Nuria Oliva, Sagi Shitreet, Eytan Abraham, Butch Stanley, Elazer R. Edelman, and Natalie Artzi. Natural Tissue Microenvironmental Conditions Modulate Adhesive Material Performance. Summary: We designed and optimized tissue-responsive adhesive materials by matching material and tissue properties. A two-component material based on dextran aldehyde and dendrimer amine provides a cohesive gel through aldehyde–amine cross-linking and an adhesive […]
Category Archives: Publications
Journal of Controlled Release: Enhanced Drug Delivery Capabilities from Stents Coated with Absorbable Polymer and Crystalline Drug
Carlyle WC, McClain JB, Tzafriri AR, Bailey L, Zani BG, Markham PM, Stanley JR, Edelman ER. Enhanced Drug Delivery Capabilities from Stents Coated with Absorbable Polymer and Crystalline Drug. Summary: Current drug eluting stent (DES) technology is not optimized with regard to the pharmacokinetics of drug delivery. A novel, absorbable-coating sirolimus-eluting stent (AC-SES) was evaluated for […]
Journal of Controlled Release: Stent elution rate determines drug deposition and receptor-mediated effects
Tzafriri AR, Groothuis A, Price GS, Edelman ER. Stent elution rate determines drug deposition and receptor-mediated effects. Summary: Drug eluting stent designs abound and yet the dependence of efficacy on drug dose and elution duration remains unclear. We examined these issues within a mathematical framework of arterial drug distribution and receptor binding following stent elution. […]
EuroIntervention: Angiographic and Histological Results Following Implantation of a Novel Stent-On-A-Wire in the Animal Model
Diletti R, Garcia-Garcia HM, van Geuns RJ, Farooq V, Bailey L, Rousselle S, Kopia G, Easterbrook W, Pomeranz M, Serruys P. Angiographic and Histological Results Following Implantation of a Novel Stent-On-A-Wire in the Animal Model. Summary: The Svelte Stent-On-A-Wire (SOAW) is a thin strut novel device consisting of a balloon-expandable cobalt-chromium stent premounted onto a single […]
Ann NY Acad Sci: Engineered arterial models to correlate blood flow to tissue biological response
Martorell J, Santoma P, Molins JJ, Garcia-Granada AA, Bea JA, Edelman ER, and Balcells M. Engineered arterial models to correlate blood flow to tissue biological response. Summary: This paper reviews how biomedical engineers, in collaboration with physicians, biologists, chemists, physicists, and mathematicians, have developed models to explain how the impact of vascular interventions on blood flow […]
Nature Materials: In vivo and in vitro tracking of erosion in biodegradable materials using non-invasive fluorescence imaging
Artzi N, Oliva N, Puron C, Shitreet S, Artzi S, bon Ramos A, Groothuis A, Sahagian G, Edelman ER. In vivo and in vitro tracking of erosion in biodegradable materials using non-invasive fluorescence imaging. Summary: The design of erodible biomaterials relies on the ability to program the in vivo retention time, which necessitates real-time monitoring of […]
Circulation: Stent thrombogenicity early in high-risk interventional settings is driven by stent design and deployment and protected by polymer-drug coatings.
Kolandaivelu, K., et al. Stent thrombogenicity early in high-risk interventional settings is driven by stent design and deployment and protected by polymer-drug coatings. Summary: Contrary to popular perception, drug/polymer coatings do not inherently increase acute stent clotting; they reduce thrombosis. However, strut dimensions and positioning relative to the vessel wall are critical factors in modulating stent […]
Atherosclerosis: Regulation of heparanase expression in coronary artery disease in diabetic hyperlipidemic swine
Baker A, Chatzizisis Y, Beigel R, Jonas M, Stone B, Coskun A, Maynard C, Rogers C, Koskinas K, Feldman C, Stone P, Edelman ER. Regulation of heparanase expression in coronary artery disease in diabetic hyperlipidemic swine. Summary: Enzymatic degradation of the extracellular matrix is known to be powerful regulator of atherosclerosis. However, little is known about […]
Circulation: Smooth muscle cells orchestrate the endothelial cell response to flow and injury
Balcells M, Martorell J, Olive C, Santacana M, Chitalia V, Cardoso A, Edelman ER. Smooth muscle cells orchestrate the endothelial cell response to flow and injury. Summary: Local modulation of vascular mammalian target of rapamycin (mTOR) signaling reduces smooth muscle cell (SMC) proliferation after endovascular interventions but may be associated with endothelial cell (EC) toxicity. The […]
J Heart Lung Transplant: T-helper 2 cells are essential for modulation of vascular repair by allogeneic endothelial cells
Methe H, Nanasato M, Spognardi AM, Groothuis A, Edelman ER. . T-helper 2 cells are essential for modulation of vascular repair by allogeneic endothelial cells. Summary: Endothelial cells (EC) embedded within three-dimensional matrices (MEEC) when placed in the vascular adventitia control lumenal inflammation and intimal hyperplasia. Matrix-embedding alters endothelial immunogenicity in vitro. T helper (Th) driven […]