CELEBRATING 12 YEARS AT CBSET... Dr. John Keating is a Diplomate of the American College of Veterinary Pathology, with years of experience in contract research and preclinical safety evaluations, including gross and microscopic pathology, pathophysiology, specialized staining, and imaging procedures across a variety of device classes and large- and small-animal species, and is well-versed in development, execution, presentation and regulatory navigation of preclinical studies.


1: He is a key opinion leader in the pathology field.

The research of John and his colleagues was presented as a preclinical paradigm for safety assessment of energy-based devices at a Society of Toxicology annual meeting. “We developed a preclinical model for predictably modulating the efficacy of thermal ablation devices, while simultaneously minimizing adverse effects on target and surrounding tissues,” he explains. “Catheter-based renal denervation therapies deliver RF energy from within the renal artery, to denervate the surrounding nerves to modulate the sympathetic nervous system as a therapy for drug-resistant hypertension. The challenge was how to balance the local benefits of denervation with potential adverse effects to the artery wall and surrounding organs? Our studies focused on defining the microanatomy of the renal artery as well as on quantifying the impact of intravascular delivery of RF energy on the local anatomy—to wit, inducing efficacy by denervation of the local nerves and demonstrating safety to the artery wall and surrounding tissues.”

2: He has broad pathology expertise.

Since joining CBSET, John has predominantly focused on evaluating tissue responses related to novel biomedical devices and techniques. “The goal of our pathology team is to work together with sponsors, scientists, and internal experts to produce high-quality results that accurately and efficiently represent safety and performance of drugs and devices,” he says. Toward that end, John emphasizes that CBSET provides a GLP-compliant facility that is staffed by an experienced team of ACVP-board-certified veterinary pathologists as well as experienced scientists, necropsy technicians, and HT-certified histotechnicians. John is a co-author of numerous published scientific papers in peer- reviewed academic journals such as Veterinary Pathology.

3: He is a diplomate of ACVP.

The American College of Veterinary Pathologists (ACVP) is the oldest veterinary specialty organization recognized by the American Veterinary Medical Association (AVMA). ACVP is a nonprofit organization that sets the standard for veterinary pathology. The mission of the College is to promote excellence in veterinary pathology through its members as they protect and improve animal, human and environmental health to benefit society. All ACVP Diplomates have completed a degree in veterinary medicine, at least 3 years of post-veterinary school training, and have passed the certifying examination in veterinary pathology. They have diverse roles in academia, diagnostic labs, industry, or state or federal government agencies. “ACVP's rigorous certifying examination ensures scientific prestige,” says John.

Watch: CBSET's John Keating presents In Vivo Models to Assess Ototoxicity

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