TCT 2019: Identifying Conditions for Very Late Tissue Retention of Paclitaxel: Insights from Mechanistic Computational Modeling

Rami Tzafriri, Sahil A. Parikh, Juan Granada, Elazer R. Edelman. “Identifying Conditions for Very Late Tissue Retention of Paclitaxel: Insights from Mechanistic Computational Modeling.” Background: A recent meta-analysis of randomized controlled trials investigating paclitaxel-coated balloons and stents in the femoral and/or popliteal arteries reported an increased risk of death 2-5 years after treatment. Yet, no […]

TCT 2019: Quantification of Procedural and Anatomical Determinants of Multi-electrode Renal Denervation

Rami Tzafriri, Felix Mahfoud, Sahil A. Parikh, Elazer Edelman. “Quantification of Procedural and Anatomical Determinants of Multi-electrode Renal Denervation” Background: The failure of the prospective, randomized, sham-controlled SYMPLICITY HTN-3 trial to show significant difference in reduction of systolic BP (SBP) in patients with resistant hypertension 6 months after RDN compared to controls was attributed in […]

AACR Special Conference on Pancreatic Cancer: Targeted and sustained drug delivery therapy for localized pancreatic cancer: In vivo validation in porcine models

Margaret Lashof-Sullivan, Amanda L. McSweeney, David T. Ting, Michael P. Kim, Ching-Wei D. Tzeng, Laura Indolfi. “Targeted and sustained drug delivery therapy for localized pancreatic cancer: In vivo validation in porcine models“ Poster presentation at AACR Special Conference on Pancreatic Cancer: Advances in Science and Clinical Care; September 6-9, 2019; Boston, MA. Proceedings of the […]

Biointerface 2019: Swine Clot Model for the Evaluation of Mechanical Thrombectomy Devices

Michael Naimark. “Swine Clot Model for the Evaluation of Mechanical Thrombectomy Devices” Summary: Restoration of d blood flow (TICI>2b) downstream of a proximal cerebral artery has been established as the definitive treatment for acute ischemic stroke (AIS). In recent years mechanical thrombectomy (MT) using stent retrievers has overtaken thrombolysis as the therapy of choice for AIS. […]

Biointerface 2019: Quantitative preclinical insights into procedural and anatomical determinants of multi-electrode renal denervation efficacy

Rami Tzafriri. “Quantitative preclinical insights into procedural and anatomical determinants of multi-electrode renal denervation efficacy” Summary: Radiofrequency renal denervation (RDN) is under investigation for treatment of hypertension with variable success. First generation systems used a single, monopolar radiofrequency (RF) electrode to sequentially ablate a series of angularly staggered locations along the endoluminal surface of the renal […]

STP: Ototoxicity Related to Cisplatin: Does Gender Matter?

Cyrille Sage, Aurore Marie, Randolph Abutin, Rami Tzafriri. “Ototoxicity Related to Cisplatin: Does Gender Matter?“ Summary: Cisplatin is a first-line treatment of several cancers. Adverse effects include nephrotoxicity, neurotoxicity, and ototoxicity with no preventative treatment for the latter. Cisplatin treatment often results in a bilateral elevation of hearing threshold resulting in irreversible hearing loss. In the […]

Partnering for FDA Review: Approaches for Preclinical Outsourcing and CRO Evaluation

Michael Naimark. “Partnering for FDA Review: Approaches for Preclinical Outsourcing and CRO Evaluation.“ Summary: Whether you are a large established pharma/device group, a small biotech company, a startup, or an academic spinoff, getting your medical technology into the clinic will likely require partnering with experienced contract research groups with regulatory experience and the infrastructure to […]

St. Jude’s: Partnering for FDA Review: Approaches for Preclinical Outsourcing and CRO Evaluation

EuroPCR: Evaluation of splenic artery denervation: rationale, feasibility, and early pre-clinical experience

Rami Tzafriri, PhD. “Evaluation of splenic artery denervation: rationale, feasibility, and early pre-clinical experience.” Summary: The spleen plays an important role in the immune response to inflammatory conditions including cancer, myocardial infarction and atherosclerosis. Device-based neuromodulation of the spleen’s neural pathways is an emerging therapeutic approach to regulating the immune response in various inflammatory diseases. We evaluated […]

EuroPCR: Vessel preparation system for enhanced plaque modification – Results in calcified human cadaver peripheral arteries

Tzafriri AR. “Vessel preparation system for enhanced plaque modification – Results in calcified human cadaver peripheral arteries“ Summary: Dr. Tzafriri discussed CBSET’s human cadaver model assessment of a vessel preparation system and the attributes of this particular technology that suggest it might be conducive to enhancing drug absorption. Presented at EuroPCR, 2019 May 21-24, 2019, […]