Join CBSET at the ICI For All 2024 Meeting, to explore the latest advancements in treatment of the heart, brain, and vascular disease, December 9-10, in Tel Aviv, Israel.
CBSET Director of Research and Innovation, Rami Tzafriri, PhD, will be presenting as part of the scientific program, Innovations in Cardiovascular Interventions:
"The Common Hepatic Artery is a Rich Target for Sympathetic Denervation" in the Session: Device-based Hypertension Treatment - Ready for Prime Time? Monday, December 9, 2:00 PM.
"Influence of DCB Design and Procedural Parameters on Drug Delivery" in the Session: DES, BRS & DCB - New Insights, Monday, December 9, at 3:12 PM.
Learn more about CBSET's work on Peripheral Artery Disease (PAD).
Learn more about CBSET's approach to the study of Thrombectomy & Thrombolysis technologies.Recent scientific publications/presentations related to CBSET's work on Sympathetic Denervation:
Twelve Week Safety and Efficacy of a Novel Extravascular Bi-lateral Renal Denervation Device in a Porcine Model at Nominal Dose. Chang Wook Jeong, Jay Budrewicz, John H. Keating, Misty Williams-Fritze, Peter Markham, Rami Tzafriri. Presented at TCT 2024, October 27-30, 2024, Washington, DC
Morphometric analysis of the human common hepatic artery (CHA) reveals a rich and accessible target for sympathetic liver denervation. Abraham Rami Tzafriri PhD, Fernando Garcia-Polite PhD, John Keating DVM DACVP et al. Scientific Reports, 10.1038/s41598-022-05475-6
Combined renal and common hepatic artery denervation as a novel approach to reduce cardiometabolic risk: technical approach, feasibility and safety in a pre-clinical model. Márcio Galindo Kiuchi, Kavitha Ganesan, John Keating et al. Clin Res Cardiol. 2021 May;110(5):740-753. doi: 10.1007/s00392-021-01814-1.
Pulsed Field Ablation Using a Lattice Electrode for Focal Energy Delivery: Biophysical Characterization, Lesion Durability, and Safety Evaluation. Hagai Yavin, Ayelet Shapira-Daniels, Michael Barkagan, Jakub Sroubek, David Shim, Raffaele Melidone, Elad Anter. Circulation: Arrhythmia and Electrophysiology 2020 Jun;13(6):e008580.
"Procedural and Anatomical Determinants of Multielectrode Renal Denervation Efficacy." Tzafriri AR, Mahfoud F, Keating JH, Spognardi AM, Markham PM, Wong G, Highsmith D, O'Fallon P, Fuimaono K, Edelman ER.
Hypertension. 2019 Sep;74(3):546-554. doi: 10.1161/HYPERTENSIONAHA.119.12918.
"Arterial microanatomy determines the success of energy-based renal denervation in controlling hypertension." Tzafriri AR, Keating JH, Markham PM, Spognardi AM, L Stanley JR, Wong G, Zani BG, Highsmith D, O’Fallon P, Fuimaono K, Mahfoud F, Edelman ER. Science Translational Medicine. 2015 Apr 29;7(285):285ra65. doi: 10.1126/scitranslmed.aaa3236.
"Renal denervation: Not as easy as it looks." Editorial in Science Translational Medicine by Murray Esler Baker IDI Heart and Diabetes Institute, Melbourne, Victoria, Australia.
"Microanatomy impacts on RDN." Editorial in Nature Reviews Nephrology by Jessica K. Edwards.
Recent CBSET scientific papers & presentations related to novel PAD therapies:
Balloon-based drug coating delivery to the artery wall is dictated by coating micro-morphology and angioplasty pressure gradients Abraham R. Tzafriri, Benny Muraj, Fernando Garcia-Polite, Antonio G. Salazar-Martín, Peter Markham, Brett Zani, Anna Spognardi, Mazen Albaghdadi, Steve Alston, Elazer R. Edelman. Biomaterials. 2020 Nov;260:120337.
