Journal of Controlled Release: Lesion complexity determines arterial drug distribution after local drug delivery

Tzafriri A, Vukmirovic N, Kolachalama V, Astafieve I, Edelman ER. Lesion complexity determines arterial drug distribution after local drug delivery. Summary: Though stents are deployed in diseased arteries drug distribution has only been quantified in intact, non-diseased vessels. We correlated steady-state arterial drug distribution with tissue ultrastructure and composition in abdominal aortae from atherosclerotic human autopsy […]

Circulation: Vascular regeneration by local growth factor release is self-limited by microvascular clearance

Le KN, Hwang CW, Tzafriri A, Lovich MA, Hayward A, Edelman ER. Vascular regeneration by local growth factor release is self-limited by microvascular clearance. Summary: The challenge of angiogenesis science is that stable sustained vascular regeneration in humans has not been realized despite promising preclinical findings. We hypothesized that angiogenic therapies powerfully self-regulate by dynamically altering […]

Cell Proliferation: Diffusion-limited binding explains binary dose response for local arterial and tumor drug delivery

Tzafriri AR, Levin AD, Edelman ER. Diffusion-limited binding explains binary dose response for local arterial and tumor drug delivery. Summary: Local drug delivery has transformed medicine, yet it remains unclear how drug efficacy depends on physicochemical properties and delivery kinetics. Most therapies seek to prolong release, yet recent studies demonstrate sustained clinical benefit following local bolus […]

Journal of Controlled Release: Luminal flow patterns dictate arterial drug deposition in stent-based delivery

Kolachalama VB, Tzafriri AR, Arifin DY, Edelman ER. Luminal flow patterns dictate arterial drug deposition in stent-based delivery. Summary: Endovascular stents reside in a dynamic flow environment and yet the impact of flow on arterial drug deposition after stent-based delivery is only now emerging. We employed computational fluid dynamic modeling tools to investigate the influence of […]

Biochem J: Endosomal receptor kinetics determine the stability of intracellular growth factor signalling complexes

Tzafriri, A.R. and E.R. Edelman. Endosomal receptor kinetics determine the stability of intracellular growth factor signalling complexes. Summary: There is an emerging paradigm that growth factor signalling continues in the endosome and that cell response to a growth factor is defined by the integration of cell surface and endosomal events. As activated receptors in the endosome […]

Circulation: Strut position, blood flow, and drug deposition: implications for single and overlapping drug-eluting stents

Balakrishnan B, Tzafriri AR, Seifert P, Groothuis A, Rogers C, Edelman ER. Strut position, blood flow, and drug deposition: implications for single and overlapping drug-eluting stents. Summary: The intricacies of stent design, local pharmacology, tissue biology, and rheology preclude an intuitive understanding of drug distribution and deposition from drug-eluting stents (DES). Circulation 2005 Jun 7;111(22):2958-65.

Clinical Cancer Research: Mathematical modeling and optimization of drug delivery from intratumorally injected microspheres

Tzafriri AR et al. Mathematical modeling and optimization of drug delivery from intratumorally injected microspheres. Summary: Paclitaxel is a highly promising phase-sensitive antitumor drug that could conceivably be improved by extended lower dosing as opposed to intermittent higher dosing. Although intratumoral delivery of paclitaxel to the whole tumor at different loads and rates has already been […]

J Theor Biol: Analysis of compartmental models of ligand-induced endocytosis

Tzafriri, A.R., D. Wu, and E.R. Edelman. Analysis of compartmental models of ligand-induced endocytosis. Summary: Kinetic models have played a pivotal role in the study of ligand-induced endocytosis. However, an analysis that suggests a systematic way to validate such models is lacking. The current work analyses the base model of ligand-induced endocytosis for three widely used […]

Biophys J: Reaction diffusion model of the enzymatic erosion of insoluble fibrillar matrices

Tzafriri, A.R., M. Bercovier, and H. Parnas. Reaction diffusion model of the enzymatic erosion of insoluble fibrillar matrices. Summary: Predicting the time course of in vivo biodegradation is a key issue in the design of an increasing number of biomedical applications such as sutures, tissue analogs and drug-delivery devices. The design of such biodegradable devices is […]