TCT 2018: Tracking tissue distribution and retention of Sirolimus and analog delivered from polymer free drug coated stents

Abraham Rami Tzafriri, Lucas Rotllant Daurella, John Keating, Fernando Garcia Polite, Xiaojian Li, Lynn Bailey, Peter Markham, Debashis Dutta, Hans-Peter Stoll, Elazer R. Edelman. “Tracking tissue distribution and retention of Sirolimus and analog delivered from polymer free drug coated stents”

Summary: Biolimus A9 is a highly lipophilic Sirolimus analog (13-fold the lipophilicity of the parent drug) specifically designed for local-drug delivery. We developed immunofluorescence (IF) methods to contrast the arterial distribution of Sirolimus and Biolimus A9 after implantation of polymer-free drug-coated stents (PF DCS) in the pig coronary artery model.

Presented at the Transcatheter Cardiovascular Therapeutics (TCT) Sept 21-25, 2018, San Diego, CA.

http://www.onlinejacc.org/content/72/13_Supplement/B204.1