Join CBSET at TCT 2024 which will be held at the Walter E. Washington Convention Center in Washington, DC, October 27-30, 2024.
This year's meeting will include a comprehensive program to foster engagement and interactive case-based learning with a diverse line-up of faculty.
As a member of the faculty, Rami Tzafriri, CBSET's Director of Research and Innovation, will be at this event.
CBSET presentations include:
Twelve Week Safety and Efficacy of a Novel Extravascular Bi-lateral Renal Denervation Device in a Porcine Model at Nominal Dose. Rami Tzafriri, PhD, CBSET Director of Research and Innovation.
Drug-Loss at Arterial Bends Can Dominate Off-Target Drug Delivery by Paclitaxel-Coated Balloons. Linnea Tscheuschner, early-stage DECODE researcher/Marie Skłodowska-Curie PhD candidate.
Learn more about CBSET's work on Sympathetic Denervation.
Learn more about CBSET's work on Peripheral Artery Disease (PAD).
Learn more about CBSET's approach to the study of Thrombectomy & Thrombolysis technologies.CBSET-authored scientific papers related to Sympathetic Denervation:
Histological examination of renal nerve distribution, density, and function in humans. Helge Struthoff, Lucas Lauder, Mathias Hohl, Alexander Hermens, Abraham Rami Tzafriri, Elazer R Edelman, Michael Kunz, Michael Böhm, Thomas Tschernig, Felix Mahfoud. EuroIntervention. 2023 Jul 28;EIJ-D-23-00264. doi: 10.4244/EIJ-D-23-00264.
Morphometric analysis of the human common hepatic artery (CHA) reveals a rich and accessible target for sympathetic liver denervation. Abraham Rami Tzafriri PhD, Fernando Garcia-Polite PhD, John Keating DVM DACVP et al. Scientific Reports, 10.1038/s41598-022-05475-6
Combined renal and common hepatic artery denervation as a novel approach to reduce cardiometabolic risk: technical approach, feasibility and safety in a pre-clinical model. Márcio Galindo Kiuchi, Kavitha Ganesan, John Keating et al. Clin Res Cardiol. 2021 May;110(5):740-753. doi: 10.1007/s00392-021-01814-1.
Pulsed Field Ablation Using a Lattice Electrode for Focal Energy Delivery: Biophysical Characterization, Lesion Durability, and Safety Evaluation. Hagai Yavin, Ayelet Shapira-Daniels, Michael Barkagan, Jakub Sroubek, David Shim, Raffaele Melidone, Elad Anter. Circulation: Arrhythmia and Electrophysiology 2020 Jun;13(6):e008580.
Procedural and Anatomical Determinants of Multi-Electrode Renal Denervation: Preclinical Versus Clinical. Abraham Tzafriri, PhD. Invited presentation at: CRT 2020, Feb 22-25; National Harbor, MD.
Splenic artery denervation: target micro-anatomy, feasibility, and early preclinical experience. Mazen Albaghdadi, Fernando Garcia-Polite, Brett Zani et al. Translational Research. doi:10.1016/j.trsl.2019.07.012.
Procedural and Anatomical Determinants of Multielectrode Renal Denervation Efficacy.Tzafriri AR, Mahfoud F, Keating JH et al. Hypertension. 2019 Sep;74(3):546-554. doi: 10.1161/HYPERTENSIONAHA.119.12918
Pulmonary Artery Denervation Using Catheter based Ultrasonic Energy. Rothman A, Jonas M, Castel D, Tzafriri AR et al. EuroIntervention. 2019 May 7. pii: EIJ-D-18-01082. doi: 10.4244/EIJ-D-18-01082.
Anatomical and procedural determinants of ambulatory blood pressure lowering following catheter-based renal denervation using radiofrequency. Lauder L, Ewen S, Tzafriri AR et al. Cardiovasc Revasc Med. 2018 Oct - Nov;19(7 Pt B):845-851. doi: 10.1016/j.carrev.2018.02.016.
Renal artery anatomy assessed by quantitative analysis of selective renal artery in 1000 patients with hypertension. Lauder L, Ewen S, Tzafriri ARet al. EuroIntervention. 2018 May 20;14(1):121-128. doi: 10.4244/EIJ-D-18-00112.
Anatomical and procedural determinants of catheter-based renal denervation. S Ewen, C Ukena, T Luscher et al. Cardiovasc Revasc Med. 2016 Oct - Nov;17(7):474-479. doi: 10.1016/j.carrev.2016.08.004.
Renal sympathetic nerve denervation using intraluminal ultrasound within a cooling balloon preserves the arterial wall and reduces sympathetic nerve activity. Pathak A, Coleman L, Roth A et al. EuroIntervention. 2015 Aug 22;11(4):477-84.
