Tzafriri, A.R. and E.R. Edelman. Endosomal receptor kinetics determine the stability of intracellular growth factor signalling complexes. Summary: There is an emerging paradigm that growth factor signalling continues in the endosome and that cell response to a growth factor is defined by the integration of cell surface and endosomal events. As activated receptors in the endosome […]
Category Archives: Publications
Circulation: Differential Response to Vascular Stenting in Control Vs Insulin-Treated Diabetic Pigs: Analysis of Carotid, Renal and Coronary Bare Metal Stents (BMS) and Coronary Sirolimus Eluting Stents (SES)
Jonas M, Edelman ER, Baker AB, Spognardi AM, Groothuis A, Seifert P, Rogers C. Differential Response to Vascular Stenting in Control Vs Insulin-Treated Diabetic Pigs: Analysis of Carotid, Renal and Coronary Bare Metal Stents (BMS) and Coronary Sirolimus Eluting Stents (SES). Circulation 2006; 114:II_392.
Circ Res: Vascular neointimal formation and signaling pathway activation in response to stent injury in insulin-resistant and diabetic animals
M Jonas M, Edelman ER, Groothuis A, Baker AB, Seifert P, Rogers C. Vascular neointimal formation and signaling pathway activation in response to stent injury in insulin-resistant and diabetic animals. Summary: Diabetes and insulin resistance are associated with increased disease risk and poor outcomes from cardiovascular interventions. Even drug-eluting stents exhibit reduced efficacy in patients […]
Journal of Controlled Release: Local and systematic drug competition in drug-eluting stent tissue deposition properties
Levin AD, Jonas M, Hwang CW, Edelman ER. Local and systematic drug competition in drug-eluting stent tissue deposition properties. Summary: The efficacy of drug-eluting stents (DES) requires delivery of potent compounds directly to the underlying arterial tissue. The commercially available DES drugs rapamycin and paclitaxel bind specifically to their respective therapeutic targets, FKBP12 and polymerized microtubules, […]
Circulation: Strut position, blood flow, and drug deposition: implications for single and overlapping drug-eluting stents
Balakrishnan B, Tzafriri AR, Seifert P, Groothuis A, Rogers C, Edelman ER. Strut position, blood flow, and drug deposition: implications for single and overlapping drug-eluting stents. Summary: The intricacies of stent design, local pharmacology, tissue biology, and rheology preclude an intuitive understanding of drug distribution and deposition from drug-eluting stents (DES). Circulation 2005 Jun 7;111(22):2958-65.
Circulation: Thrombosis modulates arterial drug distribution for drug-eluting stents
Hwang CW, Levin AD, Jonas M, Li PH, Edelman ER. Thrombosis modulates arterial drug distribution for drug-eluting stents. Summary: Drug-eluting stents deliver potent compounds directly to arterial segments but can become clot laden when deployed. The question arises as to whether thrombi affect drug elution and arterial uptake. Circulation 2005 Apr 5;111(13):1619-26.
Clinical Cancer Research: Mathematical modeling and optimization of drug delivery from intratumorally injected microspheres
Tzafriri AR et al. Mathematical modeling and optimization of drug delivery from intratumorally injected microspheres. Summary: Paclitaxel is a highly promising phase-sensitive antitumor drug that could conceivably be improved by extended lower dosing as opposed to intermittent higher dosing. Although intratumoral delivery of paclitaxel to the whole tumor at different loads and rates has already been […]
J Theor Biol: Analysis of compartmental models of ligand-induced endocytosis
Tzafriri, A.R., D. Wu, and E.R. Edelman. Analysis of compartmental models of ligand-induced endocytosis. Summary: Kinetic models have played a pivotal role in the study of ligand-induced endocytosis. However, an analysis that suggests a systematic way to validate such models is lacking. The current work analyses the base model of ligand-induced endocytosis for three widely used […]
PNAS: Specific binding to intracellular proteins determines arterial transport properties for rapamycin and paclitaxel
Levin AD, Vukmirovic N, Hwang CW, Edelman ER. Specific binding to intracellular proteins determines arterial transport properties for rapamycin and paclitaxel. Summary: Endovascular drug-eluting stents have changed the practice of medicine, and yet it is unclear how they so dramatically reduce restenosis and how to distinguish between the different formulations available. Biological drug potency is not […]
Circulation: Liposomal Alendronate Inhibits Systemic Innate Immunity and Reduces In-Stent Neointimal Hyperplasia in Rabbits
Danenberg HD, Golomb G, Groothuis A, Gao J, Epstein H, Swaminathan RV, Seifert P, Edelman ER. Liposomal Alendronate Inhibits Systemic Innate Immunity and Reduces In-Stent Neointimal Hyperplasia in Rabbits. Summary: Innate immunity is of major importance in vascular repair. The present study evaluated whether systemic and transient depletion of monocytes and macrophages with liposome-encapsulated bisphosphonates inhibits experimental […]