Influence of DCB Design and Procedural Parameters on Drug Delivery, presented by Abraham Rami Tzafriri PhD, CBSET Director of Research and Innovation.

Drug-coated balloon (DCB) design has implications for both local drug delivery and off-target drug delivery.

For local drug delivery, unlike DEB, coating transfer to tissue is driven by mechanical surface interactions. In addition, local-contact pressure-driven delivery is dictated by balloon design, coating morphology and lumen geometry.

For off-target delivery, unlike DEB, coating transfer to tissue is driven by frictional surface interactions. Friction-driven delivery is dictated by tracking interactions at vascular bends and DCB fold rotation in stenosed lesions.