CBSET Director of Research and Innovation, Rami Tzafriri, PhD, presented: “Porcine Model of Catheter Based Treatment of Pulmonary Embolization” as part of the session From Pulmonary Embolism to Pulmonary Hypertension at the ICI for All 2024 meeting in Tel Aviv, Israel. In this invited presentation, Dr. Tzafriri reviewed CBSET’s innovative porcine clot models and their […]
Rami Tzafriri, Lee-Jae Jack Guo, Benny Muraj, Peter Markham, Curtis Genstler, Joseph Czyscon, Christopher Piere, Christopher Knapp, Elazer R. Edelman. Ultrasound-enhanced clot thrombolysis in a porcine model of pulmonary embolism. BACKGROUND: Catheter directed thrombolysis (CDT) delivering Tissue Plasminogen Activator (tPA) and Ultrasound (US) has shown clinical benefit, but the additional in vivo impact of US […]
Rami Tzafriri, Lee-Jae Jack Guo, Benny Muraj, Peter Markham, Curtis Genstler, Joseph Czyscon, Christopher Piere, Christopher Knapp, Elazer R. Edelman. Ultrasound-enhanced clot thrombolysis in a porcine model of pulmonary embolism. Ultrasound-assisted catheter-directed thrombolysis enhances right ventricular recovery after acute PE, but optimization is limited by lack of good animal models. We developed a porcine model […]
Sanchez S, Bailey L, Ducore R, Andersson T, Nogueira R, Cognard C, Ribo M, Villanova H, Rios A, Galve I. “Preclinical evaluation of the ANCD thrombectomy device: safety and efficacy in a swine clot model” Summary: The Advanced Thrombectomy System (ANCD) provides a new funnel component designed to reduce clot fragmentation and facilitate retrieval in patients […]
Michael Naimark. “Swine Clot Model for the Evaluation of Mechanical Thrombectomy Devices” Summary: Restoration of d blood flow (TICI>2b) downstream of a proximal cerebral artery has been established as the definitive treatment for acute ischemic stroke (AIS). In recent years mechanical thrombectomy (MT) using stent retrievers has overtaken thrombolysis as the therapy of choice for AIS. […]
L Bailey, AS; M Gilvarry; M Holian; R Tzafriri, PhD, J Keating, DVM, DACVP, E Edelman, MD, PhD, FACC. ‘Preclinical Evaluation of Mechanical Thrombectomy Devices in a Swine Clot Model.’ Summary: Successful recanalization (TICI ≥2b) using mechanical thrombectomy (MT) with stent retriever devices is associated with good outcomes in the treatment of ischemic stroke. Preclinical TICI […]