EuroPCR: Local, regional, and systemic factors in BRS thrombosis in small vessels: understanding the sub-2.5mm barrier

Kumaran Kolandaivelu, Josep Maria Balaguer, Maria Tomas Gracia, Jose Manuel Sanes, Enric Estruch, Laura Perkins, Syed Hossainy, Rami Tzafriri, Peter Markham, Elazer Edelman. “Local, regional, and systemic factors in BRS thrombosis in small vessels: understanding the sub-2.5mm barrier.“

Summary: Device thrombosis dominates bioresorbable vascular scaffolds (BVS) safety concerns, particularly in sub-2.5mm vessels. To better understand the mechanistic basis of this size threshold, we evaluated scaffold thrombogenicity (ST) in clinical- (thick; 157µm) and production-grade (thin; 99-119µm) BVS in computational and bench-top thrombosis models where vessel diameter and study conditions could be tuned precisely.

Presented at EuroPCR, 2018 May 21-24; Paris France.