Tzafriri, A.R., M. Bercovier, and H. Parnas. Reaction diffusion model of the enzymatic erosion of insoluble fibrillar matrices.
Summary: Predicting the time course of in vivo biodegradation is a key issue in the design of an increasing number of biomedical applications such as sutures, tissue analogs and drug-delivery devices. The design of such biodegradable devices is hampered by the absence of quantitative models for the enzymatic erosion of solid protein matrices. In this work, we derive and simulate a reaction diffusion model for the enzymatic erosion offibrillar gels that successfully reproduces the main qualitative features of this process.