“Understanding and computationally modeling the determinants of drug release kinetics and tissue distribution can help further drive innovation at reduced cost.” – Rami Tzafriri, PhD, Principal Scientist, CBSET “Endovascular Drug Delivery and Drug Elution Systems: First Principles” Abraham Rami Tzafriri, PhD Elazer Reuven Edelman, MD, PhD “…The first principles outlined…serve as a handbook for features […]
“We have developed a preclinical paradigm for predictably modulating the efficacy of thermal ablation devices while minimizing adverse effects on target and surrounding tissues,” said Dr. John H. Keating, Director of Pathology, CBSET. LEXINGTON, Mass., March 10, 2016 — Scientists at CBSET, a not-for-profit preclinical research institute dedicated to biomedical research, education, and advancement of medical […]
“Vascular access complications are a significant source of morbidity, especially for interventions such as TAVR that require large bore cannulation,” said Haim Danenberg, M.D., CBSET’s chief scientific advisor. “CBSET’s study demonstrates that MANTA is a safe and reliable large-bore percutaneous closure device.” LEXINGTON, Mass., Dec. 10, 2015 — Scientists at CBSET, a not-for-profit preclinical research […]
“Drug eluting stents remain a ripe field for continued innovation. Until now, the focus on sustainable drug elution has strictly limited the choice of DES coating materials. Our study results confirm a new paradigm for optimizing coating biocompatibility,” said Rami Tzafriri, PhD, Principal Scientist, CBSET. LEXINGTON, Mass., Oct. 28, 2015 — CBSET, a not-for-profit preclinical […]
““This preclinical study could have a significant clinical impact by demonstrating improved drug delivery after modification of calcified lesions,” said Gunnar Tepe, M.D., RoMed Hospital, Rosenheim, Germany. LEXINGTON, Mass., May 20, 2015 — CBSET, a not-for-profit preclinical research institute dedicated to biomedical research, education, and advancement of medical technologies, disclosed today that modification of atherosclerotic […]
May 20, 2015—CBSET, a preclinical biomedical research institute, announced findings from a cadaver study suggesting that modification of atherosclerotic plaque with the Diamondback 360 orbital atherectomy system (Cardiovascular Systems, Inc. [CSI]) improved drug uptake in calcified peripheral lesions. Gunnar Tepe, MD, from RoMed Hospital in Rosenheim, Germany, stated in CBSET’s announcement, “This preclinical study could have a significant […]
“Renal denervation, despite recent stumbles, is experiencing a resurgence with next-generation device design. CBSET’s incontrovertible mechanistic data provides the pathway for predicting efficacy and designing more efficacious devices and protocols,” said Peter M. Markham, President and CEO, CBSET. LEXINGTON, Mass., May 18, 2015 — Scientists at CBSET, a not-for-profit preclinical research institute dedicated to biomedical research, […]
“The combination of both preclinical experiments and computational models is necessary to understand the basis of clinical efficacy: variation in ablation zone geometry caused by diversity in local tissue anatomy,” said Peter M. Markham, President and CEO, CBSET. LEXINGTON, Mass., May 4, 2015 — CBSET, a not-for-profit preclinical research institute dedicated to biomedical research, education, and […]
May 4, 2015—CBSET, a not-for-profit preclinical research institute, announced that its scientists have published data and analyses that provide critical insights into the predictability, variability, and treatment success of catheter-based renal denervation (RDN) therapy. These data suggest that new, optimal alternative devices compared to first-generation RDN systems may enhance or assure efficacy, stated CBSET. The […]
IlluminOss System provides minimally invasive approach to replace splints, casts, metal fixator plates and intramedullary rods to stabilize high load-bearing bones* LEXINGTON, Mass., April 10, 2015 — CBSET, a not-for-profit preclinical research institute dedicated to biomedical research, education, and advancement of medical technologies, announced today it has published efficacy data showing that percutaneous intramedullary fixation […]