Taking paclitaxel coated balloons to a higher level: Predicting coating dissolution kinetics, tissue retention and dosing dynamics. Abraham R.Tzafriri, Sahil A.Parikh, Elazer R.Edelman. Journal of Controlled Release. Volume 310, 28 September 2019, Pages 94-102.
Enhanced Plaque Modification of Cadaveric Human Calcified Peripheral Arteries Treated with a Vessel Preparation System. Video interview at CRT19. CBSET’s Director of Research and Innovation, Rami Tzafriri, PhD, discusses CBSET’s human cadaver model assessment of a vessel preparation system and the attributes of this particular technology that suggest it might be conducive to enhancing drug absorption.
Calcified plaque modification alters local drug delivery in the treatment of peripheral atherosclerosis. Abraham R. Tzafriri, Fernando Garcia-Polite, Brett Zani, James Stanley, Benny Muraj, Jennifer Knutson, Robert Kohler, Peter Markham, Alexander Nikanorov, Elazer R. Edelman, Journal of Controlled Release, Volume 264, 28 October 2017, Pages 203-210.
Evaluation of a novel paclitaxel coated intravascular balloon. Abraham R. Tzafriri, PhD. Presented at CX 2017 – The Charing Cross International Symposium, April 25-28, Kensington, London, UK.
Mechanisms Underlying Drug Delivery to Peripheral Arteries. Li J, Tzafriri R, Patel SM, Parikh SA. Interventional Cardiology Clinics. 2017 Apr;6(2):197-216. doi: 10.1016/j.iccl.2016.12.004.
Two Blades-Up Runs Using the JetStream Navitus Atherectomy Device Achieve Optimal Tissue Debulking of Nonocclusive In-Stent Restenosis: Observations From a Porcine Stent/Balloon Injury Model. Shammas NW, Aasen N, Bailey L, Budrewicz J, Farago T, Jarvis G. Journal of Endovascular Therapy. 2015 Aug;22(4):518-24.
Effects of Orbital Atherectomy Treatment on Drug Absorption in Calcified Peripheral Arteries. Elazer R. Edelman, MD. Presented at CRT15 – Cardiovascular Research Technologies (CRT); 2015 Feb 21-24; Washington, DC.
Mechanisms of Tissue Uptake and Retention in Zotarolimus-Coated Balloon Therapy. Vijaya B. Kolachalama, Stephen D. Pacetti, Joseph W. Franses, John J. Stankus, Hugh Q. Zhao, Tarek Shazly, Alexander Nikanorov, Lewis B. Schwartz, Abraham R. Tzafriri, Elazer R. Edelman. Circulation. 2013;127:2047-2055.
Correlative evaluation of variable pressure-scanning electron microscopy to histology methods for vascular tissues. P. Seifert, K. Regan, B.G. Zani, G. Wong, and J. Stanley. Journal of Histotechnology, 2013 March; 36 (1): 25-29.
Recent scientific papers/presentations related to CBSET's work on Mechanical Thrombectomy research:
Preclinical evaluation of the ANCD thrombectomy device: safety and efficacy in a swine clot mode. Sanchez S, Bailey L, Ducore R, Andersson T, Nogueira R, Cognard C, Ribo M, Villanova H, Rios A, Galve I. Journal of Neuerointerventional Surgery, 2020 Oct;12(10):1008-1013. doi: 10.1136/neurintsurg-2019-015548.
Swine Clot Model for the Evaluation of Mechanical Thrombectomy Devices. M Naimark. Presented at: Biointerface 2019, Park City, Utah, September 4-6, 2019.
Preclinical Evaluation of Mechanical Thrombectomy Devices in a Swine Clot Model. L Bailey, AS; M Gilvarry; M Holian; R Tzafriri, PhD, J Keating, DVM, DACVP, E Edelman, MD, PhD, FACC. Poster presented at: Society of Neurointerventional Surgery (SNIS), Boston, USA, July 25-29, 2016.