CBSET Director of Research and Innovation, Rami Tzafriri, PhD, presented: “Porcine Model of Catheter Based Treatment of Pulmonary Embolization” as part of the session From Pulmonary Embolism to Pulmonary Hypertension at the ICI for All 2024 meeting in Tel Aviv, Israel. In this invited presentation, Dr. Tzafriri reviewed CBSET’s innovative porcine clot models and their […]
Linnea Tscheuschner, Abraham R. Tzafriri. Cardiovascular Tissue Engineering Models for Atherosclerosis Treatment Development. In the early years of tissue engineering, scientists focused on the generation of healthy-like tissues and organs to replace diseased tissue areas with the aim of filling the gap between organ demands and actual organ donations. Over time, the realization has set […]
Rami Tzafriri, PhD; Jay Budrewicz, ScM, LATG, SRT; Anna Maria Spognardi, BA; Eric A. Secemsky, MD. Imaging-Based Evaluation and Differentiation of Vessel Preparation Technologies in a Porcine Model of Peripheral Artery Stenosis. PURPOSE: We evaluated surface modification effects of micro-incision and debulking preparation technologies on complex porcine peripheral in-stent restenosis lesions (ISRL). METHODS: Bilateral ISRL […]
Rami Tzafriri, Lee-Jae Jack Guo, Benny Muraj, Peter Markham, Curtis Genstler, Joseph Czyscon, Christopher Piere, Christopher Knapp, Elazer R. Edelman. Ultrasound-enhanced clot thrombolysis in a porcine model of pulmonary embolism. BACKGROUND: Catheter directed thrombolysis (CDT) delivering Tissue Plasminogen Activator (tPA) and Ultrasound (US) has shown clinical benefit, but the additional in vivo impact of US […]
Stratakos E, Antonini L, Poletti G, Berti F, Tzafriri AR, Petrini L, Pennati G. Investigating Balloon-Vessel Contact Pressure Patterns in Angioplasty: In Silico Insights for Drug-Coated Balloons. Drug-coated balloons have shown promising results as a minimally invasive approach to treat stenotic arteries, but recent animal studies have revealed limited, non-uniform coating transfer onto the arterial […]
Helge Struthoff, Lucas Lauder, Mathias Hohl, Alexander Hermens, Abraham Rami Tzafriri, Elazer R Edelman, Michael Kunz, Michael Böhm, Thomas Tschernig, Felix Mahfoud. “Histological examination of renal nerve distribution, density, and function in humans” Background: Renal denervation is optimised when guided by knowledge of nerve distribution. Aims: We aimed to assess sympathetic nerve distribution along the […]
Rami Tzafriri, Lee-Jae Jack Guo, Benny Muraj, Peter Markham, Curtis Genstler, Joseph Czyscon, Christopher Piere, Christopher Knapp, Elazer R. Edelman. Ultrasound-enhanced clot thrombolysis in a porcine model of pulmonary embolism. Ultrasound-assisted catheter-directed thrombolysis enhances right ventricular recovery after acute PE, but optimization is limited by lack of good animal models. We developed a porcine model […]
This presentation by Rami Tzafriri, CBSET’s Director of Research and Innovation reviewed: The scientific data underlying the procedural dependence of radiofrequency (RF) denervation therapies, including a strong dependence of thermal distribution on the locations of the treating electrodes relative to nerves, veins and lymph nodes. Computational modeling results comparing the thermal patterns achieved by RF […]
Abraham Rami Tzafriri PhD, Fernando Garcia-Polite PhD, John Keating DVM DACVP, Raffaele Melidone DVM DACVP, Jennifer Knutson BS, Peter Markham MS, Elazer R. Edelman MD PhD, Felix Mahfoud MD. “Morphometric analysis of the human common hepatic artery (CHA) reveals a rich and accessible target for sympathetic liver denervation.” FULL ARTICLE Summary: Treatment of type 2 […]
Georgia S Karanasiou, Panagiota I Tsompou, Nikolaos Tachos, Gianna E Karanasiou, Antonis Sakellarios, Savvas Kyriakidis, Luca Antonini, Giancarlo Pennati, Lorenza Petrini, Frank Gijsen, Farhad Rikhtegar Nezami, Rami Tzafriri, Martin Fawdry, Dimitrios I Fotiadis. “An in silico trials platform for the evaluation of effect of the arterial anatomy configuration on stent implantation.” Abstract: The introduction of […]