Rami Tzafriri. “Quantitative preclinical insights into procedural and anatomical determinants of multi-electrode renal denervation efficacy” Summary: Radiofrequency renal denervation (RDN) is under investigation for treatment of hypertension with variable success. First generation systems used a single, monopolar radiofrequency (RF) electrode to sequentially ablate a series of angularly staggered locations along the endoluminal surface of the renal […]
Tag Archives: 2019
Endovascular Today: Computational Model Suggests a New Paradigm for Accelerated Treatment Optimization With Paclitaxel Devices
CBSET announced that its scientists have published data and analyses that provide critical insights into the interplay between target anatomy and device attributes in determining balloon- and stent-based paclitaxel retention in healthy and diseased arteries. According to CBSET, these findings may transform the understanding of the safety and efficacy of paclitaxel-coated devices used in the […]
Press Release: Computational model of coating and tissue morphology determinants of balloon based drug retention and tissue dosing suggest a new paradigm for accelerated treatment optimization: CBSET data published in Journal of Controlled Release
“This mechanistic model empowers and reassures clinicians about the amount of active paclitaxel that our patients are exposed to, while offering insights and a framework for accelerating the preclinical development of new technologies such as those including sirolimus,” said Sahil A. Parikh, M.D., co-author and Director of Endovascular Services at the Columbia University College of […]
Endovascular Today: Computational Model Suggests a New Paradigm for Accelerated Treatment Optimization With Paclitaxel Devices
August 28, 2019—CBSET announced that its scientists have published data and analyses that provide critical insights into the interplay between target anatomy and device attributes in determining balloon- and stent-based paclitaxel retention in healthy and diseased arteries. According to CBSET, these findings may transform the understanding of the safety and efficacy of paclitaxel-coated devices used […]
Journal of Controlled Release: Taking paclitaxel coated balloons to a higher level: Predicting coating dissolution kinetics, tissue retention and dosing dynamics
Abraham R.Tzafriri, Sahil A.Parikh, Elazer R.Edelman. “Taking paclitaxel coated balloons to a higher level: Predicting coating dissolution kinetics, tissue retention and dosing dynamics.” Summary: Paclitaxel coated balloons (PCBs) are a promising non-implantable alternative to drug-eluting stents, whereby drug is delivered to the arterial wall in solid form as a semi-continuous solid coating or as micro drug […]
Lymphat Res Biol: Development of a Porcine Lymph Drainage Model to Study Particle Migration
Spenciner DB, Barber FA, Zani BG, Melidone R, Muench TR. “Development of a Porcine Lymph Drainage Model to Study Particle Migration.” Summary: Intra-articular wear particulate migration from the knee joint has been studied in various animal models as well as postmortem in patients who received total knee joint replacement. However, there still exists a need […]
Press Release: The procedural and anatomical determinants of second-generation renal denervation therapy are explained by local tissue anatomy, suggesting a new paradigm for treatment optimization: CBSET data published in Hypertension
“The combination of quantitative preclinical experiments and computational models have expanded our understanding of the mechanisms that facilitate circumferential nerve ablation and clinical efficacy. These data help complete the puzzle for device innovators, and aid in the advancement of specific approaches to treat diseases involving sympathetic denervation and modulation,” said Peter M. Markham, President and […]
Translational Research: Splenic artery denervation: target micro-anatomy, feasibility, and early preclinical experience
Mazen Albaghdadi, Fernando Garcia-Polite, Brett Zani, John Keating, Raffaele Melidone, Anna Spognardi, Peter Markham, Abraham Tzafriri. “Splenic artery denervation: target micro-anatomy, feasibility, and early preclinical experience.” Summary: This study sought to evaluate perisplenic artery nerve distribution and the feasibility of splenic artery denervation (SDN). The NEXION radiofrequency catheter was used to perform SDN in healthy and […]
STP: Ototoxicity Related to Cisplatin: Does Gender Matter?
Cyrille Sage, Aurore Marie, Randolph Abutin, Rami Tzafriri. “Ototoxicity Related to Cisplatin: Does Gender Matter?“ Summary: Cisplatin is a first-line treatment of several cancers. Adverse effects include nephrotoxicity, neurotoxicity, and ototoxicity with no preventative treatment for the latter. Cisplatin treatment often results in a bilateral elevation of hearing threshold resulting in irreversible hearing loss. In the […]
Hypertension: Procedural and Anatomical Determinants of Multielectrode Renal Denervation Efficacy
Hypertension editors selected this paper for their 2019 Fall Collection of High Impact Papers. Tzafriri AR, Mahfoud F, Keating JH, Spognardi AM, Markham PM, Wong G, Highsmith D, O’Fallon P, Fuimaono K, Edelman ER. Procedural and Anatomical Determinants of Multielectrode Renal Denervation Efficacy. Summary: Radiofrequency renal denervation is under investigation for treatment of hypertension with […]