World Pharma Today, August 24, 2020 Authors: Wahid Awad, PhD, Chief Business Officer, CILcare and Michael Naimark, Director of Business Development, CBSET, Inc. As the COVID-19 pandemic continues to spread across the world, clinicians, academic institutions, private organizations, and governments are working tirelessly to find treatments to help patients and at-risk populations threatened by this […]
Georgia S Karanasiou, Panagiota I Tsobou, Nikolaos S Tachos, Luca Antonini, Lorenza Petrini, Giancarlo Pennati, Frank Gijsen, Farhad Rikhtegar Nezami, Rami Tzafriri, Ted Vaughan, Martin Fawdry, Dimitrios I Fotiadis. “Design and implementation of in silico clinical trial for Bioresorbable Vascular Scaffolds.” Summary: In the recent years, Bioresorbable Vascular Scaffolds (BVS) for the treatment of atherosclerosis […]
Hagai Yavin, Ayelet Shapira-Daniels, Michael Barkagan, Jakub Sroubek, David Shim, Raffaele Melidone, Elad Anter. “Pulsed Field Ablation Using a Lattice Electrode for Focal Energy Delivery: Biophysical Characterization, Lesion Durability, and Safety Evaluation.” Summary: Pulsed field ablation (PFA) is a nonthermal energy that may provide safety advantages over radiofrequency ablation (RFA). One-shot PFA catheters have been developed […]
Krishna J. Rocha-Sing , Sue Duval, Michael R. Jaff, Peter A. Schneider, Gary M. Ansel, Sean P. Lyden, Christopher M. Mullin, John P.A. Ioannidis, Sanjay Misra, Abraham R. Tzafriri, Elazer R. Edelman, Juan F. Granada, Christopher J. White, and Joshua A. Beckman. “Mortality and Paclitaxel-Coated Devices: An Individual Patient Data Meta-Analysis.” Summary: Paclitaxel-containing devices (PTXD) significantly […]
Chopra AM, Rapkiewicz A, Daggubati R, Sequeira A, Hu YC, Bhatt DL, Sharma SK, Cruz JP, Tzafriri AR, Edelman ER. “Analysis: Intravascular Devices with a Higher Risk of Polymer Emboli: The Need for Particulate Generation Testing.” Summary: Hydrophilic polymer coatings on intravascular devices lower friction between the device and vasculature, thereby reducing trauma during interventional procedures. […]
Sanchez S, Bailey L, Ducore R, Andersson T, Nogueira R, Cognard C, Ribo M, Villanova H, Rios A, Galve I. “Preclinical evaluation of the ANCD thrombectomy device: safety and efficacy in a swine clot model” Summary: The Advanced Thrombectomy System (ANCD) provides a new funnel component designed to reduce clot fragmentation and facilitate retrieval in patients […]
Barber FA, Spenciner DB, Zani BG, Melidone R. “Suture-Based Debris Behavior in the Draining Lymph Nodes of a Porcine Knee: A Study of Silicone, Polyethylene and Carbon.” Purpose/Methods: To determine whether debris from a silicone core suture has an observable intra-articular or extra-articular impact or can be shown to migrate into the lymphatic system. Using […]
Abraham R.Tzafriri, Sahil A.Parikh, Elazer R.Edelman. “Taking paclitaxel coated balloons to a higher level: Predicting coating dissolution kinetics, tissue retention and dosing dynamics.” Summary: Paclitaxel coated balloons (PCBs) are a promising non-implantable alternative to drug-eluting stents, whereby drug is delivered to the arterial wall in solid form as a semi-continuous solid coating or as micro drug […]
Spenciner DB, Barber FA, Zani BG, Melidone R, Muench TR. “Development of a Porcine Lymph Drainage Model to Study Particle Migration.” Summary: Intra-articular wear particulate migration from the knee joint has been studied in various animal models as well as postmortem in patients who received total knee joint replacement. However, there still exists a need […]
Mazen Albaghdadi, Fernando Garcia-Polite, Brett Zani, John Keating, Raffaele Melidone, Anna Spognardi, Peter Markham, Abraham Tzafriri. “Splenic artery denervation: target micro-anatomy, feasibility, and early preclinical experience.” Summary: This study sought to evaluate perisplenic artery nerve distribution and the feasibility of splenic artery denervation (SDN). The NEXION radiofrequency catheter was used to perform SDN in healthy and […]