AR Tzafriri, A-M Spognardi, J Budrewicz, B Muraj, P Markham. ‘Stenosis Limited Local Paclitaxel Release and Arterial Delivery From Paclitaxel Coated Balloons in a Porcine Peripheral Instent Restenosis Model.’ Presented at: CRT 2026. Background: We examined whether instent restenosis lesions (ISRL) can limit drug release and arterial delivery by paclitaxel coated balloon (PCB) in porcine superficial […]
AR Tzafriri, A-M Spognardi, P Markham, JH Keating, MW Kayo, S Karamdoust, A Pollit, A Raval, R Mandal. ‘Mechanistic Kinetic Modeling Of Polymer Bioresorption Can Derisk The Preclinical Safety Evaluation Of Bioresorbable Polymer Coated Stents.’ Presented at: CRT 2026. Background: Slow bioresorbing polymeric stent coatings reduce tissue exposure to potentially proinflammatory erosion by-products, yet necessitate preclinical […]
AR Tzafriri, A-M Spognardi, JH Keating, MW Kayo, R Mandal. ‘Chronic Preclinical Safety And Efficacy Of The Supraflex Cruz Sirolimus Eluting Stent In The Swine Coronary Artery Model.’ Presented at: CRT 2026. Background: We evaluated the preclinical safety of a coronary sirolimus eluting stent with an ultrathin strut and a bioresorbable polymer coating. Methods: Stents coated […]
“Bridging the Translational Valley of Death in Auditory Gene and Drug Therapies.” Donald Hodges, Ellie Khadir, Aurore Marie, Marie-Pierre Pasdelou, Gaelle Naert, Rami Tzafriri Background: Each year, exciting scientific discoveries are presented at ARO and yet the number of hearing therapies can be counted on one hand. High failure rates are common to all therapy […]
“ARO: The Sound of Safety: Why Glp Ototoxicity Testing Must Be Standard.” Ellie Khadir, Gaëlle Naert, Marie-Pierre Pasdelou, Aurore Marie, Rami Tzafriri, Donald Hodges Background: Hearing loss affects approximately 1.5 billion people worldwide, with ototoxicity representing a leading cause of acquired hearing loss globally. The number of ototoxic drugs is estimated between 150-600, with over […]
“Inner Ear Drug Delivery Route Selection: A Cross-Species Translation Framework.” Sébastien Diot, Molly Kalker, Marion Souchal, Carolanne Coyat, Aurore Marie, Elodie Flaszka, Véronique Baudoux, Camille Dejean, Sylvie Pucheu, Gaëlle Naert, Benny Muraj, Ellie Khadir, Donald Hodges, Rami Tzafriri, Misty J Williams-Fritze. Background: Gene or cell therapy targeting inner ear represents a challenge due to the […]
“One Month Preclinical Safety and Efficacy Evaluation of a Yttrium-90 Resin Microsphere Glue Formulation in the Oncopig® Pancreatic Cancer Model.” Kyle M. Schachtschneider, Felicia Bealo, Pietro Bubba Bello, Pieter Janssen, Misty J. Williams-Fritze, Rami Tzafriri, Daniel Blanco, Gianluca De Danieli, Govindarajan Narayanan Purpose: Pancreatic cancer is a major health problem worldwide, representing the fourth-leading cause […]
This webinar explores the growing importance of auditory safety testing in the development of new therapeutics. This session is designed for researchers, toxicologists, and regulatory professionals seeking to better understand and implement auditory safety strategies from discovery through clinical development. The session was presented by CBSET Study Director Donald Hodges, MSc, PhD, DSP, DABT, and […]
Comparative Pharmacokinetics Study of Four Commercial Formulations of Buprenorphine in Yorkshire swine (Sus scrofa domesticus). SM Ganesan, R Tzafriri, PA Lester, P Markham, M Williams-Fritze Opioids are commonly utilized for controlling pain in humans and animals. Specifically, buprenorphine has been shown to provide excellent post-operative analgesia in laboratory species. However, limited pharmacokinetic data are available […]
The Pig Behind the Mask: Creation of an Anesthesia Mask to Fit Big Pigs. Melissa Davis, AS, LATg; Alexandria Moen, BS, RLATg; and Misty Williams-Fritze, DVM, MS, DALCAM. Gas anesthetics are safe, effective, short acting agents frequently administered to swine. Typically, gas (either isoflurane or sevoflurane) is administered in combination with oxygen through a vaporizer and […]