Hypertension editors selected this paper for their 2019 Fall Collection of High Impact Papers. Tzafriri AR, Mahfoud F, Keating JH, Spognardi AM, Markham PM, Wong G, Highsmith D, O’Fallon P, Fuimaono K, Edelman ER. Procedural and Anatomical Determinants of Multielectrode Renal Denervation Efficacy. Summary: Radiofrequency renal denervation is under investigation for treatment of hypertension with […]
Category Archives: Publications
EuroIntervention: Pulmonary Artery Denervation Using Catheter based Ultrasonic Energy.
Rothman A, Jonas M, Castel D, Tzafriri AR, Traxler H, Shav D, Leon MB, Ben-Yehuda O, Rubin L. “Pulmonary Artery Denervation Using Catheter based Ultrasonic Energy.” Summary: Pulmonary arterial hypertension is a devastating disease characterized by pulmonary vascular remodeling and right heart failure. Radio-frequency pulmonary artery denervation (PDN) improves pulmonary hemodynamics in pre-clinical and early clinical […]
Toxicologic Pathology: Preclinical Evaluation of Mesh Implants: The Pathologist’s Perspective
Keating JH, Melidone R, Garcia-Polite F. “Preclinical Evaluation of Mesh Implants: The Pathologist’s Perspective.” Summary: Surgical and laparoscopic implantation of mesh devices is on the rise for a variety of applications. The complexity and range of evolving mesh designs calls for consistent and detailed pathologic evaluation in determining host responses and assessing overall safety. This review […]
Toxicologic Pathology: An Overview on the Considerations for the Planning of Nonclinical Necropsies for Medical Device Studies
Stanley JRL, Keating JH, San Souci KJ. “An Overview on the Considerations for the Planning of Nonclinical Necropsies for Medical Device Studies” Summary: The terminal collection and histological processing of medical devices is an expensive, labor-, and material-intensive endeavor, which requires adequate experience, innovation, and preparation for success. It is also an exciting endeavor that continually […]
Not a Single Drug Is Approved to Treat Hearing Loss, but Now There Is Hope
CBSET / CILcare Partnership Supports “World Hearing Day 2019,” Sponsored by the World Health Organization (WHO) on March 3rd, to Make Hearing a Priority 1. Hearing loss is at epidemic prevalence. According to the National Institutes of Health (NIH), about three out of every 1,000 children in the United States are born with a detectable level […]
Catheterization and Cardiovascular Interventions: Fracture in drug-eluting stents increases focal intimal hyperplasia in the atherosclerosed rabbit iliac artery
Conway C, Desany GJ, Bailey LR, Keating JH, Baker BL, Edelman ER. Fracture in drug-eluting stents increases focal intimal hyperplasia in the atherosclerosed rabbit iliac artery. Summary: Controlled release of therapeutic agents, such as sirolimus and its analogs, or paclitaxel, has reduced tissue-based drug-eluting stent failure modes compared to bare metal stents. In the stent, restenosis […]
International Journal of Toxicology: Percutaneous Hepatic Perfusion With Filtered Melphalan for Localized Treatment of Metastatic Hepatic Disease: A Risk Assessment
Pauline E McEwan, Lynn Bailey, David Trost, Christopher Scull, John H Keating, Misty Williams, Robert J Guttendorf. Percutaneous Hepatic Perfusion With Filtered Melphalan for Localized Treatment of Metastatic Hepatic Disease: A Risk Assessment. Summary: Regional therapies for metastatic liver disease have garnered interest in recent years due to technological advances in drug delivery. A percutaneous […]
Biomaterials Forum: Stem cell therapies for peripheral arterial disease: clinical status, promising biomaterials strategies and tips for successful translation
Ngan F. Huang, Michael Naimark, Rami Tzafriri. “Stem cell therapies for peripheral arterial disease: clinical status, promising biomaterials strategies and tips for successful translation” Summary: Cell transplantation into the ischemic tissue is being studied as a therapeutic strategy to re-establish functional collateral networks that supply oxygenated blood and preserve tissue viability. While the clinical picture is evolving, […]
Cardiovascular Revascularization Medicine: Anatomical and procedural determinants of ambulatory blood pressure lowering following catheter-based renal denervation using radiofrequency
Lauder L, Ewen S, Tzafriri AR, Edelman ER, Cremers B, Kulenthiran S, Ukena C, Linz D, Kindermann I, Tsioufis C, Scheller B, Böhm M, Mahfoud F. Anatomical and procedural determinants of ambulatory blood pressure lowering following catheter-based renal denervation using radiofrequency. Summary: Because little is known of the impact of renal anatomy and procedural parameters […]
Eurointervention: Renal artery anatomy assessed by quantitative analysis of selective renal artery in 1000 patients with hypertension
Lauder L, Ewen S, Tzafriri AR, Edelman ER, Lüscher TF, Blankenstijn PJ, Dörr O, Schlaich M, Sharif F, Voskuil M, Zeller T, Ukena C, Scheller B, Böhm M, Mahfoud F; Renal artery anatomy in hypertensive patients study collaborators. Renal artery anatomy assessed by quantitative analysis of selective renal artery in 1000 patients with hypertension. Summary: […]