Rami Tzafriri, PhD. “Evaluation of splenic artery denervation: rationale, feasibility, and early pre-clinical experience.” Summary: The spleen plays an important role in the immune response to inflammatory conditions including cancer, myocardial infarction and atherosclerosis. Device-based neuromodulation of the spleen’s neural pathways is an emerging therapeutic approach to regulating the immune response in various inflammatory diseases. We evaluated […]
Category Archives: Presentations
EuroPCR: Vessel preparation system for enhanced plaque modification – Results in calcified human cadaver peripheral arteries
Tzafriri AR. “Vessel preparation system for enhanced plaque modification – Results in calcified human cadaver peripheral arteries“ Summary: Dr. Tzafriri discussed CBSET’s human cadaver model assessment of a vessel preparation system and the attributes of this particular technology that suggest it might be conducive to enhancing drug absorption. Presented at EuroPCR, 2019 May 21-24, 2019, […]
ATVB|PVD Scientific Sessions: In vivo Imaging Assessment of Arterial Permeability Using Indocyanine Green: Implications for Optimizing Drug-Coated Balloon Treatment of Atherosclerosis
Mazen Albaghdadi, Zhonglie Piao, Adam Mauskapf, Mohammed Chowdhury, Rami Tzafriri, Elazer Edelman, Guillermo Tearney, Farouc Jaffer. “In vivo Imaging Assessment of Arterial Permeability Using Indocyanine Green: Implications for Optimizing Drug-Coated Balloon Treatment of Atherosclerosis.” Summary: The efficacy of paclitaxel (PTX) drug-coated balloons (DCBs) in reducing restenosis is limited by Inadequate arterial permeability (AP), yet in vivo […]
CRT19 Best Innovation Competition: Enhanced Plaque Modification of Cadaveric Human Calcified Peripheral Arteries Treated with a Vessel Preparation System
Watch: Interview of CBSET’s Director of Research and Innovation, Rami Tzafriri, PhD, by Michael Mooney, MD, of Minneapolis Heart Institute, Abbott Northwestern hospital, at CRT19. Dr. Tzafriri discusses CBSET’s human cadaver model assessment of a vessel preparation system and the attributes of this particular technology that suggest it might be conducive to enhancing drug absorption.
ICI 2018: Enhanced Plaque Modification of Cadaveric Human Calcified Peripheral Arteries Treated with a Dynamic Scoring Catheter
Tzafriri AR. “Enhanced Plaque Modification of Cadaveric Human Calcified Peripheral Arteries Treated with a Dynamic Scoring Catheter“ Summary: Calcific atherosclerosis is a major challenge to intraluminal drug delivery treatments in peripheral artery disease. We evaluated the effects of dynamic scoring on the surface morphology of calcified peripheral arteries. Diagnostic imaging of 2 fresh human cadaveric […]
Biointerface: Immunofluorescence and Computational Methods for Tracking Tissue Distribution of Drugs in Support of Stent Coating Innovations
Tzafriri AR. “Immunofluorescence and Computational Methods for Tracking Tissue Distribution of Drugs in Support of Stent Coating Innovations” Summary: Drug eluting stents (DES) have revolutionized the treatment of atherosclerosis in coronary vasculature. The key has been to identify biological agents that can counter hyperplastic tissue responses to stent expansion/implantation and to develop effective and safe […]
TCT 2018: Tracking tissue distribution and retention of Sirolimus and analog delivered from polymer free drug coated stents
Abraham Rami Tzafriri, Lucas Rotllant Daurella, John Keating, Fernando Garcia Polite, Xiaojian Li, Lynn Bailey, Peter Markham, Debashis Dutta, Hans-Peter Stoll, Elazer R. Edelman. “Tracking tissue distribution and retention of Sirolimus and analog delivered from polymer free drug coated stents” Summary: Biolimus A9 is a highly lipophilic Sirolimus analog (13-fold the lipophilicity of the parent drug) […]
TCT 2018: Superior and proximal nerves in porcine renal arteries are least accessible to radiofrequency ablation due to shielding by peri-arterial blood vessels and lymph nodes
Abraham R. Tzafriri, PhD, Fernando Garcia-Polite, PhD, John H. Keating DVM, DACVP, Anna-Maria Spognardi, BS, Peter Markham, MS, Elazer Edelman, MD, PhD. “Superior and proximal nerves in porcine renal arteries are least accessible to radiofrequency ablation due to shielding by peri-arterial blood vessels and lymph nodes.” Summary: Periarterial lymph nodes and blood vessels can shield nerves […]
TCT 2018: Splenic Artery Denervation: Rationale, Feasibility, and Early Pre-Clinical Experience in a Porcine Model of Inflammatory Arthritis
Mazen Albaghdadi, MD MS, Fernando Garcia-Polite, PhD, Brett Zani, PhD, John Keating DVM, DACVP, Raffaele Melidone, DVM, DACVP, Anna Spognardi, BS, Peter Markham, MS, Abraham Tzafriri, PhD. “Splenic Artery Denervation: Rationale, Feasibility, and Early Pre-Clinical Experience in a Porcine Model of Inflammatory Arthritis.” Summary: The spleen plays an important role in the immune response to inflammatory conditions […]
St. Jude’s: Serving the Gap: Combining GLP Preclinical Standards with Academic Rigor for FDA Review
Michael Naimark. “Serving the Gap: Combining GLP Preclinical Standards with Academic Rigor for FDA Review.“ Summary: Michael discussed the fundamental principles of preclinical program development with an eye towards clinical testing and market approval through the FDA and its branches. He emphasized new regulatory strategies for novel therapeutic approaches in regenerative medicine including the RMAT designation, […]