Tzafriri R, Spognardi AM, Markham P, Kayo M, Keating J, Karamdoust S, Pollit A, Raval A, Mandal R. ‘Preclinical Safety Evaluation and Computational Modeling Of Bioresorbable Polymer Coated Stents.’ E-poster at EuroPCR 2026. AIMS: Slowing the bioresorption of polymeric stent coatings can reduce tissue exposure to potentially proinflammatory erosion by-products, yet the requirements of preclinical evaluation […]
Tzafriri R, Bealo F, Spognardi AM, Rickman B, Markham P, Bedoya M, Wilkirson E, Schwartz R. ‘Preclinical feasibility of combined denervation of the celiac, common hepatic and splenic arteries.’ E-poster at EuroPCR 2026. AIMS: Given its role as a conduit for transmitting visceral pain signals from the abdominal organs to the central nervous system, neurolytic blockade […]
Khadir E, Burns J, Palermo A, Budrewicz J, Mota J, Horn M, Tzafriri AR. ‘Seroprevalence of AAV8 Neutralizing Antibodies in Domestic Swine: Implications for Preclinical Gene Therapy Studies.’ Presented at ASGCT 2026. Introduction: Adeno-associated virus serotype 8 (AAV8) is widely used in gene therapy for its superior hepatic tropism and efficient muscle transduction. Pre-existing neutralizing […]
Cathal Flood, Nikita R. Bhatt, Jay Budrewicz, Barry Rickman, Michael Walsh, Hugh Flood, and Niall Davis. IP10-26: ‘Further Validation of the Transurethral Catheterization Safety Valve (TUCSV) Pressure Threshold in a Porcine Model.’ Presented at: the American Urological Association meeting, AUA 2026. ABSTRACT: Inadvertent inflation of a catheter anchoring ballon in the urethra can cause urethral rupture […]
AR Tzafriri, A-M Spognardi, J Budrewicz, B Muraj, P Markham. ‘Stenosis Limited Local Paclitaxel Release and Arterial Delivery From Paclitaxel Coated Balloons in a Porcine Peripheral Instent Restenosis Model.’ Presented at: CRT 2026. Background: We examined whether instent restenosis lesions (ISRL) can limit drug release and arterial delivery by paclitaxel coated balloon (PCB) in porcine superficial […]
AR Tzafriri, A-M Spognardi, P Markham, JH Keating, MW Kayo, S Karamdoust, A Pollit, A Raval, R Mandal. ‘Mechanistic Kinetic Modeling Of Polymer Bioresorption Can Derisk The Preclinical Safety Evaluation Of Bioresorbable Polymer Coated Stents.’ Presented at: CRT 2026. Background: Slow bioresorbing polymeric stent coatings reduce tissue exposure to potentially proinflammatory erosion by-products, yet necessitate preclinical […]
AR Tzafriri, A-M Spognardi, JH Keating, MW Kayo, R Mandal. ‘Chronic Preclinical Safety And Efficacy Of The Supraflex Cruz Sirolimus Eluting Stent In The Swine Coronary Artery Model.’ Presented at: CRT 2026. Background: We evaluated the preclinical safety of a coronary sirolimus eluting stent with an ultrathin strut and a bioresorbable polymer coating. Methods: Stents coated […]
“Bridging the Translational Valley of Death in Auditory Gene and Drug Therapies.” Donald Hodges, Ellie Khadir, Aurore Marie, Marie-Pierre Pasdelou, Gaelle Naert, Rami Tzafriri Background: Each year, exciting scientific discoveries are presented at ARO and yet the number of hearing therapies can be counted on one hand. High failure rates are common to all therapy […]
“ARO: The Sound of Safety: Why Glp Ototoxicity Testing Must Be Standard.” Ellie Khadir, Gaëlle Naert, Marie-Pierre Pasdelou, Aurore Marie, Rami Tzafriri, Donald Hodges Background: Hearing loss affects approximately 1.5 billion people worldwide, with ototoxicity representing a leading cause of acquired hearing loss globally. The number of ototoxic drugs is estimated between 150-600, with over […]
“Inner Ear Drug Delivery Route Selection: A Cross-Species Translation Framework.” Sébastien Diot, Molly Kalker, Marion Souchal, Carolanne Coyat, Aurore Marie, Elodie Flaszka, Véronique Baudoux, Camille Dejean, Sylvie Pucheu, Gaëlle Naert, Benny Muraj, Ellie Khadir, Donald Hodges, Rami Tzafriri, Misty J Williams-Fritze. Background: Gene or cell therapy targeting inner ear represents a challenge due to the […]