tissue uptake and retention […]
Journal of Histotechnology: Correlative evaluation of variable pressure-scanning electron microscopy to histology methods for vascular tissues.
P. Seifert, K. Regan, B.G. Zani, G. Wong, and J. Stanley. Correlative evaluation of variable pressure-scanning electron microscopy to histology methods for vascular tissues. Journal of Histotechnology, 2013 March; 36 (1): 25-29.
Journal of Invasive Cardiology: Serial Evaluation of Vascular Response After Implantation of a New Sirolimus-Eluting Stent With Bioabsorbable Polymer (MISTENT): an optical coherence tomography and histopathological study.
Attizzani GF, Bezerra HG, Chamié D, Fujino Y, Spognardi AM, Stanley JR, Yamamoto H, Mehanna E, Wang W, Carlyle WC, McClain JB, Costa MA. Serial Evaluation of Vascular Response After Implantation of a New Sirolimus-Eluting Stent With Bioabsorbable Polymer (MISTENT): an optical coherence tomography and histopathological study. Summary: Novel vascular scaffolds aim at equipoise between safety […]
Langmuir: Natural Tissue Microenvironmental Conditions Modulate Adhesive Material Performance
Nuria Oliva, Sagi Shitreet, Eytan Abraham, Butch Stanley, Elazer R. Edelman, and Natalie Artzi. Natural Tissue Microenvironmental Conditions Modulate Adhesive Material Performance. Summary: We designed and optimized tissue-responsive adhesive materials by matching material and tissue properties. A two-component material based on dextran aldehyde and dendrimer amine provides a cohesive gel through aldehyde–amine cross-linking and an adhesive […]