Abraham Rami Tzafriri PhD, Fernando Garcia-Polite PhD, John Keating DVM DACVP, Raffaele Melidone DVM DACVP, Jennifer Knutson BS, Peter Markham MS, Elazer R. Edelman MD PhD, Felix Mahfoud MD. “Morphometric analysis of the human common hepatic artery (CHA) reveals a rich and accessible target for sympathetic liver denervation.” FULL ARTICLE Summary: Treatment of type 2 […]
Tag Archives: JK
Clinical Research in Cardiology: Combined renal and common hepatic artery denervation as a novel approach to reduce cardiometabolic risk: technical approach, feasibility and safety in a pre-clinical model
Márcio Galindo Kiuchi, Kavitha Ganesan, John Keating, Revathy Carnagarin, Vance B Matthews, Lakshini Y Herat, Gerard Goh, Leon Adams, Markus P Schlaich. “Combined renal and common hepatic artery denervation as a novel approach to reduce cardiometabolic risk: technical approach, feasibility and safety in a pre-clinical model.” Abstract: Background: Cardiovascular and metabolic regulation is governed by […]
Translational Research: Splenic artery denervation: target micro-anatomy, feasibility, and early preclinical experience
Mazen Albaghdadi, Fernando Garcia-Polite, Brett Zani, John Keating, Raffaele Melidone, Anna Spognardi, Peter Markham, Abraham Tzafriri. “Splenic artery denervation: target micro-anatomy, feasibility, and early preclinical experience.” Summary: This study sought to evaluate perisplenic artery nerve distribution and the feasibility of splenic artery denervation (SDN). The NEXION radiofrequency catheter was used to perform SDN in healthy and […]
Hypertension: Procedural and Anatomical Determinants of Multielectrode Renal Denervation Efficacy
Hypertension editors selected this paper for their 2019 Fall Collection of High Impact Papers. Tzafriri AR, Mahfoud F, Keating JH, Spognardi AM, Markham PM, Wong G, Highsmith D, O’Fallon P, Fuimaono K, Edelman ER. Procedural and Anatomical Determinants of Multielectrode Renal Denervation Efficacy. Summary: Radiofrequency renal denervation is under investigation for treatment of hypertension with […]
Toxicologic Pathology: Preclinical Evaluation of Mesh Implants: The Pathologist’s Perspective
Keating JH, Melidone R, Garcia-Polite F. “Preclinical Evaluation of Mesh Implants: The Pathologist’s Perspective.” Summary: Surgical and laparoscopic implantation of mesh devices is on the rise for a variety of applications. The complexity and range of evolving mesh designs calls for consistent and detailed pathologic evaluation in determining host responses and assessing overall safety. This review […]
Toxicologic Pathology: An Overview on the Considerations for the Planning of Nonclinical Necropsies for Medical Device Studies
Stanley JRL, Keating JH, San Souci KJ. “An Overview on the Considerations for the Planning of Nonclinical Necropsies for Medical Device Studies” Summary: The terminal collection and histological processing of medical devices is an expensive, labor-, and material-intensive endeavor, which requires adequate experience, innovation, and preparation for success. It is also an exciting endeavor that continually […]
Catheterization and Cardiovascular Interventions: Fracture in drug-eluting stents increases focal intimal hyperplasia in the atherosclerosed rabbit iliac artery
Conway C, Desany GJ, Bailey LR, Keating JH, Baker BL, Edelman ER. Fracture in drug-eluting stents increases focal intimal hyperplasia in the atherosclerosed rabbit iliac artery. Summary: Controlled release of therapeutic agents, such as sirolimus and its analogs, or paclitaxel, has reduced tissue-based drug-eluting stent failure modes compared to bare metal stents. In the stent, restenosis […]
International Journal of Toxicology: Percutaneous Hepatic Perfusion With Filtered Melphalan for Localized Treatment of Metastatic Hepatic Disease: A Risk Assessment
Pauline E McEwan, Lynn Bailey, David Trost, Christopher Scull, John H Keating, Misty Williams, Robert J Guttendorf. Percutaneous Hepatic Perfusion With Filtered Melphalan for Localized Treatment of Metastatic Hepatic Disease: A Risk Assessment. Summary: Regional therapies for metastatic liver disease have garnered interest in recent years due to technological advances in drug delivery. A percutaneous […]
Respirology: Pharmacokinetics and safety of paclitaxel delivery into porcine airway walls by a new endobronchial drug delivery catheter
Tsukada H, Entcheva-Dimitrov P, Ernst A, Rafeq S, Keating JH, Seward KP, Yarmus L. Pharmacokinetics and safety of paclitaxel delivery into porcine airway walls by a new endobronchial drug delivery catheter. Background and objective: Intratumoral administration of chemotherapeutic agents is a treatment modality that has proven efficacious in reducing the recurrence of tumours and increases specificity […]
Journal of Controlled Release: Defining drug and target protein distributions after stent-based drug release: Durable versus deployable coatings
Tzafriri AR, Garcia-Polite F, Li X, Keating J, Balaguer JM, Zani B, Bailey L, Markham P, Kiorpes TC, Carlyle W, Edelman ER. Defining drug and target protein distributions after stent-based drug release: Durable versus deployable coatings. Summary: Innovations in drug eluting stent designs make it increasingly important to develop models for differentiating performance through spatial […]