Ngan F. Huang, Michael Naimark, Rami Tzafriri. “Stem cell therapies for peripheral arterial disease: clinical status, promising biomaterials strategies and tips for successful translation” Summary: Cell transplantation into the ischemic tissue is being studied as a therapeutic strategy to re-establish functional collateral networks that supply oxygenated blood and preserve tissue viability. While the clinical picture is evolving, […]
Tag Archives: RT
Cardiovascular Revascularization Medicine: Anatomical and procedural determinants of ambulatory blood pressure lowering following catheter-based renal denervation using radiofrequency
Lauder L, Ewen S, Tzafriri AR, Edelman ER, Cremers B, Kulenthiran S, Ukena C, Linz D, Kindermann I, Tsioufis C, Scheller B, Böhm M, Mahfoud F. Anatomical and procedural determinants of ambulatory blood pressure lowering following catheter-based renal denervation using radiofrequency. Summary: Because little is known of the impact of renal anatomy and procedural parameters […]
Eurointervention: Renal artery anatomy assessed by quantitative analysis of selective renal artery in 1000 patients with hypertension
Lauder L, Ewen S, Tzafriri AR, Edelman ER, Lüscher TF, Blankenstijn PJ, Dörr O, Schlaich M, Sharif F, Voskuil M, Zeller T, Ukena C, Scheller B, Böhm M, Mahfoud F; Renal artery anatomy in hypertensive patients study collaborators. Renal artery anatomy assessed by quantitative analysis of selective renal artery in 1000 patients with hypertension. Summary: […]
Journal of Controlled Release: Defining drug and target protein distributions after stent-based drug release: Durable versus deployable coatings
Tzafriri AR, Garcia-Polite F, Li X, Keating J, Balaguer JM, Zani B, Bailey L, Markham P, Kiorpes TC, Carlyle W, Edelman ER. Defining drug and target protein distributions after stent-based drug release: Durable versus deployable coatings. Summary: Innovations in drug eluting stent designs make it increasingly important to develop models for differentiating performance through spatial […]
EuroIntervention: Lost in translational filters between peers
Kolandaivelu K, Tzafriri AR. Lost in translational filters between peers. Summary: In a recent issue of EuroIntervention, two articles(1)(2) and an editorial(3) detailed the translational journey taken by Qvanteq’s ultra-hydrophilic stent platform. Bench-top studies and animal experiments in two species of swine as well as rabbits suggested that a reduction in restenosis and stent thrombosis might […]
Journal of Controlled Release: Calcified plaque modification alters local drug delivery in the treatment of peripheral atherosclerosis
Abraham R. Tzafriri, Fernando Garcia-Polite, Brett Zani, James Stanley, Benny Muraj, Jennifer Knutson, Robert Kohler, Peter Markham, Alexander Nikanorov, Elazer R. Edelman. Calcified plaque modification alters local drug delivery in the treatment of peripheral atherosclerosis Summary: Calcific atherosclerosis is a major challenge to intraluminal drug delivery in peripheral artery disease (PAD). We evaluated the effects of […]
EuroIntervention: Ultra-hydrophilic stent platforms promote early vascular healing and minimise late tissue response: a potential alternative to second-generation drug-eluting stents
Kolandaivelu K, Bailey L, Buzzi S, Zucker A, Milleret V, Ziogas A, Ehrbar M, Khattab AA, Stanley JRL, Wong GK, Zani B, Markham PM, Tzafriri AR, Bhatt DL, Edelman ER. Ultra-hydrophilic stent platforms promote early vascular healing and minimise late tissue response: a potential alternative to second-generation drug-eluting stents. Summary: Simple surface modifications can enhance coronary […]
Interventional Cardiology Clinics: Mechanisms Underlying Drug Delivery to Peripheral Arteries.
Li J, Tzafriri R, Patel SM, Parikh SA. Mechanisms Underlying Drug Delivery to Peripheral Arteries. Summary: Delivery of drugs onto arterial targets via endovascular devices commands several principles: dissolution, diffusion, convection, drug binding, barriers to absorption, and interaction between the drug, delivery vehicle, and accepting arterial wall. The understanding of drug delivery in the coronary […]
Annals of Biomedical Engineering: Stents: Biomechanics, Biomaterials, and Insights from Computational Modeling
Georgia S. Karanasiou, Michail I. Papafaklis, Claire Conway, Lampros K. Michalis, Rami Tzafriri, Elazer R. Edelman, Dimitrios I. Fotiadis. Stents: Biomechanics, Biomaterials, and Insights from Computational Modeling Summary: Coronary stents have revolutionized the treatment of coronary artery disease. Improvement in clinical outcomes requires detailed evaluation of the performance of stent biomechanics and the effectiveness as well […]
Cardiovascular Revascularization Medicine: Anatomical and Procedural Determinants of Catheter-based Renal Denervation
S Ewen; C Ukena; T Luscher; M Bergmann; P Blankestijn; B Cremers; E Blessing; O Doerr; H Nef; M Schlaich; F Sharif; MVoskuil; T Zeller; AR Tzafriri; E Edelman; Ml Boehm; FMahfoud. Anatomical and procedural determinants of catheter-based renal denervation Summary: Catheter-based renal sympathetic denervation (RDN) can reduce blood pressure (BP) and sympathetic activity in certain […]