Martorell J, Santoma P, Molins JJ, Garcia-Granada AA, Bea JA, Edelman ER, and Balcells M. Engineered arterial models to correlate blood flow to tissue biological response. Summary: This paper reviews how biomedical engineers, in collaboration with physicians, biologists, chemists, physicists, and mathematicians, have developed models to explain how the impact of vascular interventions on blood flow […]
Category Archives: Publications
Nature Materials: In vivo and in vitro tracking of erosion in biodegradable materials using non-invasive fluorescence imaging
Artzi N, Oliva N, Puron C, Shitreet S, Artzi S, bon Ramos A, Groothuis A, Sahagian G, Edelman ER. In vivo and in vitro tracking of erosion in biodegradable materials using non-invasive fluorescence imaging. Summary: The design of erodible biomaterials relies on the ability to program the in vivo retention time, which necessitates real-time monitoring of […]
Circulation: Stent thrombogenicity early in high-risk interventional settings is driven by stent design and deployment and protected by polymer-drug coatings.
Kolandaivelu, K., et al. Stent thrombogenicity early in high-risk interventional settings is driven by stent design and deployment and protected by polymer-drug coatings. Summary: Contrary to popular perception, drug/polymer coatings do not inherently increase acute stent clotting; they reduce thrombosis. However, strut dimensions and positioning relative to the vessel wall are critical factors in modulating stent […]
Atherosclerosis: Regulation of heparanase expression in coronary artery disease in diabetic hyperlipidemic swine
Baker A, Chatzizisis Y, Beigel R, Jonas M, Stone B, Coskun A, Maynard C, Rogers C, Koskinas K, Feldman C, Stone P, Edelman ER. Regulation of heparanase expression in coronary artery disease in diabetic hyperlipidemic swine. Summary: Enzymatic degradation of the extracellular matrix is known to be powerful regulator of atherosclerosis. However, little is known about […]
Circulation: Smooth muscle cells orchestrate the endothelial cell response to flow and injury
Balcells M, Martorell J, Olive C, Santacana M, Chitalia V, Cardoso A, Edelman ER. Smooth muscle cells orchestrate the endothelial cell response to flow and injury. Summary: Local modulation of vascular mammalian target of rapamycin (mTOR) signaling reduces smooth muscle cell (SMC) proliferation after endovascular interventions but may be associated with endothelial cell (EC) toxicity. The […]
J Heart Lung Transplant: T-helper 2 cells are essential for modulation of vascular repair by allogeneic endothelial cells
Methe H, Nanasato M, Spognardi AM, Groothuis A, Edelman ER. . T-helper 2 cells are essential for modulation of vascular repair by allogeneic endothelial cells. Summary: Endothelial cells (EC) embedded within three-dimensional matrices (MEEC) when placed in the vascular adventitia control lumenal inflammation and intimal hyperplasia. Matrix-embedding alters endothelial immunogenicity in vitro. T helper (Th) driven […]
Journal of Controlled Release: Lesion complexity determines arterial drug distribution after local drug delivery
Tzafriri A, Vukmirovic N, Kolachalama V, Astafieve I, Edelman ER. Lesion complexity determines arterial drug distribution after local drug delivery. Summary: Though stents are deployed in diseased arteries drug distribution has only been quantified in intact, non-diseased vessels. We correlated steady-state arterial drug distribution with tissue ultrastructure and composition in abdominal aortae from atherosclerotic human autopsy […]
PloS ONE: Luminal flow amplifies stent-based drug deposition in arterial bifurcations
Kolachalama VB, Levine EG, Edelman ER. Luminal flow amplifies stent-based drug deposition in arterial bifurcations. Summary: Treatment of arterial bifurcation lesions using drug-eluting stents (DES) is now common clinical practice and yet the mechanisms governing drug distribution in these complex morphologies are incompletely understood. It is still not evident how to efficiently determine the efficacy of […]
Circulation: Vascular regeneration by local growth factor release is self-limited by microvascular clearance
Le KN, Hwang CW, Tzafriri A, Lovich MA, Hayward A, Edelman ER. Vascular regeneration by local growth factor release is self-limited by microvascular clearance. Summary: The challenge of angiogenesis science is that stable sustained vascular regeneration in humans has not been realized despite promising preclinical findings. We hypothesized that angiogenic therapies powerfully self-regulate by dynamically altering […]
Journal of Controlled Release: Intramuscular drug transport under mechanical loading: resonance between tissue function and uptake
Wu, P.I., S. Minisini, and E.R. Edelman. Intramuscular drug transport under mechanical loading: resonance between tissue function and uptake. Summary: Dynamic architecture and motion in mechanically active target tissues can influence the pharmacokinetics of locally delivered agents. Drug transport in skeletal muscle under controlled mechanical loads was investigated. Static (0-20%) and cyclic (+/-2.5% amplitude, 0-20% mean, […]