Biomaterials Forum: Embolization of Hydrophilic Coating from Catheters: Can Animal Models Predict Clinical Risk

Tzafriri, AR, Stanley, JR. ‘Embolization of Hydrophilic Coating from Catheters: Can Animal Models Predict Clinical Risk?’ Summary: Medical catheters permit minimally invasive external access for monitoring, imaging, sampling and local delivery of therapeutic agents, and placement of devices like endovascular stents, aneurysm coils and transcatheter valves. To improve ease of manipulation and deliverability the exterior surfaces […]

Sci Transl Med: Arterial microanatomy determines the success of energy-based renal denervation in controlling hypertension

Tzafriri AR, Keating JH, Markham PM, Spognardi AM, L Stanley JR, Wong G, Zani BG, Highsmith D, O’Fallon P, Fuimaono K, Mahfoud F, Edelman ER. Arterial microanatomy determines the success of energy-based renal denervation in controlling hypertension. Summary: Renal denervation (RDN) is a treatment option for patients with hypertension resistant to conventional therapy. Clinical trials […]

EuroIntervention: Particulates from hydrophilic-coated guiding sheaths embolise to the brain

Stanley JR, Tzafriri AR, Regan K, LaRochelle A, Wong G, Zani BG, Markham PM, Bailey L, Spognardi A, Kopia GA, Edelman ER. Particulates from hydrophilic-coated guiding sheaths embolise to the brain. Summary: The hydrophilic coating on a clinically used guiding sheath readily avulses and embolises to the brain during deployment in a porcine model. Further documentation […]

J Am Coll Cardiol: Innervation patterns may limit response to endovascular renal denervation

Tzafriri AR, Mahfoud F, Keating JH, Markham PM, Spognardi A, Wong G, Fuimaono K, Böhm M, Edelman ER. Innervation patterns may limit response to endovascular renal denervation. Summary: The purpose of this study was to correlate response to endovascular radiofrequency ablation of renal arteries with nerve and ganglia distributions. We examined how renal neural network anatomy affected […]

Biomaterials Forum: Computational Modeling of Biomaterial Degradation and Local Drug Release Facilitates Rapid Device Development, Enhanced Performance & Regulatory Evaluation

Tzafriri, AR, Artzi, N. Computational Modeling of Biomaterial Degradation and Local Drug Release Facilitates Rapid Device Development, Enhanced Performance & Regulatory Evaluation. Summary: Biodegradable materials are popular platforms for biocompatible and tunable local drug release. However, controlling and predicting material degradation dynamics, and the associated drug release kinetics in the complex in vivo environment often proves […]

Circulation: Mechanisms of Tissue Uptake and Retention in Zotarolimus-Coated Balloon Therapy

Vijaya B. Kolachalama, Stephen D. Pacetti, Joseph W. Franses, John J. Stankus, Hugh Q. Zhao, Tarek Shazly, Alexander Nikanorov, Lewis B. Schwartz, Abraham R. Tzafriri, Elazer R. Edelman. Mechanisms of Tissue Uptake and Retention in Zotarolimus-Coated Balloon Therapy Summary:Drug-coated balloons are increasingly used for peripheral vascular disease, and, yet, mechanisms of tissue uptake and retention […]

Journal of Controlled Release: Enhanced Drug Delivery Capabilities from Stents Coated with Absorbable Polymer and Crystalline Drug

Carlyle WC, McClain JB, Tzafriri AR, Bailey L, Zani BG, Markham PM, Stanley JR, Edelman ER. Enhanced Drug Delivery Capabilities from Stents Coated with Absorbable Polymer and Crystalline Drug. Summary: Current drug eluting stent (DES) technology is not optimized with regard to the pharmacokinetics of drug delivery. A novel, absorbable-coating sirolimus-eluting stent (AC-SES) was evaluated for […]

Journal of Controlled Release: Stent elution rate determines drug deposition and receptor-mediated effects

Tzafriri AR, Groothuis A, Price GS, Edelman ER. Stent elution rate determines drug deposition and receptor-mediated effects. Summary: Drug eluting stent designs abound and yet the dependence of efficacy on drug dose and elution duration remains unclear. We examined these issues within a mathematical framework of arterial drug distribution and receptor binding following stent elution. […]