Category Archives: Presentations

ICI 2016: Multiple drug coated balloon exposures increase arterial permeability and drug retention

Rami Tzafriri; Peter Markham; Brett Zani; Steve Alston; Elazer Edelman. ‘Multiple drug coated balloon exposures increase arterial permeability and drug retention.’ Presented at: Innovations in Cardiovascular Interventions (ICI), Dec 4-6, 2016, Tel Aviv, Israel. Summary: It is thought that increased dose or number of drug-coated balloon (DCB) inflations increases drug delivery and tissue retention – this […]

MDD: Pre-clinical studies of implantable medical devices: Lessons from the front lines

Peter Markham, MS and Rami Tzafriri, PhD. ‘Pre-clinical studies of implantable medical devices: Lessons from the front lines..’ Summary: Surveying three example cases of pre-clinical studies of combination medical devices, the presentation attempts to illustrate 3 key lessons: First follower – Don’t just follow first generation testing paradigm. Speed and differentiation are most important New product […]

TCT 2016: Multiple drug coated balloon exposures increase arterial permeability and drug retention

Rami Tzafriri; Brett Zani; Steve Alston; Elazer Edelman. ‘Multiple drug coated balloon exposures increase arterial permeability and drug retention.’ Poster presented at: Transcatheter Cardiovascular Therapeutics (TCT), Oct 25-Nov 2, 2016, Washington, DC. Summary: It is thought that increased dose or number of drug-coated balloon (DCB) inflations increases drug delivery and tissue retention – this however has […]

SNIS: Preclinical Evaluation of Mechanical Thrombectomy Devices in a Swine Clot Model

L Bailey, AS; M Gilvarry; M Holian; R Tzafriri, PhD, J Keating, DVM, DACVP, E Edelman, MD, PhD, FACC. ‘Preclinical Evaluation of Mechanical Thrombectomy Devices in a Swine Clot Model.’ Summary: Successful recanalization (TICI ≥2b) using mechanical thrombectomy (MT) with stent retriever devices is associated with good outcomes in the treatment of ischemic stroke. Preclinical TICI […]

EuroPCR: Solubility-controlled sirolimus release from drug-filled stents

Tzafriri A, Garcia-polite F, Schulz-jander D, Melder R, Goshgarian J, Tunev S, Stone G, Edelman E. ‘Solubility-controlled sirolimus release from drug-filled stents.’ Summary: Whereas drug diffusion is typically the rate-limiting release mechanism observed in other polymer-coated drug-eluting stents (DES), drug release from prototype DFS is determined by a complex dissolution-precipitation mechanism sensitive to the equilibrium solubility […]

EuroPCR: Plaque modification with an orbital atherectomy system enhances drug distribution in calcified peripheral arteries

Tzafriri A., Nikanorov A., Zani B., Stanley J., Garcia-polite F., Budrewicz J., Knutson J., Kohler R., Markham P., Edelman E. ‘Plaque modification with an orbital atherectomy system enhances drug distribution in calcified peripheral arteries.’ Summary: Calcific atherosclerosis is a major challenge to intraluminal drug delivery treatments in peripheral artery disease. We evaluated the effects of […]