Category Archives: Press Releases

Press Release: CBSET-CILcare to report experimental methodologies for performing translational auditory research in pigs and sheep at the ‘ARO Midwinter Meeting’

“Auditory research studies are typically performed using rodent models. Yet, some studies may require a larger species with middle and inner ear anatomy more similar to humans,” said Misty Williams-Fritze, DVM, MS, DACLAM, PhD, and Cyrille Sage, PhD, co-lead researchers LEXINGTON, MA, Jan. 23, 2020  — — CBSET Inc., a not-for-profit translational research institute, announced […]

Press Release: CBSET’s CEO Peter Markham honored as ‘2019 Biomedical Research Business Leader’ by Massachusetts Society for Medical Research (MSMR)

LEXINGTON, MA, Oct. 24, 2019 — CBSET Inc., a not-for-profit preclinical research institute dedicated to biomedical research, education, and advancement of medical technologies, announced today that its co-founder, president and chief executive officer, Peter Markham, has been named ‘2019 Biomedical Research Business Leader’ by the Massachusetts Society for Medical Research (MSMR). He will be honored at a […]

Press Release: Computational model of coating and tissue morphology determinants of balloon based drug retention and tissue dosing suggest a new paradigm for accelerated treatment optimization: CBSET data published in Journal of Controlled Release

“This mechanistic model empowers and reassures clinicians about the amount of active paclitaxel that our patients are exposed to, while offering insights and a framework for accelerating the preclinical development of new technologies such as those including sirolimus,” said Sahil A. Parikh, M.D., co-author and Director of Endovascular Services at the Columbia University College of […]

Press Release: The procedural and anatomical determinants of second-generation renal denervation therapy are explained by local tissue anatomy, suggesting a new paradigm for treatment optimization: CBSET data published in Hypertension

“The combination of quantitative preclinical experiments and computational models have expanded our understanding of the mechanisms that facilitate circumferential nerve ablation and clinical efficacy. These data help complete the puzzle for device innovators, and aid in the advancement of specific approaches to treat diseases involving sympathetic denervation and modulation,” said Peter M. Markham, President and […]

Press Release: CBSET partner CILcare leads Phase 2 of $2.1 million total DETECT project to develop a preclinical model for tinnitus drug therapy development

LEXINGTON, Mass., and MONTPELLIER, France, Nov. 12, 2018 — CBSET partner CILcare, a world-leading CRO (clinical research organization) specialized in the research and development of drugs and medical devices in the field of hearing, has initiated the second phase of its ongoing tinnitus research project, DETECT, a public/private project being conducted in collaboration with the […]

Press Release: Preclinical safety studies demonstrate that drug presence can accentuate pathological responses at stent fracture sites

“These findings could potentially have a seminal effect on development of innovative DES coating designs to treat coronary artery disease,” said Rami Tzafriri, Ph.D., Director of Research and Innovation, CBSET. “Animal models of real-world scenarios such as stent fracture offer an exciting opportunity to differentiate the relative effectiveness of novel drug eluting stent designs that […]

Press Release: Study Validates New Approach for Optimizing Endovascular Drug Delivery Using Stents with a Deployable Coating That Enhances Sirolimus Distribution Compared to Traditional DES

“Defining drug and target protein distributions after stent-based drug release: Durable versus deployable coatings” published online in Journal of Controlled Release “This preclinical demonstration of the enhanced and more uniform drug and biomarker distribution by stents with deployable coatings could lead to more rapid and improved healing after stent implantation,” said David Kandzari, M.D., Director […]

Press Release: Preclinical safety studies must include equally balanced male/female animal models to shed light on sex-dependent vascular responses in humans

“Sex Differences in the Outcomes of Stent Implantation in Mini-Swine Model” published in PLOS ONE “Retrospective analyses of pooled animal data can provide important insights into sex-dependent anatomic and pathophysiologic differences,” said Rami Tzafriri, PhD, Director of Research and Innovation, CBSET. LEXINGTON, Mass., Feb. 12, 2018 – CBSET, a non-for-profit preclinical research institute dedicated to […]

Press Release: CILcare’s age-related hearing loss model enriched with NAC as positive control

Preclinical data to be presented at annual mid-winter meeting of the Association of Research in Otolaryngology (ARO) LEXINGTON, Mass., Feb. 8, 2018 – CILcare Inc.,the world’s leading CRO specializing in hearing therapies, will present preclinical data at the upcoming “ARO 14th Annual Mid-Winter Meeting” in San Diego validating the effect of NAC natural active ingredient in […]