Goffer, Efrat M.; Lamberti, Kimberly K.; Spognardi, Anna-Maria; Edelman, Elazer R.; Keller, Steven P. Steady Flow Left Ventricle Unloading Is Superior to Pulsatile Pressure Augmentation Venting During Venoarterial Extracorporeal Membrane Oxygenation Support Abstract Venoarterial extracorporeal membrane oxygenation (VA-ECMO) shunts venous blood to the systemic arterial circulation to provide end-organ perfusion while increasing afterload that may […]
Kimberly K. Lamberti, Steven P. Keller, Elazer R. Edelman. Dynamic load modulation predicts right heart tolerance of left ventricular cardiovascular assist in a porcine model of cardiogenic shock. Ventricular assist devices (VADs) offer mechanical support for patients with cardiogenic shock by unloading the impaired ventricle and increasing cardiac outflow and subsequent tissue perfusion. Their ability […]
Aron B. Fisher, Brett Zani, Thomas Han, Chandra Dodia, Raffaele Melidone, Steven Keller. Decreased LPS-induced lung injury in pigs treated with a lung surfactant protein A-derived nonapeptide that inhibits peroxiredoxin 6 activity. This study addressed the efficacy of a liposome-encapsulated 9 amino acid peptide (PIP-2) for the prevention or treatment of acute lung injury (ALI) […]
Linnea Tscheuschner, Abraham R. Tzafriri. Cardiovascular Tissue Engineering Models for Atherosclerosis Treatment Development. In the early years of tissue engineering, scientists focused on the generation of healthy-like tissues and organs to replace diseased tissue areas with the aim of filling the gap between organ demands and actual organ donations. Over time, the realization has set […]
Stratakos E, Antonini L, Poletti G, Berti F, Tzafriri AR, Petrini L, Pennati G. Investigating Balloon-Vessel Contact Pressure Patterns in Angioplasty: In Silico Insights for Drug-Coated Balloons. Drug-coated balloons have shown promising results as a minimally invasive approach to treat stenotic arteries, but recent animal studies have revealed limited, non-uniform coating transfer onto the arterial […]
Helge Struthoff, Lucas Lauder, Mathias Hohl, Alexander Hermens, Abraham Rami Tzafriri, Elazer R Edelman, Michael Kunz, Michael Böhm, Thomas Tschernig, Felix Mahfoud. “Histological examination of renal nerve distribution, density, and function in humans” Background: Renal denervation is optimised when guided by knowledge of nerve distribution. Aims: We aimed to assess sympathetic nerve distribution along the […]
Sumati Sundaram, Karissa L. Paquin, Tina Roffidal, Greg Booker, Sherif Soliman, Jeff Bouchard, Elisaveta Todorova, Brett G. Zani, Raffaele Melidone, Saverio La Francesca, and William Fodor. “Early tissue growth and cell fate determination following segmental esophageal repair using a tissue engineered esophageal implant composed of a polyurethane scaffold seeded with autologous adipose-derived mesenchymal stromal cells.” […]
Lisa Spirio, Eun Seok Gil, Kate O’neill, Elton Aleksi, Jay Budrewicz, and Raffaele Melidone. “Comparison of PuraStat self-assembling peptide hydrogel versus mineral-based Hemospray for endoscopic hemostasis of upper and lower gastrointestinal lesions in pigs.” Objective: To compare a RADA16-based self-assembling peptide hydrogel versus an inorganic powder-based spray device for controlling postoperative bleeding in upper and […]
Christina Kottooran, Jeffrey Twum-Ampofo, Jason Lee, Jennifer Saunders, Marle Franco, Jay Budrewicz, Brian H Eisner. “Evaluation of fluid absorption during flexible ureteroscopy in an in vivo porcine model.” Objective: The purpose of this study was to evaluate the relationship between renal pelvis pressure and fluid absorption during ureteroscopy in a live porcine model. Materials and […]
Abraham Rami Tzafriri PhD, Fernando Garcia-Polite PhD, John Keating DVM DACVP, Raffaele Melidone DVM DACVP, Jennifer Knutson BS, Peter Markham MS, Elazer R. Edelman MD PhD, Felix Mahfoud MD. “Morphometric analysis of the human common hepatic artery (CHA) reveals a rich and accessible target for sympathetic liver denervation.” FULL ARTICLE Summary: Treatment of type 2 […]