“One Month Preclinical Safety and Efficacy Evaluation of a Yttrium-90 Resin Microsphere Glue Formulation in the Oncopig® Pancreatic Cancer Model.” Kyle M. Schachtschneider, Felicia Bealo, Pietro Bubba Bello, Pieter Janssen, Misty J. Williams-Fritze, Rami Tzafriri, Daniel Blanco, Gianluca De Danieli, Govindarajan Narayanan Purpose: Pancreatic cancer is a major health problem worldwide, representing the fourth-leading cause […]
This webinar explores the growing importance of auditory safety testing in the development of new therapeutics. This session is designed for researchers, toxicologists, and regulatory professionals seeking to better understand and implement auditory safety strategies from discovery through clinical development. The session was presented by CBSET Study Director Donald Hodges, MSc, PhD, DSP, DABT, and […]
Comparative Pharmacokinetics Study of Four Commercial Formulations of Buprenorphine in Yorkshire swine (Sus scrofa domesticus). SM Ganesan, R Tzafriri, PA Lester, P Markham, M Williams-Fritze Opioids are commonly utilized for controlling pain in humans and animals. Specifically, buprenorphine has been shown to provide excellent post-operative analgesia in laboratory species. However, limited pharmacokinetic data are available […]
The Pig Behind the Mask: Creation of an Anesthesia Mask to Fit Big Pigs. Melissa Davis, AS, LATg; Alexandria Moen, BS, RLATg; and Misty Williams-Fritze, DVM, MS, DALCAM. Gas anesthetics are safe, effective, short acting agents frequently administered to swine. Typically, gas (either isoflurane or sevoflurane) is administered in combination with oxygen through a vaporizer and […]
How low can you go? Using bottle volume as an alternative to time-scheduled water bottle replacements for mice. Alyssa L. Valentyn, Venus Estrada, Naina Silva, Misty Williams-Fritze, Laurette Burgess. The use of sterile disposable cage components has led to an increased need for performance-based standards. The Guide specifies that sipper tubes require weekly sanitization. However, […]
Rami Tsafriri, CBSET’s Director of Research and Innovation, at the 31st Annual Meeting of the Japanese Society for Endovascular Therapy (JSEI) with Drs. Takao Ohki and Terry Hasebe, respectively, the founding and current Presidents of JSEI. Keynote presentation, 31st Annual Meeting of the Japan Society of Endovascular Therapy (JSEI), June 13-14, Okinawa, Japan
“Preclinical study of safety and efficacy in vivo of a yttrium-90 resin microspheres glue formulation in a large animal model of pancreatic cancer” N Govindarajan Sr., JeGeschwind, F Bealo, P Janssen, PB Bello, G De Danieli. Background: Pancreatic ductal adenocarcinoma (PDAC), the most common cancer type in the pancreas, constitutes a major health problem worldwide […]
“Stenosis limited release from drug coated balloons and local delivery to peripheral porcine arteries.” Rami Tzafriri, Peter Markham, Benny Muraj, Jay Budrewicz, Anna-Maria Spognardi Aims: The influence of lesion complexity on drug release and tissue delivery by drug coated balloons (DCB) cannot be studied clinically and has not been systematically studied in animal models. The […]
“Anatomic guidance to sympathetic denervation of the common hepatic artery.” Rami Tzafriri, Fernando Garcia-Polite, John Keating, Raffaele Melidone, Jennifer Knutson, Peter Markham, Elazer R. Edelman, Felix Mahfoud. Aims: Combined renal artery and common hepatic artery (CHA) denervation is being explored as a novel therapy for uncontrolled hypertension. As guidance for clinical studies, we quantified the […]
“Preclinical safety and efficacy of a novel extravascular bi-lateral renal denervation instrument.” Rami Tzafriri, Peter Markham, Misty Williams-Fritze, John Keating, Jay Budrewicz, Chang-Wook Jeong Aims: Intravascular catheter-based renal denervation (RDN) is limited to accessible renal arteries (≥3mm). The aim of this study was to preclinically evaluate the chronic safety of a novel extravascular radiofrequency (RF) […]