Baker A, Chatzizisis Y, Beigel R, Jonas M, Stone B, Coskun A, Maynard C, Rogers C, Koskinas K, Feldman C, Stone P, Edelman ER. Regulation of heparanase expression in coronary artery disease in diabetic hyperlipidemic swine.

Summary: Enzymatic degradation of the extracellular matrix is known to be powerful regulator of atherosclerosis. However, little is known about the enzymatic regulation of heparan sulfate proteoglycans (HSPGs) during the formation and progression of atherosclerotic plaques.

Atherosclerosis 2010 Dec; 213(2):436-442.