Arterial microanatomy determines the success of energy-based renal denervation in controlling hypertension. Tzafriri AR, Keating JH, Markham PM et al. Science Translational Medicine. 2015 Apr 29;7(285):285ra65. doi: 10.1126/scitranslmed.aaa3236.
Renal denervation: Not as easy as it looks. Editorial in Science Translational Medicine by Murray Esler Baker IDI Heart and Diabetes Institute, Melbourne, Victoria, Australia.
Comparison of renal artery, soft tissue, and nerve damage after irrigated versus nonirrigated radiofrequency ablation. Sakakura K, Ladich E, Fuimaono K et al. Circulation: Cardiovascular Interventions. 2014 Dec 31;8(1). pii: e001720. doi: 10.1161.
Innervation patterns may limit response to endovascular renal denervation. Tzafriri AR, Mahfoud F, Keating JH et al. Journal of the American College of Cardiology. 2014 Sep 16;64(11):1079-87.
Methodological Standardization for the Pre-Clinical Evaluation of Renal Sympathetic Denervation. Sakakura K, Ladich E, Edelman ER et al. JACC Cardiovasc Interv. 2014 Sep 9.
Evaluation of renal nerve morphological changes and norepinephrine levels following treatment with novel bipolar radiofrequency delivery systems in a porcine model. Cohen-Mazor M, Mathur P, Stanley JR et al. J Hypertension. 2014 May 28
Recent CBSET scientific papers & presentations related to novel PAD therapies:
Balloon-based drug coating delivery to the artery wall is dictated by coating micro-morphology and angioplasty pressure gradients Abraham R. Tzafriri, Benny Muraj, Fernando Garcia-Polite, Antonio G. Salazar-Martín, Peter Markham, Brett Zani, Anna Spognardi, Mazen Albaghdadi, Steve Alston, Elazer R. Edelman. Biomaterials. 2020 Nov;260:120337.
Taking paclitaxel coated balloons to a higher level: Predicting coating dissolution kinetics, tissue retention and dosing dynamics. Abraham R.Tzafriri, Sahil A.Parikh, Elazer R.Edelman. Journal of Controlled Release. Volume 310, 28 September 2019, Pages 94-102.
Enhanced Plaque Modification of Cadaveric Human Calcified Peripheral Arteries Treated with a Vessel Preparation System. Video interview at CRT19. CBSET’s Director of Research and Innovation, Rami Tzafriri, PhD, discusses CBSET’s human cadaver model assessment of a vessel preparation system and the attributes of this particular technology that suggest it might be conducive to enhancing drug absorption.
Calcified plaque modification alters local drug delivery in the treatment of peripheral atherosclerosis. Abraham R. Tzafriri, Fernando Garcia-Polite, Brett Zani, James Stanley, Benny Muraj, Jennifer Knutson, Robert Kohler, Peter Markham, Alexander Nikanorov, Elazer R. Edelman, Journal of Controlled Release, Volume 264, 28 October 2017, Pages 203-210.
Evaluation of a novel paclitaxel coated intravascular balloon. Abraham R. Tzafriri, PhD. Presented at CX 2017 – The Charing Cross International Symposium, April 25-28, Kensington, London, UK.
Mechanisms Underlying Drug Delivery to Peripheral Arteries. Li J, Tzafriri R, Patel SM, Parikh SA. Interventional Cardiology Clinics. 2017 Apr;6(2):197-216. doi: 10.1016/j.iccl.2016.12.004.
Two Blades-Up Runs Using the JetStream Navitus Atherectomy Device Achieve Optimal Tissue Debulking of Nonocclusive In-Stent Restenosis: Observations From a Porcine Stent/Balloon Injury Model. Shammas NW, Aasen N, Bailey L, Budrewicz J, Farago T, Jarvis G. Journal of Endovascular Therapy. 2015 Aug;22(4):518-24.
Effects of Orbital Atherectomy Treatment on Drug Absorption in Calcified Peripheral Arteries. Elazer R. Edelman, MD. Presented at CRT15 – Cardiovascular Research Technologies (CRT); 2015 Feb 21-24; Washington, DC.
Mechanisms of Tissue Uptake and Retention in Zotarolimus-Coated Balloon Therapy. Vijaya B. Kolachalama, Stephen D. Pacetti, Joseph W. Franses, John J. Stankus, Hugh Q. Zhao, Tarek Shazly, Alexander Nikanorov, Lewis B. Schwartz, Abraham R. Tzafriri, Elazer R. Edelman. Circulation. 2013;127:2047-2055.
Correlative evaluation of variable pressure-scanning electron microscopy to histology methods for vascular tissues. P. Seifert, K. Regan, B.G. Zani, G. Wong, and J. Stanley. Journal of Histotechnology, 2013 March; 36 (1): 25-29.