Levin AD, Jonas M, Hwang CW, Edelman ER. Local and systematic drug competition in drug-eluting stent tissue deposition properties.
Summary: The efficacy of drug-eluting stents (DES) requires delivery of potent compounds directly to the underlying arterial tissue. The commercially available DES drugs rapamycin and paclitaxel bind specifically to their respective therapeutic targets, FKBP12 and polymerized microtubules, while also associating in a more general manner with other tissue elements.