Rami Tsafriri, CBSET’s Director of Research and Innovation, at the 31st Annual Meeting of the Japanese Society for Endovascular Therapy (JSEI) with Drs. Takao Ohki and Terry Hasebe, respectively, the founding and current Presidents of JSEI. Keynote presentation, 31st Annual Meeting of the Japan Society of Endovascular Therapy (JSEI), June 13-14, Okinawa, Japan
“Preclinical study of safety and efficacy in vivo of a yttrium-90 resin microspheres glue formulation in a large animal model of pancreatic cancer” N Govindarajan Sr., JeGeschwind, F Bealo, P Janssen, PB Bello, G De Danieli. Background: Pancreatic ductal adenocarcinoma (PDAC), the most common cancer type in the pancreas, constitutes a major health problem worldwide […]
“Stenosis limited release from drug coated balloons and local delivery to peripheral porcine arteries.” Rami Tzafriri, Peter Markham, Benny Muraj, Jay Budrewicz, Anna-Maria Spognardi Aims: The influence of lesion complexity on drug release and tissue delivery by drug coated balloons (DCB) cannot be studied clinically and has not been systematically studied in animal models. The […]
“Anatomic guidance to sympathetic denervation of the common hepatic artery.” Rami Tzafriri, Fernando Garcia-Polite, John Keating, Raffaele Melidone, Jennifer Knutson, Peter Markham, Elazer R. Edelman, Felix Mahfoud. Aims: Combined renal artery and common hepatic artery (CHA) denervation is being explored as a novel therapy for uncontrolled hypertension. As guidance for clinical studies, we quantified the […]
“Preclinical safety and efficacy of a novel extravascular bi-lateral renal denervation instrument.” Rami Tzafriri, Peter Markham, Misty Williams-Fritze, John Keating, Jay Budrewicz, Chang-Wook Jeong Aims: Intravascular catheter-based renal denervation (RDN) is limited to accessible renal arteries (≥3mm). The aim of this study was to preclinically evaluate the chronic safety of a novel extravascular radiofrequency (RF) […]
The Pig Behind the Mask: Creation of an Anesthesia Mask to Fit Big Pigs. Melissa Davis, AS, LATg; Alexandria Moen, BS, RLATg; and Misty Williams-Fritze, DVM, MS, DALCAM. Gas anesthetics are safe, effective, short acting agents frequently administered to swine. Typically, gas (either isoflurane or sevoflurane) is administered in combination with oxygen through a vaporizer […]
“Intracochlear administration methods across species.” Molly Kalker, Benny Muraj, Marion Souchal, Ellie Khadir, Gaëlle Naert, Aurore Marie, Donald Hodges, Rami Tzafriri, Sebastien Diot Inner ear delivery offers several advantages for gene therapy, including reduced viral titers, non-systemic administration, and improved transduction efficiency. Delivery can be performed via the round window (RW), posterior semi-circular canal (PSCC), […]
Use of esophageal balloon dilation to repair gastroesophageal stricture in a Yorkshire pig. Lisa Clarey, DVM, CPIA; Anna Spognardi, BA; Jay Budrewicz, ScM, LATg, SRT; Misty Williams-Fritze, DVM, MS, DACLAM Gastric ulcers are a common problem in commercial swine production, with reported prevalence rates ranging from 32 to 65% in finisher pigs. Pigs with active […]
CWJeong, J Budrewicz, JH Keating, M Williams-Fritze, P Markham, AR Tzafriri. ‘Twenty Four Week Safety and Efficacy of a Novel Extravascular Renal Denervation Device in a Porcine Model at an Elevated Temperature Setting.’ Presented at: CRT 2025. Background: Extravascular radiofrequency (RF) renal denervation (RDN) of pigs at nominal dose (50oC/70sec) using a device that circumferentially wraps […]
CWJeong, J Budrewicz, JH Keating, M Williams-Fritze, P Markham, AR Tzafriri. ‘Twenty Four Week Safety and Efficacy of a Novel Extravascular Renal Denervation Device in a Porcine Model at an Elevated Temperature Setting.’ Background: Extravascular radiofrequency (RF) renal denervation (RDN) of pigs at nominal dose (50oC/70sec) using a device that circumferentially wraps the renal artery […]