Mazen Albaghdadi, Zhonglie Piao, Adam Mauskapf, Mohammed Chowdhury, Rami Tzafriri, Elazer Edelman, Guillermo Tearney, Farouc Jaffer. “In vivo Imaging Assessment of Arterial Permeability Using Indocyanine Green: Implications for Optimizing Drug-Coated Balloon Treatment of Atherosclerosis.” Summary: The efficacy of paclitaxel (PTX) drug-coated balloons (DCBs) in reducing restenosis is limited by Inadequate arterial permeability (AP), yet in vivo […]
Watch: Interview of CBSET’s Director of Research and Innovation, Rami Tzafriri, PhD, by Michael Mooney, MD, of Minneapolis Heart Institute, Abbott Northwestern hospital, at CRT19. Dr. Tzafriri discusses CBSET’s human cadaver model assessment of a vessel preparation system and the attributes of this particular technology that suggest it might be conducive to enhancing drug absorption.
Tzafriri AR. “Enhanced Plaque Modification of Cadaveric Human Calcified Peripheral Arteries Treated with a Dynamic Scoring Catheter“ Summary: Calcific atherosclerosis is a major challenge to intraluminal drug delivery treatments in peripheral artery disease. We evaluated the effects of dynamic scoring on the surface morphology of calcified peripheral arteries. Diagnostic imaging of 2 fresh human cadaveric […]
Tzafriri AR. “Immunofluorescence and Computational Methods for Tracking Tissue Distribution of Drugs in Support of Stent Coating Innovations” Summary: Drug eluting stents (DES) have revolutionized the treatment of atherosclerosis in coronary vasculature. The key has been to identify biological agents that can counter hyperplastic tissue responses to stent expansion/implantation and to develop effective and safe […]
Abraham Rami Tzafriri, Lucas Rotllant Daurella, John Keating, Fernando Garcia Polite, Xiaojian Li, Lynn Bailey, Peter Markham, Debashis Dutta, Hans-Peter Stoll, Elazer R. Edelman. “Tracking tissue distribution and retention of Sirolimus and analog delivered from polymer free drug coated stents” Summary: Biolimus A9 is a highly lipophilic Sirolimus analog (13-fold the lipophilicity of the parent drug) […]
Abraham R. Tzafriri, PhD, Fernando Garcia-Polite, PhD, John H. Keating DVM, DACVP, Anna-Maria Spognardi, BS, Peter Markham, MS, Elazer Edelman, MD, PhD. “Superior and proximal nerves in porcine renal arteries are least accessible to radiofrequency ablation due to shielding by peri-arterial blood vessels and lymph nodes.” Summary: Periarterial lymph nodes and blood vessels can shield nerves […]
Mazen Albaghdadi, MD MS, Fernando Garcia-Polite, PhD, Brett Zani, PhD, John Keating DVM, DACVP, Raffaele Melidone, DVM, DACVP, Anna Spognardi, BS, Peter Markham, MS, Abraham Tzafriri, PhD. “Splenic Artery Denervation: Rationale, Feasibility, and Early Pre-Clinical Experience in a Porcine Model of Inflammatory Arthritis.” Summary: The spleen plays an important role in the immune response to inflammatory conditions […]
Michael Naimark. “Serving the Gap: Combining GLP Preclinical Standards with Academic Rigor for FDA Review.“ Summary: Michael discussed the fundamental principles of preclinical program development with an eye towards clinical testing and market approval through the FDA and its branches. He emphasized new regulatory strategies for novel therapeutic approaches in regenerative medicine including the RMAT designation, […]
Kumaran Kolandaivelu, Josep Maria Balaguer, Maria Tomas Gracia, Jose Manuel Sanes, Enric Estruch, Laura Perkins, Syed Hossainy, Rami Tzafriri, Peter Markham, Elazer Edelman. “Local, regional, and systemic factors in BRS thrombosis in small vessels: understanding the sub-2.5mm barrier.“ Summary: Device thrombosis dominates bioresorbable vascular scaffolds (BVS) safety concerns, particularly in sub-2.5mm vessels. To better understand […]
Abraham R. Tzafriri; Arben Muraj; Fernando Garcia-Polite; Peter Markham; Brett Zani; Anna-Maria Spognardi; Steve Alston; Elazer R. Edelman. “Visualizing and quantifying differential distribution of balloon-delivered coating to porcine arteries.“ Summary: Drug coated balloons are a promising therapy for peripheral artery disease, but efficacy varies between devices and with lesion complexity. The accepted hypothesis that coating […]