Tag Archives: 2016

ICI 2016: Multiple drug coated balloon exposures increase arterial permeability and drug retention

Rami Tzafriri; Peter Markham; Brett Zani; Steve Alston; Elazer Edelman. ‘Multiple drug coated balloon exposures increase arterial permeability and drug retention.’ Presented at: Innovations in Cardiovascular Interventions (ICI), Dec 4-6, 2016, Tel Aviv, Israel. Summary: It is thought that increased dose or number of drug-coated balloon (DCB) inflations increases drug delivery and tissue retention – this […]

MDD: Pre-clinical studies of implantable medical devices: Lessons from the front lines

Peter Markham, MS and Rami Tzafriri, PhD. ‘Pre-clinical studies of implantable medical devices: Lessons from the front lines..’ Summary: Surveying three example cases of pre-clinical studies of combination medical devices, the presentation attempts to illustrate 3 key lessons: First follower – Don’t just follow first generation testing paradigm. Speed and differentiation are most important New product […]

TCT 2016: Multiple drug coated balloon exposures increase arterial permeability and drug retention

Rami Tzafriri; Brett Zani; Steve Alston; Elazer Edelman. ‘Multiple drug coated balloon exposures increase arterial permeability and drug retention.’ Poster presented at: Transcatheter Cardiovascular Therapeutics (TCT), Oct 25-Nov 2, 2016, Washington, DC. Summary: It is thought that increased dose or number of drug-coated balloon (DCB) inflations increases drug delivery and tissue retention – this however has […]

Press Release: CBSET appoints Rami Tzafriri PhD as Director of Research and Innovation

LEXINGTON, Mass., Oct 28, 2016 — CBSET Inc. announced today that it has appointed Dr. Rami Tzafriri as Director of Research and Innovation. Since 2009, Dr. Tzafriri has held the position of Principal Scientist at CBSET, where he developed quantitative computational and experimental methods for evaluating combination drug and energy delivery devices. He is best known […]

Press Release: CBSET appoints Michael Naimark as Director of Business Development

LEXINGTON, Mass., Oct 27, 2016 — CBSET, Inc. announced today that it has appointed Michael Naimark as Director of Business Development, effective immediately. Most recently, he was employed by the Neural Stem Cell Institute (NSCI) as project manager overseeing the development of a cell-based therapy for macular degeneration under a 4-year award from the New York Stem […]

Cardiovascular Revascularization Medicine: Anatomical and Procedural Determinants of Catheter-based Renal Denervation

S Ewen; C Ukena; T Luscher; M Bergmann; P Blankestijn; B Cremers; E Blessing; O Doerr; H Nef; M Schlaich; F Sharif; MVoskuil; T Zeller; AR Tzafriri; E Edelman; Ml Boehm; FMahfoud. Anatomical and procedural determinants of catheter-based renal denervation Summary: Catheter-based renal sympathetic denervation (RDN) can reduce blood pressure (BP) and sympathetic activity in certain […]

SNIS: Preclinical Evaluation of Mechanical Thrombectomy Devices in a Swine Clot Model

L Bailey, AS; M Gilvarry; M Holian; R Tzafriri, PhD, J Keating, DVM, DACVP, E Edelman, MD, PhD, FACC. ‘Preclinical Evaluation of Mechanical Thrombectomy Devices in a Swine Clot Model.’ Summary: Successful recanalization (TICI ≥2b) using mechanical thrombectomy (MT) with stent retriever devices is associated with good outcomes in the treatment of ischemic stroke. Preclinical TICI […]

News Advisory: You Need To Know: Endovascular Drug Delivery Is Experiencing a Resurgence in Innovation

“Understanding and computationally modeling the determinants of drug release kinetics and tissue distribution can help further drive innovation at reduced cost.” – Rami Tzafriri, PhD, Principal Scientist, CBSET “Endovascular Drug Delivery and Drug Elution Systems: First Principles” Abraham Rami Tzafriri, PhD Elazer Reuven Edelman, MD, PhD “…The first principles outlined…serve as a handbook for features […]