Tzafriri AR. “Enhanced Plaque Modification of Cadaveric Human Calcified Peripheral Arteries Treated with a Dynamic Scoring Catheter“ Summary: Calcific atherosclerosis is a major challenge to intraluminal drug delivery treatments in peripheral artery disease. We evaluated the effects of dynamic scoring on the surface morphology of calcified peripheral arteries. Diagnostic imaging of 2 fresh human cadaveric […]
Tag Archives: 2018
International Journal of Toxicology: Percutaneous Hepatic Perfusion With Filtered Melphalan for Localized Treatment of Metastatic Hepatic Disease: A Risk Assessment
Pauline E McEwan, Lynn Bailey, David Trost, Christopher Scull, John H Keating, Misty Williams, Robert J Guttendorf. Percutaneous Hepatic Perfusion With Filtered Melphalan for Localized Treatment of Metastatic Hepatic Disease: A Risk Assessment. Summary: Regional therapies for metastatic liver disease have garnered interest in recent years due to technological advances in drug delivery. A percutaneous […]
Press Release: CBSET partner CILcare leads Phase 2 of $2.1 million total DETECT project to develop a preclinical model for tinnitus drug therapy development
LEXINGTON, Mass., and MONTPELLIER, France, Nov. 12, 2018 — CBSET partner CILcare, a world-leading CRO (clinical research organization) specialized in the research and development of drugs and medical devices in the field of hearing, has initiated the second phase of its ongoing tinnitus research project, DETECT, a public/private project being conducted in collaboration with the […]
Press Release: Preclinical safety studies demonstrate that drug presence can accentuate pathological responses at stent fracture sites
“These findings could potentially have a seminal effect on development of innovative DES coating designs to treat coronary artery disease,” said Rami Tzafriri, Ph.D., Director of Research and Innovation, CBSET. “Animal models of real-world scenarios such as stent fracture offer an exciting opportunity to differentiate the relative effectiveness of novel drug eluting stent designs that […]
Biomaterials Forum: Stem cell therapies for peripheral arterial disease: clinical status, promising biomaterials strategies and tips for successful translation
Ngan F. Huang, Michael Naimark, Rami Tzafriri. “Stem cell therapies for peripheral arterial disease: clinical status, promising biomaterials strategies and tips for successful translation” Summary: Cell transplantation into the ischemic tissue is being studied as a therapeutic strategy to re-establish functional collateral networks that supply oxygenated blood and preserve tissue viability. While the clinical picture is evolving, […]
Biointerface: Immunofluorescence and Computational Methods for Tracking Tissue Distribution of Drugs in Support of Stent Coating Innovations
Tzafriri AR. “Immunofluorescence and Computational Methods for Tracking Tissue Distribution of Drugs in Support of Stent Coating Innovations” Summary: Drug eluting stents (DES) have revolutionized the treatment of atherosclerosis in coronary vasculature. The key has been to identify biological agents that can counter hyperplastic tissue responses to stent expansion/implantation and to develop effective and safe […]
Cardiovascular Revascularization Medicine: Anatomical and procedural determinants of ambulatory blood pressure lowering following catheter-based renal denervation using radiofrequency
Lauder L, Ewen S, Tzafriri AR, Edelman ER, Cremers B, Kulenthiran S, Ukena C, Linz D, Kindermann I, Tsioufis C, Scheller B, Böhm M, Mahfoud F. Anatomical and procedural determinants of ambulatory blood pressure lowering following catheter-based renal denervation using radiofrequency. Summary: Because little is known of the impact of renal anatomy and procedural parameters […]
TCT 2018: Tracking tissue distribution and retention of Sirolimus and analog delivered from polymer free drug coated stents
Abraham Rami Tzafriri, Lucas Rotllant Daurella, John Keating, Fernando Garcia Polite, Xiaojian Li, Lynn Bailey, Peter Markham, Debashis Dutta, Hans-Peter Stoll, Elazer R. Edelman. “Tracking tissue distribution and retention of Sirolimus and analog delivered from polymer free drug coated stents” Summary: Biolimus A9 is a highly lipophilic Sirolimus analog (13-fold the lipophilicity of the parent drug) […]
TCT 2018: Superior and proximal nerves in porcine renal arteries are least accessible to radiofrequency ablation due to shielding by peri-arterial blood vessels and lymph nodes
Abraham R. Tzafriri, PhD, Fernando Garcia-Polite, PhD, John H. Keating DVM, DACVP, Anna-Maria Spognardi, BS, Peter Markham, MS, Elazer Edelman, MD, PhD. “Superior and proximal nerves in porcine renal arteries are least accessible to radiofrequency ablation due to shielding by peri-arterial blood vessels and lymph nodes.” Summary: Periarterial lymph nodes and blood vessels can shield nerves […]
TCT 2018: Splenic Artery Denervation: Rationale, Feasibility, and Early Pre-Clinical Experience in a Porcine Model of Inflammatory Arthritis
Mazen Albaghdadi, MD MS, Fernando Garcia-Polite, PhD, Brett Zani, PhD, John Keating DVM, DACVP, Raffaele Melidone, DVM, DACVP, Anna Spognardi, BS, Peter Markham, MS, Abraham Tzafriri, PhD. “Splenic Artery Denervation: Rationale, Feasibility, and Early Pre-Clinical Experience in a Porcine Model of Inflammatory Arthritis.” Summary: The spleen plays an important role in the immune response to inflammatory conditions […]