Misty J. Williams-Fritze, Benny Muraj, Amanda McSweeney, Fernando Garcia-Polite, Raffaele Melidone, Jonathon Kirk, Rami Tzafriri , Cyrille Sage. Cochlear Implant: Mini Swine or Sheep? Such a Tricky Choice. Background: Cochlear implants (CI) are a growing market currently valued at $1.67 billion and projected to grow 10.6%/year from 2020 to 2027 (Figure 1). Since the first […]
Rami Tzafriri, Jay Budrewicz, Lynn Bailey, Peter Markham, Maxen Albaghdadi, Elazer Edelman. Lesion Modification with a Micro-Incision Vessel Preparation System Enhances Balloon-Based Drug Delivery in Complex Porcine Restenotic Lesions. Live presentation abstract: This study examined if and how a vessel preparation system delivering micro-incisions could enhance in vivo paclitaxel (delivered from a DCB) retention in […]
Abraham Tzafriri , Benny Muraj , Fernando Gacia-Polite , Antonio-Gabino Salazar-Martin , Peter Markham , Anna-Maria Spognardi , Brett Zani , Mazen Albaghdadi , Steve Alston , and Elazer Edelman. “Drug-Coated Balloon Contact Pressure Predicts Endoluminal Coating Distribution.” Background: Paclitaxel-coated balloons (PCBs) control iliofemoral atherosclerotic lesions, yet restenosis rates remain hight without calss effect. We […]
Kevin Wood, Jay Budrewicz, Moises Rivera Bermudez, Katrina Hansen. “A novel modified jejunum model for endoscopic ultrasonography-guided biliary drainage procedures.” Summary: There are a host of disease pathologies within the biliary anatomy that manifest in luminal obstruction and consequential dilation. An Endoscopic Retrograde Cholangiopancreotography (ERCP)-guided biliary drainage procedure is used as the primary approach to […]
Abraham R.Tzafriri, Farhad Rikhtegar Nezami, Elazer R.Edelman. ‘Computational Prediction Of Drug-eluting Stent Performance In Patient-specific Arteries – A Virtual Reality.’ Poster presentation at: CRT 2020, Feb 22-25; National Harbor, MD. Summary: Computational modeling is revolutionizing device design and evaluation. While great progress has been made in virtual stent angioplasty and computational hemodynamics, drug-delivery modeling in patient-specific geometries remains […]
Abraham R.Tzafriri, AnnaMariaSpognardi, LynnBailey, JohnKeating, PeterMarkham, GaryBinyamin, MariaPizarro, EitanKonstantino, Elazer R.Edelman. ‘Six Month Safety Evaluation Of The Chocolate Touch™ Drug-coated Balloon Catheter In The Swine Peripheral Artery Model.’ Presented at: CRT 2020, Feb 22-25; National Harbor, MD. Summary: We evaluated the preclinical safety of a novel paclitaxel-coated balloon catheter (PCB) with a nitinol constraining structure positioned over it, […]
Abraham R.Tzafriri. ‘Procedural and Anatomical Determinants of Multi-Electrode Renal Denervation: Preclinical Versus Clinical.’ Summary: The failure of the prospective, randomized, sham-controlled SYMPLICITY HTN-3 trial to show significant difference in reduction of systolic BP (SBP) in patients with resistant hypertension 6 months after RDN compared to controls was attributed in part to procedural limitations in first generation […]
Farhad Rikhtegar Nezami, Abraham R. Tzafriri, Elazer R.Edelman. ‘Transient subject-specific drug delivery in stented arteries: physics-based simulation of controlled release and retention.’ Summary: Drug-eluting stents are the mainstay therapy for obstructive arterial disease, yet further innovation is hampered by cost and lack of experimental techniques. In silico models, akin to what developed here, offer flexible and […]
Suchi Raghunathan, Randolph Abutin, Amanda McSweeney, Misty J. Williams-Fritze, Rami Tzafriri, Cyrille Sage. ‘Large Animal Models for Auditory Research: Guide to the Perplexed.’ Poster presentation at: ARO Midwinter Meeting, Jan 25-29, 2020, San Jose, CA. Summary: Auditory studies, including those evaluating ototoxicity and pharmacokinetics (PK), are typically performed using rodent models. Some studies, however, may require a […]
Tzafriri AR. “Multiyear Tissue Retention of Paclitaxel is Driven by Lesion Complexity: Insights from Experimentally Grounded Computational Modeling“ A recent meta-analysis of randomized controlled trials investigating paclitaxel-coated balloons and stents in femoropopliteal arteries reported increased mortality risk 2-5 years after treatment, with no causal mechanism. We developed an experimentally grounded computational model to identify scenarios […]