Rami Tzafriri, Jay Budrewicz, Lynn Bailey, Peter Markham, Maxen Albaghdadi, Elazer Edelman. Lesion Modification with a Micro-Incision Vessel Preparation System Enhances Balloon-Based Drug Delivery in Complex Porcine Restenotic Lesions. Live presentation abstract: This study examined if and how a vessel preparation system delivering micro-incisions could enhance in vivo paclitaxel (delivered from a DCB) retention in […]
Abraham R. Tzafriri, Benny Muraj, Fernando Garcia-Polite, Antonio G. Salazar-Martín, Peter Markham, Brett Zani, Anna Spognardi, Mazen Albaghdadi, Steve Alston, Elazer R. Edelman. “Balloon-based drug coating delivery to the artery wall is dictated by coating micro-morphology and angioplasty pressure gradients.” Summary: Paclitaxel coated balloon catheters (PCB) were developed as a polymer-free non-implantable alternative to drug […]
Georgia S Karanasiou, Panagiota I Tsobou, Nikolaos S Tachos, Luca Antonini, Lorenza Petrini, Giancarlo Pennati, Frank Gijsen, Farhad Rikhtegar Nezami, Rami Tzafriri, Ted Vaughan, Martin Fawdry, Dimitrios I Fotiadis. “Design and implementation of in silico clinical trial for Bioresorbable Vascular Scaffolds.” Summary: In the recent years, Bioresorbable Vascular Scaffolds (BVS) for the treatment of atherosclerosis […]
Krishna J. Rocha-Sing , Sue Duval, Michael R. Jaff, Peter A. Schneider, Gary M. Ansel, Sean P. Lyden, Christopher M. Mullin, John P.A. Ioannidis, Sanjay Misra, Abraham R. Tzafriri, Elazer R. Edelman, Juan F. Granada, Christopher J. White, and Joshua A. Beckman. “Mortality and Paclitaxel-Coated Devices: An Individual Patient Data Meta-Analysis.” Summary: Paclitaxel-containing devices (PTXD) significantly […]
Chopra AM, Rapkiewicz A, Daggubati R, Sequeira A, Hu YC, Bhatt DL, Sharma SK, Cruz JP, Tzafriri AR, Edelman ER. “Analysis: Intravascular Devices with a Higher Risk of Polymer Emboli: The Need for Particulate Generation Testing.” Summary: Hydrophilic polymer coatings on intravascular devices lower friction between the device and vasculature, thereby reducing trauma during interventional procedures. […]
Abraham R.Tzafriri, Sahil A.Parikh, Elazer R.Edelman. “Taking paclitaxel coated balloons to a higher level: Predicting coating dissolution kinetics, tissue retention and dosing dynamics.” Summary: Paclitaxel coated balloons (PCBs) are a promising non-implantable alternative to drug-eluting stents, whereby drug is delivered to the arterial wall in solid form as a semi-continuous solid coating or as micro drug […]
Mazen Albaghdadi, Fernando Garcia-Polite, Brett Zani, John Keating, Raffaele Melidone, Anna Spognardi, Peter Markham, Abraham Tzafriri. “Splenic artery denervation: target micro-anatomy, feasibility, and early preclinical experience.” Summary: This study sought to evaluate perisplenic artery nerve distribution and the feasibility of splenic artery denervation (SDN). The NEXION radiofrequency catheter was used to perform SDN in healthy and […]
Hypertension editors selected this paper for their 2019 Fall Collection of High Impact Papers. Tzafriri AR, Mahfoud F, Keating JH, Spognardi AM, Markham PM, Wong G, Highsmith D, O’Fallon P, Fuimaono K, Edelman ER. Procedural and Anatomical Determinants of Multielectrode Renal Denervation Efficacy. Summary: Radiofrequency renal denervation is under investigation for treatment of hypertension with […]
Mazen Albaghdadi, Zhonglie Piao, Adam Mauskapf, Mohammed Chowdhury, Rami Tzafriri, Elazer Edelman, Guillermo Tearney, Farouc Jaffer. “In vivo Imaging Assessment of Arterial Permeability Using Indocyanine Green: Implications for Optimizing Drug-Coated Balloon Treatment of Atherosclerosis.” Summary: The efficacy of paclitaxel (PTX) drug-coated balloons (DCBs) in reducing restenosis is limited by Inadequate arterial permeability (AP), yet in vivo […]
Rothman A, Jonas M, Castel D, Tzafriri AR, Traxler H, Shav D, Leon MB, Ben-Yehuda O, Rubin L. “Pulmonary Artery Denervation Using Catheter based Ultrasonic Energy.” Summary: Pulmonary arterial hypertension is a devastating disease characterized by pulmonary vascular remodeling and right heart failure. Radio-frequency pulmonary artery denervation (PDN) improves pulmonary hemodynamics in pre-clinical and early clinical […]