EuroPCR: Visualizing the tissue distribution and retention of Sirolimus and analog delivered from polymer free drug coated stents

Tzafriri AR, Rotllant Daurella L,Keating JH, Garcia Polite F, Li X, Bailey L, Markham PM, Dutta D, Stoll HP, Edelman ER. “Visualizing the tissue distribution and retention of Sirolimus and analog delivered from polymer free drug coated stents”

Summary: Biolimus A9 is a highly lipophilic Sirolimus analog (13-fold the lipophilicity of the parent drug) specifically designed for local-drug delivery. We developed immunofluorescence (IF) methods to contrast the arterial distribution of Sirolimus and Biolimus A9 after implantation of polymer-free drug-coated stents (PF DCS) in the pig coronary artery model.

Euro18A-OP173 Oral Presentation. Presented at EuroPCR, 2018 May 21-24; Paris France.