J Hypertens: Evaluation of renal nerve morphological changes and norepinephrine levels following treatment with novel bipolar radiofrequency delivery systems in a porcine model.

Cohen-Mazor M, Mathur P, Stanley JR, Mendelsohn FO, Lee H, Baird R, Zani BG, Markham PM, Rocha-Singh K. Evaluation of renal nerve morphological changes and norepinephrine levels following treatment with novel bipolar radiofrequency delivery systems in a porcine model. Summary: A porcine model (N = 46) was used to investigate renal norepinephrine levels and changes to renal artery […]

Vascular: Preclinical evaluation of the InCraft® aortic endograft in a sheep model.

Teigen C, Stanley JR, Johnsont P, Gross C. Preclinical evaluation of the InCraft® aortic endograft in a sheep model. Summary: Animal models remain the gold standard for the preclinical evaluation of tissue response, sealing and integrity of aortic endografts. Preclinical testing of the InCraft® device was performed to evaluate these attributes. Through the femoral arteries of eight […]

Biomaterials Forum: Computational Modeling of Biomaterial Degradation and Local Drug Release Facilitates Rapid Device Development, Enhanced Performance & Regulatory Evaluation

Tzafriri, AR, Artzi, N. Computational Modeling of Biomaterial Degradation and Local Drug Release Facilitates Rapid Device Development, Enhanced Performance & Regulatory Evaluation. Summary: Biodegradable materials are popular platforms for biocompatible and tunable local drug release. However, controlling and predicting material degradation dynamics, and the associated drug release kinetics in the complex in vivo environment often proves […]

Circulation: Mechanisms of Tissue Uptake and Retention in Zotarolimus-Coated Balloon Therapy

Vijaya B. Kolachalama, Stephen D. Pacetti, Joseph W. Franses, John J. Stankus, Hugh Q. Zhao, Tarek Shazly, Alexander Nikanorov, Lewis B. Schwartz, Abraham R. Tzafriri, Elazer R. Edelman. Mechanisms of Tissue Uptake and Retention in Zotarolimus-Coated Balloon Therapy Summary:Drug-coated balloons are increasingly used for peripheral vascular disease, and, yet, mechanisms of tissue uptake and retention […]

Journal of Histotechnology: Correlative evaluation of variable pressure-scanning electron microscopy to histology methods for vascular tissues.

P. Seifert, K. Regan, B.G. Zani, G. Wong, and J. Stanley. Correlative evaluation of variable pressure-scanning electron microscopy to histology methods for vascular tissues. Journal of Histotechnology, 2013 March; 36 (1): 25-29.

Journal of Invasive Cardiology: Serial Evaluation of Vascular Response After Implantation of a New Sirolimus-Eluting Stent With Bioabsorbable Polymer (MISTENT): an optical coherence tomography and histopathological study.

Attizzani GF, Bezerra HG, Chamié D, Fujino Y, Spognardi AM, Stanley JR, Yamamoto H, Mehanna E, Wang W, Carlyle WC, McClain JB, Costa MA. Serial Evaluation of Vascular Response After Implantation of a New Sirolimus-Eluting Stent With Bioabsorbable Polymer (MISTENT): an optical coherence tomography and histopathological study. Summary: Novel vascular scaffolds aim at equipoise between safety […]

Langmuir: Natural Tissue Microenvironmental Conditions Modulate Adhesive Material Performance

Nuria Oliva, Sagi Shitreet, Eytan Abraham, Butch Stanley, Elazer R. Edelman, and Natalie Artzi. Natural Tissue Microenvironmental Conditions Modulate Adhesive Material Performance. Summary: We designed and optimized tissue-responsive adhesive materials by matching material and tissue properties. A two-component material based on dextran aldehyde and dendrimer amine provides a cohesive gel through aldehyde–amine cross-linking and an adhesive […]

Journal of Controlled Release: Enhanced Drug Delivery Capabilities from Stents Coated with Absorbable Polymer and Crystalline Drug

Carlyle WC, McClain JB, Tzafriri AR, Bailey L, Zani BG, Markham PM, Stanley JR, Edelman ER. Enhanced Drug Delivery Capabilities from Stents Coated with Absorbable Polymer and Crystalline Drug. Summary: Current drug eluting stent (DES) technology is not optimized with regard to the pharmacokinetics of drug delivery. A novel, absorbable-coating sirolimus-eluting stent (AC-SES) was evaluated for […]

Journal of Controlled Release: Stent elution rate determines drug deposition and receptor-mediated effects

Tzafriri AR, Groothuis A, Price GS, Edelman ER. Stent elution rate determines drug deposition and receptor-mediated effects. Summary: Drug eluting stent designs abound and yet the dependence of efficacy on drug dose and elution duration remains unclear. We examined these issues within a mathematical framework of arterial drug distribution and receptor binding following stent elution. […]

EuroIntervention: Angiographic and Histological Results Following Implantation of a Novel Stent-On-A-Wire in the Animal Model

Diletti R, Garcia-Garcia HM, van Geuns RJ, Farooq V, Bailey L, Rousselle S, Kopia G, Easterbrook W, Pomeranz M, Serruys P. Angiographic and Histological Results Following Implantation of a Novel Stent-On-A-Wire in the Animal Model. Summary: The Svelte Stent-On-A-Wire (SOAW) is a thin strut novel device consisting of a balloon-expandable cobalt-chromium stent premounted onto a single […]