Kilpatrick AF, Williams-Fritze MJ, Hayward, A. A Novel Liquid Diet for Use in Swine. Summary: CBSET researchers publish a novel liquid diet optimized for visualization of the upper or lower gastrointestinal tract in swine during device or equipment evaluation. ALN 7/17/2015. Full Academic Lab News article available here
Category Archives: Publications
Sci Transl Med: Arterial microanatomy determines the success of energy-based renal denervation in controlling hypertension
Tzafriri AR, Keating JH, Markham PM, Spognardi AM, L Stanley JR, Wong G, Zani BG, Highsmith D, O’Fallon P, Fuimaono K, Mahfoud F, Edelman ER. Arterial microanatomy determines the success of energy-based renal denervation in controlling hypertension. Summary: Renal denervation (RDN) is a treatment option for patients with hypertension resistant to conventional therapy. Clinical trials […]
EuroIntervention: Particulates from hydrophilic-coated guiding sheaths embolise to the brain
Stanley JR, Tzafriri AR, Regan K, LaRochelle A, Wong G, Zani BG, Markham PM, Bailey L, Spognardi A, Kopia GA, Edelman ER. Particulates from hydrophilic-coated guiding sheaths embolise to the brain. Summary: The hydrophilic coating on a clinically used guiding sheath readily avulses and embolises to the brain during deployment in a porcine model. Further documentation […]
Science Translational Medicine: Regulation of dendrimer/dextran material performance by altered tissue microenvironment in inflammation and neoplasia
Oliva N, Carcole M, Beckerman M, Seliktar S, Hayward A, Stanley J, Parry NM, Edelman ER, Artzi N. Regulation of dendrimer/dextran material performance by altered tissue microenvironment in inflammation and neoplasia. Summary: A “one material fits all” mindset ignores profound differences in target tissues that affect their responses and reactivity. Yet little attention has been paid to […]
Circ Cardiovasc Interv: Comparison of renal artery, soft tissue, and nerve damage after irrigated versus nonirrigated radiofrequency ablation
Sakakura K, Ladich E, Fuimaono K, Grunewald D, O’Fallon P, Spognardi AM, Markham P, Otsuka F, Yahagi K, Shen K, Kolodgie FD, Joner M, Virmani R. Comparison of renal artery, soft tissue, and nerve damage after irrigated versus nonirrigated radiofrequency ablation. Summary: The long-term efficacy of radiofrequency ablation of renal autonomic nerves has been proven in […]
J Am Coll Cardiol: Innervation patterns may limit response to endovascular renal denervation
Tzafriri AR, Mahfoud F, Keating JH, Markham PM, Spognardi A, Wong G, Fuimaono K, Böhm M, Edelman ER. Innervation patterns may limit response to endovascular renal denervation. Summary: The purpose of this study was to correlate response to endovascular radiofrequency ablation of renal arteries with nerve and ganglia distributions. We examined how renal neural network anatomy affected […]
JACC Cardiovasc Interv: Methodological Standardization for the Pre-Clinical Evaluation of Renal Sympathetic Denervation
Sakakura K, Ladich E, Edelman ER, Markham P, Stanley JR, Keating J, Kolodgie FD, Virmani R, Joner M..Methodological Standardization for the Pre-Clinical Evaluation of Renal Sympathetic Denervation. Summary: Transcatheter ablation of renal autonomic nerves is a viable option for the treatment of resistant arterial hypertension; however, structured pre-clinical evaluation with standardization of analytical procedures remains a […]
Cardiovascular Research: Extent of flow recirculation governs expression of atherosclerotic and thrombotic biomarkers in arterial bifurcations
Martorell, Santomá, Kolandaivelu, Kolachalama, Melgar-Lesmes, Molins, García, Edelman, Balcells. Extent of flow recirculation governs expression of atherosclerotic and thrombotic biomarkers in arterial bifurcations. Summary: Atherogenesis, evolution of plaque, and outcomes following endovascular intervention depend heavily on the unique vascular architecture of each individual. Patient-specific, multiscale models able to correlate changes in microscopic cellular responses with relevant […]
J Hypertens: Evaluation of renal nerve morphological changes and norepinephrine levels following treatment with novel bipolar radiofrequency delivery systems in a porcine model.
Cohen-Mazor M, Mathur P, Stanley JR, Mendelsohn FO, Lee H, Baird R, Zani BG, Markham PM, Rocha-Singh K. Evaluation of renal nerve morphological changes and norepinephrine levels following treatment with novel bipolar radiofrequency delivery systems in a porcine model. Summary: A porcine model (N = 46) was used to investigate renal norepinephrine levels and changes to renal artery […]
Vascular: Preclinical evaluation of the InCraft® aortic endograft in a sheep model.
Teigen C, Stanley JR, Johnsont P, Gross C. Preclinical evaluation of the InCraft® aortic endograft in a sheep model. Summary: Animal models remain the gold standard for the preclinical evaluation of tissue response, sealing and integrity of aortic endografts. Preclinical testing of the InCraft® device was performed to evaluate these attributes. Through the femoral arteries of eight […]