Tzafriri AR, Rotllant Daurella L,Keating JH, Garcia Polite F, Li X, Bailey L, Markham PM, Dutta D, Stoll HP, Edelman ER. “Visualizing the tissue distribution and retention of Sirolimus and analog delivered from polymer free drug coated stents” Summary: Biolimus A9 is a highly lipophilic Sirolimus analog (13-fold the lipophilicity of the parent drug) specifically […]

Rami Tzafriri, PhD and Michael Naimark, MS. “Lessons Learned from the Front Lines.” Summary: The Directors of Research and Innovation and Business Development presented advice and lessons learned from CBSET Inc.’s experiences on how to differentiate a new technology and navigate through a successful path to the market, and how to find the correct testing paradigm […]

Rami Tzafriri, PhD. “Stent based tissue drug and binding target protein distributions: durable versus deployable coatings.” Summary: We developed immunofluorescence (IF) methods to track drug and target protein distribution in stented arteries, to aid the development and assessment of novel stent designs. Xience Pro (74 μg Everolimus/3.0×15 mm, durable coating) and MiStent (135 μg Sirolimus/3.0×15 mm, […]

Misty Williams-Fritze DVM, MS, DACLAM. “Academy of Surgical Research: Benecalorie Nutritional Supplement as a Component of Liquid Diet in Swine.” Summary: Swine are commonly utilized in research of the gastrointestinal tract (GIT), where unobstructed access to the upper or lower GIT is necessary for biomedical device evaluation. We regularly use a liquid diet developed by our facility, […]

Rami Tzafriri, PhD. ‘Particulate embolization from catheter coatings.’ Summary: Medical catheters permit minimally invasive external access for monitoring, imaging, sampling, local delivery of therapeutic agents, and placement of devices like endovascular stents, aneurysm coils and transcatheter valves. Catheter coatings are employed extensively as enhancers of device lubriciousness/ steerability and as platforms for local drug delivery. […]

Rami Tzafriri, PhD. “Plaxitel-Coated PTA Balloon Catheter: microcrystalline coating for improved delivery and retention.” Summary: Drug coated balloons are a promising therapy for peripheral arterial disease, but differences in efficacy between devices and non-responders cannot be understood using current methods. To address this void, we developed methods for visualizing and quantifying coating distribution on arterial surfaces […]

Abraham Rami Tzafriri, Lynn Bailey, John Keating, Peter Markham, Debashis Dutta, Margaret Kayo, Elazer R. Edelman. ‘Sirolimus analog lipophilicity dictates release kinetics and tissue retention after implantation of polymer free drug coated stents.’ Poster presented at: EuroPCR, May 16-19, 2017, Paris, France.

Peripheral Innovation: Evaluation of a novel paclitaxel-coated intravascular balloon. Rami Tzafriri, PhD Summary: The presentation illustrated an innovative preclinical paradigm for evaluating and optimizing novel drug-coated balloon technologies by combining bioanalysis with imaging of the coating distribution. Presented at: CX 2017 – The Charing Cross International Symposium, April 25-28, Kensington, London, UK.

*BTI* From Benchtop to Clinical Trial: Examples of technology development. Rami Tzafriri, PhD Summary: Drawing on examples from renal denervation and other thought-leader debates at the conference, the presentation focused on several issues, including whether benchtop-to-clinical is the only path for new medical technologies, the roles and advantages of preclinical vs clinical trials in technology development, and […]