McSweeney AL, Zani BG, Baird R, Stanley JR, Hayward A, Markham PM, Kopia GA, Edelman ER, Rabiner R. Biocompatibility, bone healing, and safety evaluation in rabbits with an IlluminOss bone stabilization system Summary: Cone healing, biocompatibility, and safety employing the IlluminOss System (IS), comprised of an inflatable balloon filled with photopolymerizable liquid monomer, was evaluated […]
Nicola Di Girolamo DMV, PhD; Laura Bongiovanni DMV; Silvia Ferro DMV; Raffaele Melidone DMV; Annalisa Nicoletti DMV; Valeria Del Duca DMV; Thomas M. Donnelly DVM; Paolo Selleri DMV, PhD. Cystoscopic diagnosis of polypoid cystitis in two pet rabbits. Summary: A 5-year-old male Dwarf rabbit and 4-year-old female Mini-Rex rabbit were evaluated because of anorexia and urine […]
Richard J. Davis, Nazia M. Alam, Cuiping Zhao, Claudia Mueller, Janmeet S. Saini, Timothy A. Blenkinsop, Francesca Mazzoni, Melissa Campbell, Susan M. Borden, Carol J. Charniga, Patty L. Lederman, Vanessa Aguilar, Michael Naimark, Michael Fiske, Nathan Boles, Sally Temple, Silvia C. Finnemann, Glen T. Prusky, and Jeffrey H. Stern. The Developmental Stage of Adult Human Stem […]
Kolandaivelu K, Bailey L, Buzzi S, Zucker A, Milleret V, Ziogas A, Ehrbar M, Khattab AA, Stanley JRL, Wong GK, Zani B, Markham PM, Tzafriri AR, Bhatt DL, Edelman ER. Ultra-hydrophilic stent platforms promote early vascular healing and minimise late tissue response: a potential alternative to second-generation drug-eluting stents. Summary: Simple surface modifications can enhance coronary […]
Li J, Tzafriri R, Patel SM, Parikh SA. Mechanisms Underlying Drug Delivery to Peripheral Arteries. Summary: Delivery of drugs onto arterial targets via endovascular devices commands several principles: dissolution, diffusion, convection, drug binding, barriers to absorption, and interaction between the drug, delivery vehicle, and accepting arterial wall. The understanding of drug delivery in the coronary […]
Georgia S. Karanasiou, Michail I. Papafaklis, Claire Conway, Lampros K. Michalis, Rami Tzafriri, Elazer R. Edelman, Dimitrios I. Fotiadis. Stents: Biomechanics, Biomaterials, and Insights from Computational Modeling Summary: Coronary stents have revolutionized the treatment of coronary artery disease. Improvement in clinical outcomes requires detailed evaluation of the performance of stent biomechanics and the effectiveness as well […]
by Michael Naimark, Director of Business Development, CBSET, Inc. Regenerative and cell-based therapies have only recently begun to deliver on the promise they have portended for years, creating opportunities to positively impact patient outcomes and professional success. In the same way that these new and exciting biological approaches have the potential to revolutionize therapeutics, their […]
S Ewen; C Ukena; T Luscher; M Bergmann; P Blankestijn; B Cremers; E Blessing; O Doerr; H Nef; M Schlaich; F Sharif; MVoskuil; T Zeller; AR Tzafriri; E Edelman; Ml Boehm; FMahfoud. Anatomical and procedural determinants of catheter-based renal denervation Summary: Catheter-based renal sympathetic denervation (RDN) can reduce blood pressure (BP) and sympathetic activity in certain […]
K Nakamura, MD; JH Keating, DVM; ER Edelman, MD, PhD. Pathology of Endovascular Stents. Summary: Coronary artery disease (CAD) represents the leading cause of death worldwide, attributed to more than 17.5 million deaths annually, accounting for approximately 1 of every 3 deaths. In the United States, contemporary decreases in CAD-related mortality correlate with the 2 decades after the Surgeon General report […]
AR Tzafriri, PhD; ER Edelman, MD, PhD. Endovascular Drug Delivery and Drug Elution Systems: First Principles. Summary: Endovascular drug delivery continues to revolutionize the treatment of atherosclerosis in coronary and peripheral vasculature. The key has been to identify biological agents that can counter the hyperplastic tissue responses to device expansion/implantation and to develop effective local delivery […]