"Modeling of drug-coated balloon inflation correlates drug transfer with vessel geometry and balloon design." Efstathios Stratakos, Rami Tzafriri, Benny Muraj, Jay Budrewicz, Anna Maria Spognardi, Linnea Tscheuschner, Fragiska Sigala, Lorenza Petrini, Giancarlo Pennati.
Presentation by Efstathios Stratakos at 29th Contrass of the European Society of Biomechanics, on July 2, 2024, at 12:10 pm, Edinburgh, Scotland.
Drug-coated balloons (DCB) are designed to deliver drug-loaded coating at the arterial inflation site. While DCBs have shown efficacy in treating femoropopliteal peripheral artery disease, clinical and preclinical outcomes vary with lesion complexity and DCB technology. To understand their variable performance, we developed and validated a 3D computational model of DCB inflation and correlated experimental coating distribution maps (CDM) following acute in vivo treatments of pig superficial femoral artery (SFA) with computationally predicted endoluminal maps of contact pressure (CP) in digital replicas.
This project received funding from the European Union's Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant agreement No 95470.