Rami Tzafriri, Felix Mahfoud, Sahil A. Parikh, Elazer Edelman. “Quantification of Procedural and Anatomical Determinants of Multi-electrode Renal Denervation” Background: The failure of the prospective, randomized, sham-controlled SYMPLICITY HTN-3 trial to show significant difference in reduction of systolic BP (SBP) in patients with resistant hypertension 6 months after RDN compared to controls was attributed in […]
Category Archives: Presentations
AACR Special Conference on Pancreatic Cancer: Targeted and sustained drug delivery therapy for localized pancreatic cancer: In vivo validation in porcine models
Margaret Lashof-Sullivan, Amanda L. McSweeney, David T. Ting, Michael P. Kim, Ching-Wei D. Tzeng, Laura Indolfi. “Targeted and sustained drug delivery therapy for localized pancreatic cancer: In vivo validation in porcine models“ Poster presentation at AACR Special Conference on Pancreatic Cancer: Advances in Science and Clinical Care; September 6-9, 2019; Boston, MA. Proceedings of the […]
Biointerface 2019: Swine Clot Model for the Evaluation of Mechanical Thrombectomy Devices
Michael Naimark. “Swine Clot Model for the Evaluation of Mechanical Thrombectomy Devices” Summary: Restoration of d blood flow (TICI>2b) downstream of a proximal cerebral artery has been established as the definitive treatment for acute ischemic stroke (AIS). In recent years mechanical thrombectomy (MT) using stent retrievers has overtaken thrombolysis as the therapy of choice for AIS. […]
Biointerface 2019: Quantitative preclinical insights into procedural and anatomical determinants of multi-electrode renal denervation efficacy
Rami Tzafriri. “Quantitative preclinical insights into procedural and anatomical determinants of multi-electrode renal denervation efficacy” Summary: Radiofrequency renal denervation (RDN) is under investigation for treatment of hypertension with variable success. First generation systems used a single, monopolar radiofrequency (RF) electrode to sequentially ablate a series of angularly staggered locations along the endoluminal surface of the renal […]
STP: Ototoxicity Related to Cisplatin: Does Gender Matter?
Cyrille Sage, Aurore Marie, Randolph Abutin, Rami Tzafriri. “Ototoxicity Related to Cisplatin: Does Gender Matter?“ Summary: Cisplatin is a first-line treatment of several cancers. Adverse effects include nephrotoxicity, neurotoxicity, and ototoxicity with no preventative treatment for the latter. Cisplatin treatment often results in a bilateral elevation of hearing threshold resulting in irreversible hearing loss. In the […]
Partnering for FDA Review: Approaches for Preclinical Outsourcing and CRO Evaluation
Michael Naimark. “Partnering for FDA Review: Approaches for Preclinical Outsourcing and CRO Evaluation.“ Summary: Whether you are a large established pharma/device group, a small biotech company, a startup, or an academic spinoff, getting your medical technology into the clinic will likely require partnering with experienced contract research groups with regulatory experience and the infrastructure to […]
St. Jude’s: Partnering for FDA Review: Approaches for Preclinical Outsourcing and CRO Evaluation
Michael Naimark. “Partnering for FDA Review: Approaches for Preclinical Outsourcing and CRO Evaluation.“ Summary: Whether you are a large established pharma/device group, a small biotech company, a startup, or an academic spinoff, getting your medical technology into the clinic will likely require partnering with experienced contract research groups with regulatory experience and the infrastructure to support […]
EuroPCR: Evaluation of splenic artery denervation: rationale, feasibility, and early pre-clinical experience
Rami Tzafriri, PhD. “Evaluation of splenic artery denervation: rationale, feasibility, and early pre-clinical experience.” Summary: The spleen plays an important role in the immune response to inflammatory conditions including cancer, myocardial infarction and atherosclerosis. Device-based neuromodulation of the spleen’s neural pathways is an emerging therapeutic approach to regulating the immune response in various inflammatory diseases. We evaluated […]
EuroPCR: Vessel preparation system for enhanced plaque modification – Results in calcified human cadaver peripheral arteries
Tzafriri AR. “Vessel preparation system for enhanced plaque modification – Results in calcified human cadaver peripheral arteries“ Summary: Dr. Tzafriri discussed CBSET’s human cadaver model assessment of a vessel preparation system and the attributes of this particular technology that suggest it might be conducive to enhancing drug absorption. Presented at EuroPCR, 2019 May 21-24, 2019, […]
ATVB|PVD Scientific Sessions: In vivo Imaging Assessment of Arterial Permeability Using Indocyanine Green: Implications for Optimizing Drug-Coated Balloon Treatment of Atherosclerosis
Mazen Albaghdadi, Zhonglie Piao, Adam Mauskapf, Mohammed Chowdhury, Rami Tzafriri, Elazer Edelman, Guillermo Tearney, Farouc Jaffer. “In vivo Imaging Assessment of Arterial Permeability Using Indocyanine Green: Implications for Optimizing Drug-Coated Balloon Treatment of Atherosclerosis.” Summary: The efficacy of paclitaxel (PTX) drug-coated balloons (DCBs) in reducing restenosis is limited by Inadequate arterial permeability (AP), yet in vivo […]