Zani BG, Kojima K, Vacanti CA, and Edelman ER. Tissue engineered endothelial and epithelial implants differentially and synergistically regulate airway repair. Summary: The trilaminate vascular architecture provides biochemical regulation and mechanical integrity. Yet regulatory control can be regained after injury without recapitulating tertiary structure. Tissue-engineered (TE) endothelium controls repair even when placed in the perivascular space […]
Tag Archives: 2010 and earlier
Journal of Controlled Release: Intravascular drug release kinetics dictate arterial drug deposition, retention, and distribution
Balakrishnan B, Dooley J, Kopia G, Edelman ER. Intravascular drug release kinetics dictate arterial drug deposition, retention, and distribution. Summary: Millions of patients worldwide have received drug-eluting stents to reduce their risk for in-stent restenosis. The efficacy and toxicity of these local therapeutics depend upon arterial drug deposition, distribution, and retention. To examine how administered dose […]
Biochem J: Endosomal receptor kinetics determine the stability of intracellular growth factor signalling complexes
Tzafriri, A.R. and E.R. Edelman. Endosomal receptor kinetics determine the stability of intracellular growth factor signalling complexes. Summary: There is an emerging paradigm that growth factor signalling continues in the endosome and that cell response to a growth factor is defined by the integration of cell surface and endosomal events. As activated receptors in the endosome […]
TCT 2006 : Dissociating DES safety & efficacy: Endothelial regrowth & drug effect after abluminal or circumferential paclitaxel delivery from bioerodable polymer in porcine coronaries
Spognardi AM. ‘Dissociating DES safety & efficacy: Endothelial regrowth & drug effect after abluminal or circumferential paclitaxel delivery from bioerodable polymer in porcine coronaries.’ Transcatheter Cardiovascular Therapeutics, Washington, DC, 2006.
TCT 2006 : Self-expanding Coronary Stents Entirely Incorporated within an 0.014” Wire: Late Lumen Gain 90 days after Porcine Coronary Artery Implantation
Spognardi AM. ‘Self-expanding Coronary Stents Entirely Incorporated within an 0.014” Wire: Late Lumen Gain 90 days after Porcine Coronary Artery Implantation.’ Transcatheter Cardiovascular Therapeutics, Washington, DC, 2006.
Circulation: Differential Response to Vascular Stenting in Control Vs Insulin-Treated Diabetic Pigs: Analysis of Carotid, Renal and Coronary Bare Metal Stents (BMS) and Coronary Sirolimus Eluting Stents (SES)
Jonas M, Edelman ER, Baker AB, Spognardi AM, Groothuis A, Seifert P, Rogers C. Differential Response to Vascular Stenting in Control Vs Insulin-Treated Diabetic Pigs: Analysis of Carotid, Renal and Coronary Bare Metal Stents (BMS) and Coronary Sirolimus Eluting Stents (SES). Circulation 2006; 114:II_392.
TCT 2005: Total Paclitaxel Dose Optimization With Minimized Abluminal Bioerodable Polymer Stent Coatings Provides Safe Delivery of Paclitaxel in Porcine Coronary Arteries
Spognardi AM. ‘Total Paclitaxel Dose Optimization With Minimized Abluminal Bioerodable Polymer Stent Coatings Provides Safe Delivery of Paclitaxel in Porcine Coronary Arteries.’ Transcatheter Cardiovascular Therapeutics, Washington, DC, 2005.
Circ Res: Vascular neointimal formation and signaling pathway activation in response to stent injury in insulin-resistant and diabetic animals
M Jonas M, Edelman ER, Groothuis A, Baker AB, Seifert P, Rogers C. Vascular neointimal formation and signaling pathway activation in response to stent injury in insulin-resistant and diabetic animals. Summary: Diabetes and insulin resistance are associated with increased disease risk and poor outcomes from cardiovascular interventions. Even drug-eluting stents exhibit reduced efficacy in patients […]
Journal of Controlled Release: Local and systematic drug competition in drug-eluting stent tissue deposition properties
Levin AD, Jonas M, Hwang CW, Edelman ER. Local and systematic drug competition in drug-eluting stent tissue deposition properties. Summary: The efficacy of drug-eluting stents (DES) requires delivery of potent compounds directly to the underlying arterial tissue. The commercially available DES drugs rapamycin and paclitaxel bind specifically to their respective therapeutic targets, FKBP12 and polymerized microtubules, […]
Circulation: Strut position, blood flow, and drug deposition: implications for single and overlapping drug-eluting stents
Balakrishnan B, Tzafriri AR, Seifert P, Groothuis A, Rogers C, Edelman ER. Strut position, blood flow, and drug deposition: implications for single and overlapping drug-eluting stents. Summary: The intricacies of stent design, local pharmacology, tissue biology, and rheology preclude an intuitive understanding of drug distribution and deposition from drug-eluting stents (DES). Circulation 2005 Jun 7;111(22):2958-65.