K Nakamura, MD; JH Keating, DVM; ER Edelman, MD, PhD. Pathology of Endovascular Stents. Summary: Coronary artery disease (CAD) represents the leading cause of death worldwide, attributed to more than 17.5 million deaths annually, accounting for approximately 1 of every 3 deaths. In the United States, contemporary decreases in CAD-related mortality correlate with the 2 decades after the Surgeon General report […]
Tag Archives: 2016
Interventional Cardiology Clinics: Endovascular Drug Delivery and Drug Elution Systems: First Principles
AR Tzafriri, PhD; ER Edelman, MD, PhD. Endovascular Drug Delivery and Drug Elution Systems: First Principles. Summary: Endovascular drug delivery continues to revolutionize the treatment of atherosclerosis in coronary and peripheral vasculature. The key has been to identify biological agents that can counter the hyperplastic tissue responses to device expansion/implantation and to develop effective local delivery […]
Ann Biomed Eng: Vascular Response to Experimental Stent Malapposition and Under-Expansion
O’Brien CC, Lopes AC, Kolandaivelu K, Kunio M, Brown J, Kolachalama VB, Conway C, Bailey L, Markham P, Costa M, Ware J, Edelman ER. Vascular Response to Experimental Stent Malapposition and Under-Expansion. Summary: Up to 80% of all endovascular stents have malapposed struts, and while some impose catastrophic events others are inconsequential. Thirteen stents were implanted […]
Biomaterials: A tunable delivery platform to provide local chemotherapy for pancreatic ductal adenocarcinoma.
Indolfi L, Ligorio M, Ting DT, Xega K, Tzafriri AR, Bersani F, Aceto N, Thapar V, Fuchs BC, Deshpande V, Baker AB, Ferrone CR, Haber DA, Langer R, Clark JW, Edelman ER. A tunable delivery platform to provide local chemotherapy for pancreatic ductal adenocarcinoma. Summary: Pancreatic ductal adenocarcinoma (PDAC) is one of the most devastating and […]
EuroPCR: Solubility-controlled sirolimus release from drug-filled stents
Tzafriri A, Garcia-polite F, Schulz-jander D, Melder R, Goshgarian J, Tunev S, Stone G, Edelman E. ‘Solubility-controlled sirolimus release from drug-filled stents.’ Summary: Whereas drug diffusion is typically the rate-limiting release mechanism observed in other polymer-coated drug-eluting stents (DES), drug release from prototype DFS is determined by a complex dissolution-precipitation mechanism sensitive to the equilibrium solubility […]
EuroPCR: Plaque modification with an orbital atherectomy system enhances drug distribution in calcified peripheral arteries
Tzafriri A., Nikanorov A., Zani B., Stanley J., Garcia-polite F., Budrewicz J., Knutson J., Kohler R., Markham P., Edelman E. ‘Plaque modification with an orbital atherectomy system enhances drug distribution in calcified peripheral arteries.’ Summary: Calcific atherosclerosis is a major challenge to intraluminal drug delivery treatments in peripheral artery disease. We evaluated the effects of […]
EuroPCR: ePTFE Balloon with a Paclitaxel-Coating Engineered for Enhanced Arterial Retention
Tzafriri A, Zani B, Spognardi, A, Bailey L, Alston S, Markham P. ‘ePTFE Balloon with a Paclitaxel-Coating Engineered for Enhanced Arterial Retention.’ Presentation at: EuroPCR; 2016 May 17-20; Paris, France.
Charing Cross: ePTFE balloon with a paclitaxel coating engineered for enhanced arterial retention: results with porcine peripheral arteries
Tzafriri AR. ‘ePTFE balloon with a paclitaxel coating engineered for enhanced arterial retention: results with porcine peripheral arteries.’ Podium presentation at : Charing Cross (CX); 2016 Apr 27; London, United Kingdom.
American College of Cardiologists: Anatomical and Procedural Determinants of Catheter-based Renal Denervation
S Ewen; C Ukena; T Luscher; M Bergmann; P Blankestijn; B Cremers; E Blessing; O Doerr; H Nef; M Schlaich; F Sharif; MVoskuil; T Zeller; AR Tzafriri; E Edelman; Ml Boehm; FMahfoud. Anatomical and Procedural Determinants of Catheter-based Renal Denervation Summary: Catheter-based renal sympathetic denervation (RDN) can reduce blood pressure (BP) and sympathetic activity in certain […]
Society of Toxicology: Safety Assessment of Radiofrequency Renal Denervation in Swine
Keating JH, Stanley JRL, Tzafriri AR, Spognardi AM, Markham PM, Edelman ER. ‘Safety Assessment of Radiofrequency Renal Denervation in Swine.’ Summary: Radiofrequency (RF) renal denervation (RDN) is a novel catheter based treatment option for patients with refractory hypertension, wherein energy is delivered at the renal artery wall lumen by a single or multiple RF electrodes. Efficacious […]